Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum

(2019) Xiaoli Wang et al.   Parasites & Vectors

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

The nanomolar sensing of nicotinamide adenine dinucleotide in human plasma using a cycling assay in albumin modified simulated body fluids

(2018) Philipp Brunnbauer et al.   Scientific Reports

CD38: A Target for Immunotherapeutic Approaches in Multiple Myeloma

(2018) Fabio Morandi et al.   Frontiers in Immunology

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Schistosomiasis vaccines: where do we stand?

(2016) Biniam Mathewos Tebeje et al.   Parasites & Vectors

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Lactate as a Novel Quantitative Measure of Viability in Schistosoma mansoni Drug Sensitivity Assays

(2014) Stephanie Howe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting NAD+ Metabolism in the Human Malaria Parasite Plasmodium falciparum

(2014) Jessica K. O'Hara et al.   PLoS One

Inhibition or Knockdown of ABC Transporters Enhances Susceptibility of Adult and Juvenile Schistosomes to Praziquantel

(2014) Ravi S. Kasinathan et al.   PLoS Neglected Tropical Diseases

Schistosome Feeding and Regurgitation

(2014) Patrick J. Skelly et al.   PLoS Pathogens

NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity

(2013) Sathisha Upparahalli Venkateshaiah et al.   EXPERIMENTAL HEMATOLOGY

Warburg effect increases steady-state ROS condition in cancer cells through decreasing their antioxidant capacities (Anticancer effects of 3-bromopyruvate through antagonizing Warburg effect)

(2013) Salah Mohamed El Sayed et al.   MEDICAL HYPOTHESES

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

(2013) Carles Cantó et al.   MOLECULAR ASPECTS OF MEDICINE

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

(2013) Julien Lancelot et al.   PLoS Neglected Tropical Diseases

Domain enhanced lookup time accelerated BLAST

(2012) Grzegorz M Boratyn et al.   Biology Direct

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

(2012) M. Cea et al.   BLOOD

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

(2012) P. O. Ljungdahl et al.   GENETICS

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+Biosynthesis, in Human Cancer Cells

(2012) Bo Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of curcumin on the parasite Schistosoma mansoni: A transcriptomic approach

(2012) Enyara R. Morais et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Glutamine versus Ammonia Utilization in the NAD Synthetase Family

(2012) Jessica De Ingeniis et al.   PLoS One

A review of female genital schistosomiasis

(2012) Eyrun F. Kjetland et al.   TRENDS IN PARASITOLOGY

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

Fatty Acid Oxidation Is Essential for Egg Production by the Parasitic Flatworm Schistosoma mansoni

(2012) Stanley Ching-Cheng Huang et al.   PLoS Pathogens

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation

(2011) E. Gazanion et al.   MOLECULAR MICROBIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of a Regulatory Segment of Poly(ADP-ribose) Glycohydrolase

(2010) Davide Botta et al.   BIOCHEMISTRY

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

(2010) Nicolas Guex et al.   ELECTROPHORESIS

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor

(2010) U. H. Olesen et al.   MOLECULAR CANCER THERAPEUTICS

Synthesizing and Salvaging NAD+: Lessons Learned from Chlamydomonas reinhardtii

(2010) Huawen Lin et al.   PLoS Genetics

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

(2009) A. Nahimana et al.   BLOOD

Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans

(2009) T. L. Vrablik et al.   DEVELOPMENT

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

(2009) Santina Bruzzone et al.   PLoS One

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark