Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Aya Mousa, Kevin Huynh, Stacey J. Ellery, Boyd J. Strauss, Anju E. Joham, Barbora de Courten, Peter J. Meikle, Helena J. Teede
Summary: This study demonstrates that high levels of LPI(18:0) and low levels of DHA-containing lipids are associated with key metabolic risk factors in women with and without polycystic ovary syndrome (PCOS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Dan Tian, Wei Chen, Qing Xu, Xiaoyu Li, Qianzhou Lv
Summary: Liraglutide treatment significantly improves waist circumference, BMI, weight, and insulin resistance in obese women with PCOS, with a potential effect on FSH and LH but with high heterogeneity.
Article
Medicine, General & Internal
Rui-Lin Ma, Yan Deng, Yan-Fang Wang, Shi-Yang Zhu, Xue-Song Ding, Ai-Jun Sun
Summary: The study demonstrated that once-weekly exenatide combined with MET was more effective than MET alone in overweight/obese women with PCOS, leading to weight reduction, improvement in BMI and waist circumference, and enhanced insulin sensitivity, with acceptable short-term side effects.
CHINESE MEDICAL JOURNAL
(2021)
Review
Obstetrics & Gynecology
Suleyman N. Sendur, Bulent O. Yildiz
Summary: The clinical presentation and treatment outcomes of patients with PCOS vary significantly among different ethnicities, including differences in hirsutism, hormone levels, body weight, and insulin resistance. These variations show distinct differences among ethnic groups in the clinical phenotype of PCOS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Ki-Jin Ryu, Min Sun Kim, Hyun Kyun Kim, Yong Jin Kim, Kyong Wook Yi, Jung Ho Shin, Jun Young Hur, Tak Kim, Hyuntae Park
Summary: This study found that PCOS is independently associated with an increased incidence of T2DM in Korean women, regardless of obesity status. Screening for T2DM should be considered for Korean women with PCOS.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
Shayaq Ul Abeer Rasool, Mudasar Nabi, Sairish Ashraf, Shajrul Amin
Summary: This study investigated the association between IRS-1Gly972Arg (rs1801278) polymorphism and the risk of PCOS in Kashmiri women. The results showed that this genetic variant does not increase the risk of PCOS, but is associated with clinical manifestations of insulin resistance, obesity, and hyperandrogenism.
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Applied
Lin Ni, Jingxin Chen, Xiaoqin Zhang, Meiting Wu, Linjing Zhang, Zujian Wu, Mingqing Huang, Huiyou Xu
Summary: Two new alkaloids, hositisines A and B, along with two known alkaloids, were isolated from the stems of Ormosia hosiei Hemsl. et Wils. The compounds showed strong protective effects on PC12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) injury, by significantly reducing LDH release.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Analytical
Mingcheng Ren, Wen Xu, Yiping Zhang, Lin Ni, Yifan Lin, Xiaoqin Zhang, Mingqing Huang
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Chemistry, Applied
Le-Le Zhang, Mu-Yang Huang, Yong Yang, Ming-Qing Huang, Jia-Jie Shi, Liang Zou, Jin-Jian Lu
Article
Integrative & Complementary Medicine
Xiao-Kang Jia, Jin-Fang Huang, Xiao-Qiang Huang, Xiao-Yan Li, Ming-Qing Huang, Huai-Chang Zhu, Gao-Pan Li, Meng-Liu Lan, Zhi-Wen Yu, Wen Xu, Shui-Sheng Wu
Summary: The study aimed to evaluate the effects of Alismatis rhizoma triterpenes on insulin resistance in mice and C2C12 cells. Results showed that AR alleviated insulin resistance in skeletal muscle of mice, and this effect was further validated by AR triterpenes. The study demonstrated that AR triterpenes have a notable effect on insulin resistance by regulating gene expression, with triterpenes serving as the material basis for this activity.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen, Jin-Jian Lu
Summary: This article reviews the anticancer effects of ginsenoside Rh2 and summarizes its mechanisms and therapeutic effects, aiming to promote the clinical application of this natural product.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaokang Jia, Huaichang Zhu, Gaopan Li, Mengliu Lan, Xiaoyan Li, Mingqing Huang, Wen Xu, Shuisheng Wu
Summary: Alisol C 23-acetate (AC23A) derived from Alismatis rhizoma (AR) has anti-inflammatory and metabolic disease ameliorating effects, and shows inhibitory effects on osteoclastogenesis in vitro and in vivo by suppressing RANKL-induced osteoclast differentiation and function, suggesting its potential in preventing or limiting bone diseases mediated by osteoclasts.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Huai-Chang Zhu, Xiao-Kang Jia, Yong Fan, Shao-Hua Xu, Xiao-Yan Li, Ming-Qing Huang, Meng-Liu Lan, Wen Xu, Shui-Sheng Wu
Summary: This study demonstrated that AB23A intervention effectively prevented colitis-associated cancer in male mouse models by reducing body weight loss, disease activity index, colon tumor load, tissue injury, and inflammatory cytokine changes. AB23A also decreased the activation of TLR, NF-kappa B, and MAPK pathways, while increasing the expression of mucin-2 and tight junction proteins. Additionally, AB23A interference led to alterations in gut microbiota composition with reduced levels of pathogenic bacteria and increased levels of beneficial bacteria. These findings suggest that AB23A has potential for future use in treating colitis-associated cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhenwei Huang, Xian Zhou, Xiaoqin Zhang, Lili Huang, Yibin Sun, Zaixing Cheng, Wen Xu, Chun-Guang Li, Yanfang Zheng, Mingqing Huang
Summary: The study demonstrated that the traditional Chinese medicine Pien-Tze-Huang (PTH) can inhibit NLRP3 inflammasome-mediated neuroinflammation through enhancing autophagy and the AMPK/mTOR/ULK1 pathway both in vitro and in vivo, which was validated in experiments with cell cultures and rat models.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Analytical
Zaixing Cheng, Shi Zhuo, Shuang Guo, Jian Liu, Xiaoqin Zhang, Jiumao Lin, Mingqing Huang
Summary: Ba-Bao-Dan (BBD) is a well-known Traditional Chinese medicine prescription, widely used for treating various diseases. This study established a new analytical method and identified potential chemical markers for quality control of BBD through the combination with chemometrics.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Applied
Linjing Zhang, Lijun Zheng, Qin Wang, Zhenze Pana, Xiaoqin Zhang, Mingqing Huang, Huiyou Xu, Lin Ni
Summary: Two new cytisine-like alkaloids, hositisines C and D, were isolated from the seeds of Ormosia hosiei, along with four known compounds. Their structures were determined using various spectroscopic techniques. In cytotoxic activity testing, compounds 1-3 and 5-fluorouracil showed inhibitory effects against HepG2 cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Yaxin Chen, Niaoniao He, Ting Yang, Shuyun Cai, Yi Zhang, Jinjing Lin, Mingqing Huang, Weizhu Chen, Yiping Zhang, Zhuan Hong
Summary: In this study, a solid lipid nanoparticle-microcapsule delivery system was creatively constructed to encapsulate fucoxanthin (FX), aiming to improve its stability and bioavailability. The encapsulated FX showed higher storage stability, sustained release, and significantly improved bioavailability compared to free FX. The research results provide a theoretical basis for the development and application of FX in pharmaceuticals or functional foods.
Article
Spectroscopy
Hongyan Zhang, Weiwei Mao, Yijin Hu, Xiaohong Wei, Lishan Huang, Shen Fan, Mingqing Huang, Yu Song, Yuyan Yu, FengFu Fu
Summary: A highly sensitive and specific visual detection method for aflatoxin B1 (AFB1) has been developed based on the combination of aptamer, rolling circle amplification (RCA), and enzyme catalysis. The method can achieve a wide linear detection range and low detection limit, and exhibits excellent specificity in complex sample matrices, showing great potential for practical AFB1 detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Jian-Yu Chen, Ying-Jie Yang, Xue-Qin Ma, Qi Cao, Shan-Shan Wei, Rong-Rong Pan, Li-Hong Nan, Yao-Jun Liu, Yan Cao, Xiao-Yun Tian, Shan Deng, Zai-Xing Cheng, Can-Jian Wang, Tao Chen, Yan-Fang Zheng, Ming-Qing Huang
Summary: Huangqin, a Chinese medicinal herb, and its active compound Neobaicalein have been shown to have anti-inflammatory effects. This study found that Neobaicalein specifically inhibits the differentiation of Th17 cells by blocking the STAT3 signaling pathway, indicating its potential for treating autoimmune inflammatory diseases.
Article
Plant Sciences
Xiaoqin Zhang, Qing Zhang, Lili Huang, Mingzhen Liu, Zaixing Cheng, Yanfang Zheng, Wen Xu, Jinjian Lu, Jian Liu, Mingqing Huang
Summary: This study demonstrated that Pien-Tze-Huang can significantly reduce cerebral infarct volume, improve neurological function, and alleviate brain histopathological damage in rats with cerebral ischaemia-reperfusion injury. Pien-Tze-Huang may improve cerebral ischaemia-reperfusion injury by inhibiting neuroinflammation through a specific pathway.
PHARMACEUTICAL BIOLOGY
(2021)