Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

Hesperetin nanoparticles attenuate anxiogenic-like behavior and cerebral oxidative stress through the upregulation of antioxidant enzyme expression in experimental dementia of Alzheimer’s type

(2020) Akbar Hajizadeh Moghaddam et al.   NEUROLOGICAL RESEARCH

Potential effect of herbal antidepressants on cognitive deficit: Pharmacological activity and possible molecular mechanism

(2020) Jian-Mei Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

(2019) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety

(2019) Ying Bai et al.   MOLECULES

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

(2019) Subrat Kumar Bhattamisra et al.   Biomolecules

Hybrid Compounds & Oxidative Stress Induced Apoptosis In Cancer Therapy

(2018) Aysegul Hanikoglu et al.   CURRENT MEDICINAL CHEMISTRY

Piperlongumine inhibits neuroinflammation via regulating NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells

(2018) Namkwon Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder

(2018) Douglas Teixeira Leffa et al.   NEUROIMMUNOMODULATION

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line

(2018) Longtai You et al.   Frontiers in Pharmacology

Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway

(2018) Kpobari W. Nkpaa et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis

(2017) Xia-wei Zheng et al.   Oxidative Medicine and Cellular Longevity

Decreased Glial GABA and Tonic Inhibition in Cerebellum of Mouse Model for Attention-Deficit/Hyperactivity Disorder (ADHD)

(2017) Yoo Sung Kim et al.   Experimental Neurobiology

Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway

(2016) L.-a. Hu et al.   BIOSCIENCE REPORTS

Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis

(2016) MING SHU et al.   Molecular Medicine Reports

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Developing drug strategies for the neuroprotective treatment of acute ischemic stroke

(2015) Antonino Tuttolomondo et al.   Expert Review of Neurotherapeutics

Ethanolic extract of Tulipa edulis Bak induces apoptosis in SGC-7901 human gastric carcinoma cells via the mitochondrial signaling pathway

(2015) RUHUI LIN et al.   Oncology Letters

Developing drug strategies for the neuroprotective treatment of acute ischemic stroke

(2015) Antonino Tuttolomondo et al.   Expert Review of Neurotherapeutics

Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells

(2014) Xiaohua Jin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

(2013) Paulina Tokarz et al.   BIOGERONTOLOGY

Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation

(2013) Fei Zhao et al.   PLoS One

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures

(2012) Jing Bi et al.   TOXICOLOGY IN VITRO

Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

(2009) Lingai Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa

(2008) Xiuli Zhang et al.   PHYTOMEDICINE

Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

(2007) Kyung-Jin Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY