A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

(2019) Gabriel Balmus et al.   Nature Communications

UFL1 promotes histone H4 ufmylation and ATM activation

(2019) Bo Qin et al.   Nature Communications

MRE11 UFMylation promotes ATM activation

(2019) Zhifeng Wang et al.   NUCLEIC ACIDS RESEARCH

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

(2019) Watson P. Folk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

(2018) Zhiming Li et al.   CELL RESEARCH

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

(2018) Stephen T. Durant et al.   Science Advances

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM

(2017) Yi Zhou et al.   MOLECULAR CELL

Long Noncoding RNAs in Cancer Pathways

(2016) Adam M. Schmitt et al.   CANCER CELL

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

(2015) Nuala McCabe et al.   CANCER RESEARCH

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

Phosphorylation of p53 by TAF1 Inactivates p53-Dependent Transcription in the DNA Damage Response

(2013) Yong Wu et al.   MOLECULAR CELL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Reality of Pervasive Transcription

(2011) Michael B. Clark et al.   PLOS BIOLOGY

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Ionizing Radiation Induces Ataxia Telangiectasia Mutated-Dependent Checkpoint Signaling and G2But Not G1Cell Cycle Arrest in Pluripotent Human Embryonic Stem Cells

(2009) Olga Momčilović et al.   STEM CELLS

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY