Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

The Other Angiotensin II Receptor: AT2R as a Therapeutic Target

(2020) Lucienne Juillerat-Jeanneret   JOURNAL OF MEDICINAL CHEMISTRY

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

(2020) Laura M. Wingler et al.   SCIENCE

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

(2019) Laura M. Wingler et al.   CELL

A Series of Analogues to the AT2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

(2019) Rebecka Isaksson et al.   ChemistryOpen

QresFEP: An Automated Protocol for Free Energy Calculations of Protein Mutations in Q

(2019) Willem Jespers et al.   Journal of Chemical Theory and Computation

The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone

(2019) Hidetsugu Asada et al.   STRUCTURE

From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidemimetics

(2018) Mathias Hallberg et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog

(2018) Hidetsugu Asada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog

(2018) Hidetsugu Asada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury

(2018) Anandharajan Rathinasabapathy et al.   Frontiers in Physiology

Small-molecule AT2 receptor agonists

(2017) Mathias Hallberg et al.   MEDICINAL RESEARCH REVIEWS

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

(2017) Willem Jespers et al.   MOLECULES

Structural determinants of subtype selectivity and functional activity of angiotensin II receptors

(2016) Jessica Sallander et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Update on angiotensin AT2 receptors

(2016) Robert M. Carey   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

(2015) Haitao Zhang et al.   CELL

Free energy calculations of A2A adenosine receptor mutation effects on agonist binding

(2015) Henrik Keränen et al.   CHEMICAL COMMUNICATIONS

Angiotensin type 2 receptors: blood pressure regulation and end organ damage

(2015) Colin Sumners et al.   CURRENT OPINION IN PHARMACOLOGY

Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders

(2015) Ludovit Paulis et al.   DRUGS

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

(2015) Haitao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Peptide and Protein Torsional Energetics with the OPLS-AA Force Field

(2015) Michael J. Robertson et al.   Journal of Chemical Theory and Computation

Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors

(2014) Mathias Hallberg   MEDICINAL RESEARCH REVIEWS

Structural and Energetic Effects of A2A Adenosine Receptor Mutations on Agonist and Antagonist Binding

(2014) Henrik Keränen et al.   PLoS One

Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands

(2014) Charlotta Wallinder et al.   ACS Medicinal Chemistry Letters

Saralasin and Sarile Are AT2 Receptor Agonists

(2014) Marie-Odile Guimond et al.   ACS Medicinal Chemistry Letters

Computational Prediction of Alanine Scanning and Ligand Binding Energetics in G-Protein Coupled Receptors

(2014) Lars Boukharta et al.   PLoS Computational Biology

N-Aryl Isoleucine Derivatives as Angiotensin II AT2Receptor Ligands

(2014) Malte Behrends et al.   ChemistryOpen

Characterization of the dynamic events of GPCRs by automated computational simulations

(2013) Hugo Gutiérrez-de-Terán et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Intrarenal Angiotensin III Is the Predominant Agonist for Proximal Tubule Angiotensin Type 2 Receptors

(2012) Brandon A. Kemp et al.   HYPERTENSION

Key advances in antihypertensive treatment

(2012) Ludovit Paulis et al.   Nature Reviews Cardiology

Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers

(2012) Hanna Andersson et al.   International Journal of Hypertension

Targeting the insulin-regulated aminopeptidase/AT4 receptor for cognitive disorders

(2009) M. Halberg   DRUG NEWS & PERSPECTIVES

The past, present and future of angiotensin II type 2 receptor stimulation

(2009) U. Muscha Steckelings et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Cardiac c-kit+AT2+ Cell Population is Increased in Response to Ischemic Injury and Supports Cardiomyocyte Performance

(2009) Wassim Altarche-Xifró et al.   STEM CELLS

Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships

(2008) Charlotta Wallinder et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small peptides mimicking substance P (1–7) and encompassing a C-terminal amide functionality

(2008) Rebecca Fransson et al.   NEUROPEPTIDES

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT 2 Receptor–Mediated Natriuresis In Rats

(2007) Shetal H. Padia et al.   HYPERTENSION