Review
Neurosciences
Jaya Dilip Badadhe, Hyeonhee Roh, Byung Chul Lee, Jae Hun Kim, Maesoon Im
Summary: Globally, there are over 2.2 billion visually impaired individuals, and ultrasound stimulation can serve as a non-invasive alternative approach to restore vision. Recent studies have demonstrated that ultrasound stimulation can successfully modulate retinal/brain neuronal activities without causing any damage to nerve cells. The superior penetration depth and high spatial resolution of focused ultrasound can open new avenues in neuromodulation research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Amber Maimon, Or Yizhar, Galit Buchs, Benedetta Heimler, Amir Amedi
Summary: The paper discusses the unique phenomenological experience of a man who became blind in adulthood and underwent training with both an Argus II retinal prosthesis and the EyeMusic sensory substitution device. The man reports that the sensory substitution device provided a richer and more natural perceptual experience compared to the retinal prosthesis. Long-term use of the sensory substitution device resulted in a higher level of automaticity. The combination of both devices also enhanced the user's subjective visual experience.
Article
Chemistry, Analytical
Chenlin Xu, Gengxi Lu, Haochen Kang, Mark S. Humayun, Qifa Zhou
Summary: This paper introduces a novel design and simulation of a non-invasive ultrasonic retinal stimulation device, which can acoustically couple with the eye via the tear film and trigger the activities of retinal neurons with high spatial-temporal resolution. Compared with other retinal prostheses, this ultrasound ring array is shown to be practical and safe.
Article
Multidisciplinary Sciences
David Avraham, Yitzhak Yitzhaky
Summary: This study aimed to improve the restoration effect of retinal prostheses on vision for blind individuals using object isolation algorithm and image processing techniques. The results indicated an enhancement in perceived shape, contrast, and dynamic range of objects in the phosphene image.
Article
Engineering, Biomedical
David Avraham, Jae-Hyun Jung, Yitzhak Yitzhaky, Eli Peli
Summary: The perception of individuals fitted with retinal prostheses is not fully understood. Realistic simulations of perception with retinal implants would be useful for future development and evaluation of such systems. The temporal aspects in prosthetic vision play important roles, as illustrated by the simulations, and considering these aspects may improve the future design, training with, and evaluation of retinal prostheses.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Vernon L. Towle, Tuan Pham, Michael McCaffrey, Danielle Allen, Philip R. Troyk
Summary: This study discusses the advantages of color prosthetic systems in reducing the likelihood of epileptic seizures. A 'hybrid' mode of stimulation is proposed to provide both B/W and color stimulation, to obtain color information without reducing spatial resolution. Software implementation strategies are discussed, along with the advantages and challenges of possible color prosthetic systems.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Neurosciences
Jiajia Wu, Corey M. Rountree, Sai-Siva Kare, Pradeep Kumar Ramkumar, John D. Finan, John B. Troy
Summary: This article reviews the progress in chemical retinal prosthesis research over the past decade, discussing its advantages, resolution, materials, and biocompatibility, while considering potential issues.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Acoustics
Gengxi Lu, Xuejun Qian, Chen Gong, Jie Ji, Biju B. Thomas, Mark S. Humayun, Qifa Zhou
Summary: Ultrasound neuromodulation is an emerging technology that has shown promise in activating healthy and degenerated retinas. This review article summarizes pilot studies on ultrasound retinal stimulation, compares it with other neuromodulation technologies, and discusses the advantages and limitations of using high-frequency ultrasound for developing a noninvasive retinal prosthesis. Opportunities and challenges in this field are also highlighted.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Review
Engineering, Biomedical
Susana Moleirinho, Andrew J. Whalen, Shelley Fried, John S. Pezaris
Summary: The development of visual prosthesis devices faces challenges in understanding factors such as phosphenes and how electrical patterns influence phosphenes generation. Research on synchronous and asynchronous electrical stimulation across multiple electrodes is crucial for creating a clinically successful prosthesis.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Take Matsuyama, Hung-Ya Tu, Jianan Sun, Tomoyo Hashiguchi, Ryutaro Akiba, Junki Sho, Momo Fujii, Akishi Onishi, Masayo Takahashi, Michiko Mandai
Summary: Genetically engineered mouse ESC/iPSC-retinal sheet transplantation can restore visual function in mice, establish synaptic connections, reduce aberrant retinal ganglion cell spiking, and contribute to better visual recovery by improving neural integration.
Article
Multidisciplinary Sciences
Wanying Li, Shan Qin, Yijie Lu, Hao Wang, Zhen Xu, Tianzhun Wu
Summary: The study utilized biphasic voltages to stimulate retinal ganglion cells and developed an automatic algorithm for data processing, revealing an optimal pulse amplitude range of 0.43 V to 1.3 V with consistent results to manual processing.
Article
Neurosciences
Amber Maimon, Ophir Netzer, Benedetta Heimler, Amir Amedi
Summary: In this study, a group of children who have undergone vision-restoring cataract removal surgery were tested on various visual perception tasks to understand their unique experiences. The findings support and raise questions about critical periods theory and the ability to quickly correlate vision with touch. The study also highlights the importance of geometry perception abilities independent of visual experience and proposes a new method to determine early vs. late blindness.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Computer Science, Information Systems
Sida Li, Ye Liu
Summary: In this study, a cross-resolution perceptual experiences transfer framework is proposed for categorizing high-resolution aerial photos. By leveraging the perceptual features from low-resolution aerial photos to enhance the feature selection of high-resolution ones, the technique for categorizing a rich variety of high-resolution aerial photos is achieved.
Article
Neurosciences
Puti Wen, Michael S. Landy, Bas Rokers
Summary: Accurate motion perception requires integration of 2D retinal motion signals from the two eyes into a single representation of 3D motion. However, existing paradigms are unable to distinguish 3D head-centric motion from 2D retinal motion. This study used stereoscopic displays and fMRI to investigate the representation of separate motion signals in the visual cortex. The results showed that early visual cortex represents 2D retinal motion signals, while hMT and IPS0 are critical for the transformation of retinal into 3D head-centric motion signals.
Article
Engineering, Biomedical
Hyeonhee Roh, Yanjinsuren Otgondemberel, Maesoon Im
Summary: This study systematically explored network-mediated responses that arise from various short pulses in both normal and degenerate retinas. The results showed that short pulses elicited strong network-mediated responses in both healthy and degenerate retinas. The response of ON RGCs was highly dependent on the current amplitude, while the response of OFF RGCs was more influenced by the number of stimuli.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Joonsoo Jeong, Farah Laiwalla, Jihun Lee, Riina Ritasalo, Marko Pudas, Lawrence Larson, Vincent Leung, Arto Nurmikko
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Computer Science, Information Systems
Seunghyeon Yun, Chin Su Koh, Joonsoo Jeong, Jungmin Seo, Seung-Hee Ahn, Gwang Jin Choi, Shinyong Shim, Jaewoo Shin, Hyun Ho Jung, Jin Woo Chang, Sung June Kim
Article
Computer Science, Information Systems
Seonghoon Jo, Kyungsik Eom
Article
Multidisciplinary Sciences
Chae Hyun Kim, Dong Hyeon Lee, Jiman Youn, Hongje Lee, Joonsoo Jeong
Summary: The study proposes a simple, rapid, cost-effective, and complete microfabrication process for flexible and stretchable sensor platforms, including conductor formation and patterning, as well as encapsulation and opening of sensing windows. This method can stably create microscale features suitable for various wearable applications.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Jungwoo Jang, Changhoon Baek, Sunhyo Kim, Tae-Kyeong Lee, Gwang-Jin Choi, Shinyong Shim, Seunghyeon Yun, Younginha Jung, Chae-Eun Lee, Seunghyung Ko, Kangmoon Seo, Jong-Mo Seo, Moo-Ho Won, Sung J. Kim, Yoon-Kyu Song
Summary: Research efforts to understand and modulate sensory and motor skills in animals have shown promising results, particularly in rodents. However, in the case of birds, the brain nuclei responsible for controlling movements are still unclear. By implanting electrode arrays and electrically stimulating pigeon brains, it was discovered that certain nuclei could induce specific flight behaviors in pigeons.
Review
Chemistry, Analytical
Younghoon Park, Sung-Yun Park, Kyungsik Eom
Summary: Neural interfaces, crucial in understanding the brain and serving as neural prostheses, have traditionally been based on electrical transduction. However, optical methods have gained attention for their high spatial selectivity and decreased invasiveness in connecting neurons to the external world. This review discusses the current state-of-art of optical neural interfaces, dividing them into optical control and optical readout categories and comparing their relative performance.
Article
Computer Science, Information Systems
Hyeon-June Kim, Younghoon Park, Kyungsik Eom, Sung-Yun Park
Summary: A novel AC-coupled modular 16-channel analog frontend has been introduced for multichannel recording of broadband neural signals with improved performance and efficiency through the use of a new OTA design and optimized parameters.
Article
Chemistry, Analytical
Seunghyeon Yun, Chin Su Koh, Jungmin Seo, Shinyong Shim, Minkyung Park, Hyun Ho Jung, Kyungsik Eom, Jin Woo Chang, Sung June Kim
Summary: This article describes a fully implantable miniaturized spinal cord stimulator based on a biocompatible liquid crystal polymer (LCP). The stimulator suppresses pain signals by electrically stimulating the spinal cord. Compared to traditional metal packaged and battery-operated stimulators, this LCP-based device is smaller and lighter, allows wireless power and data transfer, and has shown effective pain suppression in animal models.
Article
Engineering, Electrical & Electronic
Jae In Kim, Dong Hyeon Lee, Byungjin Kim, Yoo-Kyum Shin, Sang-Min Kim, Hongje Lee, Min-Ho Seo, Joonsoo Jeong
Summary: This study demonstrates a simple, rapid, and cost-effective microfabrication process based on transfer printing without the need for MEMS processing or sophisticated transfer control. The adhesion properties of PDMS are tuned using PEIE, allowing for easy transfer of thin sensor patterns. The optimized microfabrication steps enable stable fabrication of thin gold lines. This process also enables adhesive-free attachment to the skin without losing its adhesion forces over repeated applications.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Engineering, Biomedical
Kyungmo Sung, Seonghoon Jo, Jaewook Lee, Jeong Hoan Park, Young Hoon Park, Jeongjoo Moon, Sung June Kim, Joonsoo Jeong, Jonghwan Lee, Kyungsik Eom
Summary: Heating nanoparticles with a magnetic field enables selective remote control of deep tissue neural activity. A study investigated multichannel magnetothermal stimulation using an array of resonant coils driven by a single loop coil. The design allowed for control of each coil's resonance, resulting in the selection of stimulation channels. Smaller inner diameters of the coils produced more localized magnetic fields, while larger coils had a longer range.
BIOMEDICAL ENGINEERING LETTERS
(2023)
Review
Engineering, Biomedical
Dong Hyeon Lee, Chae Hyun Kim, Jiman Youn, Joonsoo Jeong
Summary: This article summarizes the evaluation methods for long-term reliability of emerging biomedical implants based on polymeric thin-films, with a specific focus on the differences from traditional metallic packages.
BIOMEDICAL ENGINEERING LETTERS
(2021)