Article
Medicine, Research & Experimental
Ying Zhang, Xiangyang Cao, Peifeng Li, Yanan Fan, Leilei Zhang, Xianghao Ma, Ruibo Sun, Youwen Liu, Wuyin Li
Summary: The study demonstrates that BMSC-exo carrying miR-935 promotes osteoblast proliferation and differentiation through targeting STAT1.
Article
Biotechnology & Applied Microbiology
Min Qiu, Shuheng Zhai, Qin Fu, Da Liu
Summary: The research reveals that exosomal miR-150-3p promotes osteoblast proliferation and differentiation in osteoporosis, providing a new insight for treating patients with osteoporosis.
HUMAN GENE THERAPY
(2021)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Cell & Tissue Engineering
Ling Ma, Xiaowei Wei, Wei Ma, Yusi Liu, Yanfu Wang, Yiwen He, Shanshan Jia, Yu Wang, Wenting Luo, Dan Liu, Tianchu Huang, Jiayu Yan, Hui Gu, Yuzuo Bai, Zhengwei Yuan
Summary: This study aimed to assess the effect of neural stem cell (NSC)-derived exosomes on bone marrow mesenchymal stem cell (BMSC) neuronal differentiation and observe the therapeutic effect in an ex vivo rat spinal bifida aperta (SBA) embryo model. The results showed that NSC-derived exosomes increased the neuronal differentiation rate of BMSCs and were enriched in Netrin1, which positively regulated neuronal differentiation. Furthermore, the Netrin1-induced NSC neuronal differentiation was mediated by the Hand2/Phox2b axis. Therefore, NSC-derived exosomes are critical inducers of BMSC neuronal differentiation and have potential as a treatment agent for SBA.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Jingcui Peng, Sa Li, Bin Li, Wenxia Hu, Cuimin Ding
Summary: This study found that miR-486-5p inhibits lung cancer progression by regulating the expression of MIER3, and this effect is mediated by exosomes carried by mesenchymal stem cells.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin, Lei Zhang
Summary: Stem cell senescence causes functional declines and disrupts bone environment homeostasis. Stem cell-derived exosomes are a promising therapy for aging-related osseous diseases. This study demonstrates the potential of osteoinductive exosomes in bone repair for aging individuals and highlights the importance of considering endocytic mechanisms and avoiding negative effects in future therapeutic design for aging populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Critical Care Medicine
Meng Deng, Jing He, Changfu Hao, Yonghua Guo, Huifang Si, Xuedan Deng, Chengpeng Zhang, Shiyu Li, Sanqiao Yao, Wenjie Ren, Wu Yao
Summary: This study investigates the effect of bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs (BMSCs-Exo) on blast lung injuries (BLIs) caused by gas explosion in rats. The findings demonstrate that BMSCs and BMSCs-Exo significantly reduce oxidative stress and inflammatory infiltration in the lungs. Additionally, they regulate apoptosis, autophagy, and pyroptosis, suggesting their potential in attenuating BLI.
Article
Cell Biology
Chong Huang, Lu Zhao, Yun Xiao, Zihao Tang, Li Jing, Kai Guo, Lei Tian, Chunlin Zong
Summary: This study aimed to investigate the role of macrophages and macrophage-derived exosomes in restoring irradiated bone marrow mesenchymal stem cells (BMMSCs) function. M2 macrophage-derived exosomes (M2D-exos) were found to inhibit the fibrogenic differentiation and promote the osteogenic differentiation of irradiated BMMSCs. The miRNA miR-142-3p in M2D-exos targeted transforming growth factor beta 1 (TGF-beta 1) to restore the differentiation balance of irradiated BMMSCs. These findings provide a promising and cell-free method to treat irradiation-induced bone damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
H. Yu, J. Zhang, X. Liu, Y. Li
Summary: BMSC-derived exosomes carrying miR-136-5p inhibit LRP4 and activate the Wnt/beta-catenin pathway, promoting fracture healing by enhancing osteoblast proliferation and differentiation.
BONE & JOINT RESEARCH
(2021)
Article
Environmental Sciences
Hongping Gu, Jinrong Li, Yuehan Ni
Summary: This study investigates the therapeutic effect of sinomenine on renal fibrosis and its mechanism. The results show that sinomenine can improve the progression of renal fibrosis by regulating the expression of miR-204-5p in exosomes from bone marrow mesenchymal stem cells and the PI3K-AKT pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Cell Biology
Huan Zhou, Lei Zhang, Yue Chen, Chun-Hui Zhu, Fa-Ming Chen, Ang Li
Summary: Bone formation is a complex regeneration process regulated by multiple signaling pathways, with the Hedgehog (Hh) pathway playing a crucial role. Dysregulation of the Hh pathway in adults is associated with bone-related diseases, while during repair processes, it can be reactivated to modulate bone formation. Current therapeutic strategies targeting the Hh cascade for osteogenesis coordination have been reviewed.
CELL PROLIFERATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fen Liu, Wen Sui, Zhi-Fei Zhou, Yang Mi, Tong-Qiang He, Zhi-Bin Li, Yong-Long Hong, Fa-Ming Chen
Summary: This study found an association between periodontitis and gestational diabetes mellitus (GDM), with treatment reducing the incidence of GDM. The presence of Porphyromonas gingivalis was associated with high levels of inflammatory mediators, highlighting a potential role in the development of GDM.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Engineering, Biomedical
Yuan Yin, Bei-Min Tian, Xuan Li, Yao-Cheng Yu, Dao-Kun Deng, Li-Juan Sun, Hong-Lei Qu, Rui-Xin Wu, Xin-Yue Xu, Hai-Hua Sun, Ying An, Xiao-Tao He, Fa-Ming Chen
Summary: This study investigates the compromised osteogenic potential of periodontal ligament stem cells (PDLSCs) under inflammatory conditions and explores the underlying mechanism. The researchers found that the disruption of PDLSC autophagy under inflammatory conditions was associated with dysfunction of the cellular autophagy-lysosome system. Furthermore, they demonstrated that treatment with gold nanoparticles (Au NP) could rescue the osteogenic potential of inflamed PDLSCs by restoring the compromised autophagy-lysosome system. This study highlights the importance of the autophagy-lysosome system in cellular osteogenesis under inflammatory conditions and suggests the potential use of nanomaterials for rescuing inflammation-induced cell dysfunction and aiding tissue regeneration.
Article
Dentistry, Oral Surgery & Medicine
Jun Bao, Lili Li, Yangheng Zhang, Min Wang, Faming Chen, Shaohua Ge, Bin Chen, Fuhua Yan
Summary: This study aimed to investigate whether periodontitis induces dysbiosis of gut microbiota through invasion by salivary microbes. The results showed significant differences in both the faecal and salivary microbiota between periodontally healthy participants and patients with severe periodontitis. Furthermore, transplantation of salivary microbes into mice revealed significant differences in the composition of the gut microbiota and alterations in intestinal health-related markers. In addition, salivary microbes were found to persist in the gut for at least 24 hours.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Cell & Tissue Engineering
Yi-Lin Zhang, Fen Liu, Zhi-Bang Li, Xiao-Tao He, Xuan Li, Rui-Xin Wu, Hai-Hua Sun, Shao-Hua Ge, Fa-Ming Chen, Ying An
Summary: Metformin may enhance the osteogenic differentiation of PDLSCs under high glucose by downregulating NPR3 expression and inhibiting the downstream MAPK pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Correction
Engineering, Biomedical
Xiao-Tao He, Rui-Xin Wu, Xin-Yue Xu, Jia Wang, Yuan Yin, Fa-Ming Chen
ACTA BIOMATERIALIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yang Yang, Yi Tian, Li-Juan Sun, Hong -Lei Qu, Zhi-Bang Li, Bei-Min Tian, Fa-Ming Chen
Summary: This study aimed to investigate the influence of anatomic characteristics of asymptomatic third molars (As-M3s) on distal pathologies of adjacent second molars (Ad-M2s). The results showed that both impacted and nonimpacted As-M3s increased the risk of distal pathologies in Ad-M2s. Within nonimpacted M3s, mandibular regions increased the risk of pocket depth, while wide dental intervals increased the risk of alveolar bone loss. However, maxillary regions and narrow dental intervals contributed to more severe bone loss in Ad-M2s.
INTERNATIONAL DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Beimin Tian, Xuan Li, Jiujiu Zhang, Meng Zhang, Dian Gan, Daokun Deng, Lijuan Sun, Xiaotao He, Chengtie Wu, Faming Chen
Summary: The study found that molybdenum ions can facilitate bone repair by comodulating the balance between bone formation and resorption. A molybdenum-containing scaffold was able to stimulate osteogenic differentiation and inhibit osteoclastic differentiation, leading to enhanced bone regeneration. These findings suggest that molybdenum ions are multifunctional cellular modulators with potential applications in biomaterial design and bone tissue engineering.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Correction
Cell & Tissue Engineering
Huan Zhou, Xuan Li, Yuan Yin, Xiao-Tao He, Ying An, Bei-Min Tian, Yong-Long Hong, Li-An Wu, Fa-Ming Chen
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Hong-Lei Qu, Li-Juan Sun, Xuan Li, Fen Liu, Hai-Hua Sun, Xiao-Tao He, Dian Gan, Yuan Yin, Bei-Min Tian, Fa-Ming Chen, Rui-Xin Wu
Summary: This study investigated the impact of excessive fat accumulation on the development and recovery of periodontitis. It found that exposure to abundant palmitic acid (PA) compromised the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). AC018926.2 was identified as a crucial regulator in PA-mediated osteogenic differentiation through upregulating ITGA2 expression and activating ITGA2/FAK/AKT signaling.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Daokun Deng, Xuan Li, Jiu-Jiu Zhang, Yuan Yin, Yi Tian, Dian Gan, Ruixin Wu, Jia Wang, Bei-Min Tian, Fa-Ming Chen, Xiao-Tao He
Summary: A simple and versatile method was developed to immobilize mesenchymal stem cell-derived exosomes (MSC-EXs) into hydrogels for sustained release and regenerative therapy. The MSC-EXs were immobilized in biotin-modified gelatin methacryloyl (Bio-GelMA) hydrogels via streptavidin, providing sustained release of MSC-EXs and promoting wound healing and regeneration.
Article
Biochemistry & Molecular Biology
Honglei Qu, Yang Yang, Yi Tian, Zhibang Li, Lijuan Sun, Faming Chen, Beimin Tian
Summary: This study investigated the perceptions and medical history of third molars (M3s) among 904 Chinese adults. The findings showed that nearly half of the participants had no knowledge about M3s, and only a small percentage provided correct answers. Male sex, older age, occupation involving physical labor, and no previous dental experience were associated with unawareness of M3s. Male sex was also related to the presence of visible M3s and negative behavior towards symptomatic M3s. This study highlights the lack of knowledge and negative attitudes towards M3s among the Chinese population.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)