期刊
CARDIOVASCULAR RESEARCH
卷 117, 期 4, 页码 1046-1059出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvaa258
关键词
Atrial fibrillation; Chronic kidney disease; Renal failure; Kidney impairment; Pathophysiology; Thromboembolism; Stroke; Anticoagulation; VKA; Warfarin; NOAC; Bleeding
Atrial fibrillation and chronic kidney disease are closely related conditions with complex interlinking mechanisms, requiring careful management and treatment for patients with both diseases.
Atrial fibrillation (AF) and chronic kidney disease (CKD) are closely related conditions with shared risk factors. The growing prevalence of both AF and CKD indicates that more patients will suffer from concurrent conditions. There are various complex interlinking mechanisms with important implications for the management of these patients. Furthermore, there is uncertainty regarding the use of oral anticoagulation (OAC) in AF and CKD that is reflected by a lack of consensus between international guidelines. Therefore, the importance of understanding the implications of co-existing AF and CKD should not be underestimated. In this review, we discuss the pathophysiology and association between AF and CKD, including the underlying mechanisms, risk of thrombo-embolic and bleeding complications, influence on stroke management, and evidence surrounding the use of OAC for stroke prevention.
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