标题
Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target
作者
关键词
-
出版物
Pharmaceutics
Volume 12, Issue 5, Pages 416
出版商
MDPI AG
发表日期
2020-05-05
DOI
10.3390/pharmaceutics12050416
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening
- (2020) Ting Li et al. BIOORGANIC CHEMISTRY
- The amyloid precursor protein affects glyceraldehyde 3-phosphate dehydrogenase levels, organelle localisation and thermal stability
- (2020) Alexandré Delport et al. MOLECULAR BIOLOGY REPORTS
- Aberrant expression of sperm‑specific glycolytic enzymes are associated with poor sperm quality
- (2019) Xuexia Liu et al. Molecular Medicine Reports
- Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase
- (2019) Pavel Semenyuk et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis
- (2019) Yong Q. Li et al. CELLULAR SIGNALLING
- Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer
- (2019) Ming-Chuan Hsu et al. Journal of Hematology & Oncology
- E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells
- (2019) Xiangzhu Tian et al. Molecular Medicine Reports
- The enhancement of glycolysis regulates pancreatic cancer metastasis
- (2019) Jinshou Yang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis
- (2019) Maria V. Liberti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The formation of hybrid complexes between isoenzymes of glyceraldehyde‐3‐phosphate dehydrogenase regulates its aggregation state, the glycolytic activity and sphingolipid status inSaccharomyces cerevisiae
- (2019) Francisca Randez‐Gil et al. Microbial Biotechnology
- Binding of alpha-synuclein to partially oxidized glyceraldehyde-3-phosphate dehydrogenase induces subsequent inactivation of the enzyme
- (2018) Kseniya Barinova et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- GAPDH-targeted therapy – A new approach for secondary damage after traumatic brain injury on rats
- (2018) Vladimir F. Lazarev et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death
- (2018) Roshan Kumar et al. BIOMACROMOLECULES
- Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate dehydrogenase
- (2018) Vladimir I. Muronetz et al. CURRENT MEDICINAL CHEMISTRY
- Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells
- (2018) Elizabeth A. Sweeny et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evaluation of common housekeeping proteins under ischemic conditions and/or rt-PA treatment in bEnd.3 cells
- (2018) Pau Comajoan et al. Journal of Proteomics
- Disruption of the GluA2/GAPDH complex using TAT-GluA2NT1-3-2 peptide protects against AMPAR-mediated excitotoxicity after epilepsy
- (2018) Jinghui Zhang et al. NEUROREPORT
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
- (2018) Michael D. Kornberg et al. SCIENCE
- Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β
- (2018) Tanusree Sen et al. Science Signaling
- Metabolic changes in bladder cancer
- (2018) Benjamin L. Woolbright et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β
- (2018) Tanusree Sen et al. Science Signaling
- Cytosolic GAPDH as a redox-dependent regulator of energy metabolism
- (2018) Markus Schneider et al. BMC PLANT BIOLOGY
- Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases
- (2018) Michael A. Sirover CANCER AND METASTASIS REVIEWS
- GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis
- (2018) Jia-Shu Yang et al. NATURE
- CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer
- (2018) Xing-Yu Zhong et al. Cell Reports
- Identification of key genes and pathways using bioinformatics analysis in septic shock children
- (2018) Junting Yang et al. Infection and Drug Resistance
- Glyceraldehyde-3-phosphate dehydrogenase: Aggregation mechanisms and impact on amyloid neurodegenerative diseases
- (2017) Vladimir I. Muronetz et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death
- (2017) Hidemitsu Nakajima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a
- (2016) M. Fang et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Anti-GAPDHS antibodies: a biomarker of immune infertility
- (2016) Jun Fu et al. CELL AND TISSUE RESEARCH
- GAPDH binds Akt to facilitate cargo transport in the early secretory pathway
- (2016) Ellen J. Tisdale et al. EXPERIMENTAL CELL RESEARCH
- Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress
- (2016) Vladimir F. Lazarev et al. FREE RADICAL BIOLOGY AND MEDICINE
- Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression
- (2016) Kaiyan Liu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- GAPDH Binding to TNF-α mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism
- (2016) Patrick Millet et al. JOURNAL OF IMMUNOLOGY
- Glyceraldehyde 3-phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease
- (2016) Elena R. Mikhaylova et al. JOURNAL OF NEUROCHEMISTRY
- Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade
- (2016) Prasun Guha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidation of glyceraldehyde-3-phosphate dehydrogenase decreases sperm motility in diabetes mellitus
- (2015) Jie Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor peptide: A potential therapeutic strategy against oxidative stress-induced cell death
- (2015) Masanori Itakura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Standard loading controls are not reliable for Western blot quantification across brain development or in pathological conditions
- (2015) Kate Goasdoue et al. ELECTROPHORESIS
- Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease
- (2015) S. Hwang et al. EMBO Molecular Medicine
- GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay
- (2015) Vladimir F. Lazarev et al. FEBS LETTERS
- Novel insights in mammalian catalase heme maturation: Effect of NO and thioredoxin-1
- (2015) Ritu Chakravarti et al. FREE RADICAL BIOLOGY AND MEDICINE
- High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1
- (2015) Sandra Suarez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease
- (2015) Masanori Itakura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
- (2015) Chunmei Chang et al. MOLECULAR CELL
- Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas
- (2015) Lihong Hao et al. PROTEOMICS
- GAPDH-knockdown reduce rotenone-induced H9C2 cells death via autophagy and anti-oxidative stress pathway
- (2015) Shao Liang et al. TOXICOLOGY LETTERS
- Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway
- (2015) Anoop S. Chauhan et al. Scientific Reports
- Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma
- (2015) Shanmugasundaram Ganapathy-Kanniappan et al. Oncotarget
- Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation
- (2014) Da-Woon Jung et al. CHEMISTRY & BIOLOGY
- Effect of Resveratrol and Tiron on the Inactivation of Glyceraldehyde-3- phosphate Dehydrogenase Induced by Superoxide Anion Radical
- (2014) A. Rodacka et al. CURRENT MEDICINAL CHEMISTRY
- Evidence for thiol/disulfide exchange reactions between tubulin and glyceraldehyde-3-phosphate dehydrogenase
- (2014) Lisa M. Landino et al. Cytoskeleton
- Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase
- (2014) Andre L. Samson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Proteomic Approach for the Involvement of the GAPDH in Alzheimer Disease in the Blood of Moroccan FAD Cases
- (2014) Nadia El Kadmiri et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin’s B lymphomas via NF-κB-dependent induction of HIF-1α
- (2014) J Chiche et al. LEUKEMIA
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice
- (2014) Yuki Takaoka et al. Scientific Reports
- Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage
- (2014) Dongxu Zhai et al. Molecular Brain
- Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
- (2014) Alexander A Shestov et al. eLife
- GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death
- (2013) M A Jacquin et al. CELL DEATH AND DIFFERENTIATION
- Sulfur mustard induced nuclear translocation of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH)
- (2013) Dirk Steinritz et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by Protein Kinase Cδ (PKCδ) Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury
- (2013) Gouri Yogalingam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Rice NAD+-Dependent Histone Deacetylase OsSRT1 Targets Preferentially to Stress- and Metabolism-Related Genes and Transposable Elements
- (2013) Xiaochao Zhong et al. PLoS One
- Heme Binding Properties of Glyceraldehyde-3-phosphate Dehydrogenase
- (2012) Luciana Hannibal et al. BIOCHEMISTRY
- Thioredoxin-1 Regulates Cellular Heme Insertion by ControllingS-Nitrosation of Glyceraldehyde-3-phosphate Dehydrogenase
- (2012) Ritu Chakravarti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component
- (2012) C. Nicholls et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells
- (2011) Yasuki Higashimura et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells
- (2011) Manali Phadke et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease
- (2011) I. V. Guzhova et al. HUMAN MOLECULAR GENETICS
- Akt2 Kinase Suppresses Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH)-mediated Apoptosis in Ovarian Cancer Cells via Phosphorylating GAPDH at Threonine 237 and Decreasing Its Nuclear Translocation
- (2011) Qiaojia Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil
- (2011) María Sánchez-Aragó et al. Journal of Translational Medicine
- Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation
- (2010) Mireia Ventura et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- GAPDH regulates cellular heme insertion into inducible nitric oxide synthase
- (2010) R. Chakravarti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Involvement of glyceraldehyde-3-phosphate dehydrogenase in rotenone-induced cell apoptosis: Relevance to protein misfolding and aggregation
- (2009) Jinsha Huang et al. BRAIN RESEARCH
- siah-1 Protein Is Necessary for High Glucose-induced Glyceraldehyde-3-phosphate Dehydrogenase Nuclear Accumulation and Cell Death in Müller Cells
- (2009) E. Chepchumba K. Yego et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death
- (2009) Hidemitsu Nakajima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Binding of Glyceraldehyde 3-Phosphate Dehydrogenase to Telomeric DNA Protects Telomeres against Chemotherapy-Induced Rapid Degradation
- (2009) Neil A. Demarse et al. JOURNAL OF MOLECULAR BIOLOGY
- The Glyceraldehyde-3-Phosphate Dehydrogenase and the Small GTPase Rab 2 Are Crucial for Brucella Replication
- (2009) Emilie Fugier et al. PLoS Pathogens
- Non-native glyceraldehyde-3-phosphate dehydrogenase can be an intrinsic component of amyloid structures
- (2008) Irina Naletova et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- O-GlcNAcylation disrupts glyceraldehyde-3-phosphate dehydrogenase homo-tetramer formation and mediates its nuclear translocation
- (2008) Jungeun Park et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy
- (2008) M. Kanwar et al. DIABETES
- Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice
- (2008) Yong Wang et al. FERTILITY AND STERILITY
- GAPDH Is Conformationally and Functionally Altered in Association with Oxidative Stress in Mouse Models of Amyotrophic Lateral Sclerosis
- (2008) Anson Pierce et al. JOURNAL OF MOLECULAR BIOLOGY
- Characterization of the interaction between Aβ 1–42 and glyceraldehyde phosphodehydrogenase
- (2008) Yann Verdier et al. JOURNAL OF PEPTIDE SCIENCE
- PARP-1 Inhibits Glycolysis in Ischemic Kidneys
- (2008) K. Devalaraja-Narashimha et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis
- (2008) Nilkantha Sen et al. NATURE CELL BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started