Looking at New Unexpected Disease Targets in LMNA-Linked Lipodystrophies in the Light of Complex Cardiovascular Phenotypes: Implications for Clinical Practice

Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

(2020) Agian Jeffilano Barinda et al.   Nature Communications

Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies

(2019) Karim Wahbi et al.   CIRCULATION

The structural and gene expression hypotheses in laminopathic diseases—not so different after all

(2019) Selma Osmanagic-Myers et al.   MOLECULAR BIOLOGY OF THE CELL

Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome

(2018) Magda R. Hamczyk et al.   Annual Review of Physiology

The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks

(2018) Nolwenn Briand et al.   HUMAN MOLECULAR GENETICS

Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome

(2018) Leslie B. Gordon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives

(2018) Corinne Vigouroux et al.   Nucleus

Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives

(2018) Corinne Vigouroux et al.   Nucleus

Clinical Manifestations and Long-Term Mortality in Lamin A/C Mutation Carriers From a Japanese Multicenter Registry

(2018) Kenzaburo Nakajima et al.   CIRCULATION JOURNAL

Emerging Roles of Vascular Endothelium in Metabolic Homeostasis

(2018) Xinchun Pi et al.   CIRCULATION RESEARCH

Cardiometabolic assessment of lamin A/C gene mutation carriers: A phenotype–genotype correlation

(2018) M. Kwapich et al.   DIABETES & METABOLISM

Lamin and the heart

(2017) Gabriella Captur et al.   HEART

A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus

(2017) Anja Oldenburg et al.   JOURNAL OF CELL BIOLOGY

A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation

(2017) Iram Hussain et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes

(2017) Ana Rita G. Francisco et al.   Revista Portuguesa de Cardiologia

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

(2016) Pauline Afonso et al.   ATHEROSCLEROSIS

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

(2016) Maria Chatzifrangkeskou et al.   HUMAN MOLECULAR GENETICS

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline

(2016) Rebecca J. Brown et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy

(2016) Caroline Le Dour et al.   JOURNAL OF LIPID RESEARCH

Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers

(2016) Saurabh Kumar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

(2016) José Rivera-Torres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminopathies disrupt epigenomic developmental programs and cell fate

(2016) Jelena Perovanovic et al.   Science Translational Medicine

Metabolic and cardiac phenotype characterization in 37 atypical Dunnigan patients with nonfarnesylated mutated prelamin A

(2015) Philippe Andre et al.   AMERICAN HEART JOURNAL

Evaluation of epicardial adipose tissue in familial partial lipodystrophy

(2015) Amélio Fernando Godoy-Matos et al.   Diabetology & Metabolic Syndrome

Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment

(2014) Nathalie Bonello-Palot et al.   ATHEROSCLEROSIS

Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging

(2013) Michael D. Nelson et al.   AMERICAN JOURNAL OF CARDIOLOGY

Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

(2013) Guillaume Bidault et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An inheritedLMNAgene mutation in atypical Progeria syndrome

(2012) Yassamine Doubaj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

(2011) Véronique Béréziat et al.   AMERICAN JOURNAL OF PATHOLOGY

Prelamin A-mediated nuclear envelope dynamics in normal and laminopathic cells: Figure 1

(2011) Giovanna Lattanzi   BIOCHEMICAL SOCIETY TRANSACTIONS

LMNA cardiomyopathy: cell biology and genetics meet clinical medicine

(2011) J. T. Lu et al.   Disease Models & Mechanisms

A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into the Pathogenicity of Nonfarnesylated Prelamin-A

(2011) Caroline Le Dour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy

(2010) Beatrice C. Lupsa et al.   MEDICINE

Overlapping syndrome with familial partial lipodystrophy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous missense lamin A/C mutations

(2009) L Subramanyam et al.   CLINICAL GENETICS

The R439C mutation inLMNAcauses lamin oligomerization and susceptibility to oxidative stress

(2009) Valerie L.R.M. Verstraeten et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Atypical Progeroid Syndrome due to Heterozygous MissenseLMNAMutations

(2009) Abhimanyu Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement

(2009) Nicola Carboni et al.   MUSCLE & NERVE

A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy

(2008) David Araújo-Vilar et al.   CLINICAL ENDOCRINOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

(2008) B. C. Capell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA