Review
Cardiac & Cardiovascular Systems
Wern Yew Ding, Dhiraj Gupta, Christopher F. Wong, Gregory Y. H. Lip
Summary: Atrial fibrillation and chronic kidney disease are closely related conditions with complex interlinking mechanisms, requiring careful management and treatment for patients with both diseases.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Tasuku Yamamoto, Shinsuke Miyazaki, Yasuaki Tanaka, Toshikazu Kono, Tadanori Nakata, Akira Mizukami, Daisetsu Aoyama, Hirofumi Arai, Yuta Taomoto, Tomoki Horie, Rintaro Hojo, Shiho Kawamoto, Kento Yabe, Kikou Akiyoshi, Nobutaka Kato, Yuichi Ono, Atsushi Suzuki, Seiji Fukamizu, Yasutoshi Nagata, Yasuteru Yamauchi, Hiroshi Tada, Hitoshi Hachiya, Osamu Inaba, Atsushi Takahashi, Masahiko Goya, Tetsuo Sasano
Summary: This study aimed to investigate the anticoagulation management in ESKD patients undergoing AF ablation. The results showed that most patients had subtherapeutic INR values before and after the procedure, with a higher incidence of post-procedural bleeding events and rare thromboembolic events.
Article
Cardiac & Cardiovascular Systems
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: This study suggests that atrial fibrillation may lead to decreased kidney function and increased risk of chronic kidney disease.
EUROPEAN HEART JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Ville Kyto, Antti Saraste, Paivi Rautava, Aleksi Tornio
Summary: The use of digoxin after myocardial infarction is associated with increased mortality in patients with atrial fibrillation, but not with HF hospitalizations, new MI, or stroke.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Heather S. Jameson, Alan Hanley, Matthew C. Hill, Ling Xiao, Jiangchuan Ye, Aneesh Bapat, Elsa Ronzier, Amelia Weber Hall, William J. Hucker, Sebastian Clauss, Miranda Barazza, Elizabeth Silber, Julie A. Mina, Nathan R. Tucker, Robert W. Mills, Jin-Tang Dong, David J. Milan, Patrick T. Ellinor
Summary: This study identified the causative genetic variation related to atrial fibrillation (AF) at the ZFHX3 locus and explored the impact of Zfhx3 loss on cardiac function in mice. The results showed that ZFHX3 is the causative gene for AF at the 16q22 locus and its loss leads to cardiac abnormalities and dysregulation of atrial-specific pathways involved in AF susceptibility.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study suggests that atrial fibrillation may be a causal risk factor for kidney function impairment, but no effect of kidney function on atrial fibrillation was identified in the study.
EUROPEAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Szymon Bus, Konrad Jedrzejewski, Przemyslaw Guzik
Summary: The cross-strait relations have always been one of the most concerning issues for Chinese leaders and people. We adhere to the one-China principle, promote the development of cross-strait relations, and strive for the well-being of compatriots on both sides, aiming to achieve peaceful reunification.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lukasz Kuzma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Malgorzata Zalewska-Adamiec, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Marlena Kwiatkowska, Jolanta Malyszko
Summary: Patients with atrial fibrillation (AF) scheduled for coronary angiography are at higher risk of post-contrast acute kidney injury (PC-AKI), especially those with chronic kidney disease (CKD). This study found that kidney impairment was twice as common in AF patients undergoing coronary angiography, highlighting the need for extra caution in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Mark D. McCauley, Jesse Y. Hsu, Ana C. Ricardo, Dawood Darbar, Mayank Kansal, Manjula Kurella Tamura, Harold I. Feldman, John W. Kusek, Jonathan J. Taliercio, Panduranga S. Rao, Tariq Shafi, Jiang He, Xue Wang, Daohang Sha, Melissa Lamar, Alan S. Go, Kristine Yaffe, Mahboob Rahman, Raymond R. Townsend, Xue Wang, James P. Lash
Summary: In adults with chronic kidney disease, incident atrial fibrillation does not appear to be significantly associated with changes in cognitive function over time.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel E. Harris, Daniel Thayer, Ting Wang, Caroline Brooks, Geoff Murley, Mike Gravenor, Nathan R. Hill, Steven Lister, Julian Halcox
Summary: Using the UK NICE criteria, acceptable INR control is found to be poor among patients on warfarin. Even among those with an acceptable TTR (>65%), a quarter still had unacceptably low or high INR levels by NICE standards. Female gender, age (>=75 years), excess alcohol consumption, diabetes, heart failure, ischemic heart disease, and respiratory disease were independently associated with all markers of poor INR control.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Transplantation
Samantha Hayward, Barnaby Hole, Rachel Denholm, Polly Duncan, James E. Morris, Simon D. S. Fraser, Rupert A. Payne, Paul Roderick, Nicholas C. Chesnaye, Christoph Wanner, Christiane Drechsler, Maurizio Postorino, Gaetana Porto, Maciej Szymczak, Marie Evans, Friedo W. Dekker, Kitty J. Jager, Fergus J. Caskey
Summary: Hyperpolypharmacy is common among older people with advanced CKD, with significant international differences in the number of prescribed medications. Practice variation may represent a lack of consensus regarding appropriate prescribing for this high-risk group for whom pharmacological treatment has great potential for harm as well as benefit.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Joonatan Palmu, Christin S. Boerschel, Alfredo Ortega-Alonso, Lajos Marko, Michael Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel
Summary: This study found that the gut microbiome composition is associated with the risk of atrial fibrillation (AF). Certain microbial genera were found to be related to the occurrence and prediction of AF. These findings establish the basis for using microbiome profiling in predicting AF risk, but further research is needed before microbiome sequencing can be used in prevention and targeted treatment of AF.
Article
Cardiac & Cardiovascular Systems
Sean D. Pokorney, Glenn M. Chertow, Hussein R. Al-Khalidi, Dianne Gallup, Pat Dignacco, Kurt Mussina, Nisha Bansal, Crystal A. Gadegbeku, David A. Garcia, Samira Garonzik, Renato D. Lopes, Kenneth W. Mahaffey, Kelly Matsuda, John P. Middleton, Jennifer A. Rymer, George H. Sands, Ravi Thadhani, Kevin L. Thomas, Jeffrey B. Washam, Wolfgang C. Winkelmayer, Christopher B. Granger
Summary: This study evaluated the safety and efficacy of apixaban for stroke prevention in patients with end-stage kidney disease on hemodialysis and atrial fibrillation. The trial showed no significant difference in major or clinically relevant nonmajor bleeding between apixaban and warfarin, and there was overlap in apixaban blood concentration between patients with and without bleeding events. Future randomized studies are needed to assess the risks and benefits of anticoagulation in this population.
Article
Pharmacology & Pharmacy
M. Sabate, X. Vidal, E. Ballarin, M. Rottenkolber, S. Schmiedl, B. Grave, C. Huerta, E. Martin-Merino, D. Montero, L. M. Leon-Munoz, C. Gasse, N. Moore, C. Droz, R. Lassalle, M. Aakjaer, M. Andersen, M. L. De Bruin, P. Souverein, O. H. Klungel, H. Gardarsdottir, L. Ibanez
Summary: This study described and compared the adherence to different direct oral anticoagulants (DOACs) in eight European databases representing six countries. Despite differences in database characteristics and population demographics, a similar pattern was observed with apixaban having the highest persistence and dabigatran having the highest rates of discontinuation and switching at 12 months in most databases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ching-Lung Cheung, Chor-Wing Sing, Wallis C. Y. Lau, Gloria H. Y. Li, Gregory Y. H. Lip, Kathryn C. B. Tan, Bernard M. Y. Cheung, Esther W. Y. Chan, Ian C. K. Wong
Summary: The study found that among adults with AF receiving OACs, the use of dabigatran was associated with the lowest risk of diabetes compared to warfarin use, while the risk of diabetes with apixaban and rivaroxaban use was not statistically significant.
CARDIOVASCULAR DIABETOLOGY
(2021)
