Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement

(2019) Amy R. Johnson et al.   NEUROPSYCHOPHARMACOLOGY

Drug Overdose Deaths Among Women Aged 30–64 Years — United States, 1999–2017

(2019) Jacob P. VanHouten et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Male and female mice develop escalation of heroin intake and dependence following extended access

(2019) Eleanor B. Towers et al.   NEUROPHARMACOLOGY

Estradiol rapidly modulates excitatory synapse properties in a sex and region-specific manner in rat nucleus accumbens core and caudate-putamen

(2019) Amanda A Krentzel et al.   JOURNAL OF NEUROPHYSIOLOGY

Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area

(2019) Samara A.M. Bobzean et al.   NEUROSCIENCE LETTERS

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

(2019) Eric P. Zorrilla et al.   Frontiers in Behavioral Neuroscience

Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens

(2018) Katie E. Yoest et al.   HORMONES AND BEHAVIOR

Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

(2018) Katherine R. Tonn Eisinger et al.   HORMONES AND BEHAVIOR

Estrous cycle-induced sex differences in medium spiny neuron excitatory synaptic transmission and intrinsic excitability in adult rat nucleus accumbens core

(2018) Stephanie Proano et al.   JOURNAL OF NEUROPHYSIOLOGY

Sex differences in neural mechanisms mediating reward and addiction

(2018) Jill B. Becker et al.   NEUROPSYCHOPHARMACOLOGY

Prevention and Treatment of Opioid Misuse and Addiction

(2018) Nora D. Volkow et al.   JAMA Psychiatry

Sex-Dependent Effects of Stress on Immobility Behavior and VTA Dopamine Neuron Activity: Modulation by Ketamine

(2017) Millie Rincón-Cortés et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Untangling the web of opioid addictions in the USA

(2017) The Lancet   LANCET

Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens

(2017) Anna Brancato et al.   NEUROSCIENCE

Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol

(2017) Bertha J. Vandegrift et al.   PLoS One

Dopaminergic dynamics underlying sex-specific cocaine reward

(2017) Erin S. Calipari et al.   Nature Communications

Reflections on: “A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function”

(2016) Eric J. Nestler   BRAIN RESEARCH

Gonadectomy but not biological sex affects burst-firing in dopamine neurons of the ventral tegmental area and in prefrontal cortical neurons projecting to the ventral tegmentum in adult rats

(2016) Mallory N. Locklear et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory μ-opioid receptor adenylyl cyclase signaling

(2016) Sumita Chakrabarti et al.   JOURNAL OF NEUROCHEMISTRY

Sex differences, gender and addiction

(2016) Jill B. Becker et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine

(2016) Brittni M. Peterson et al.   NEUROPHARMACOLOGY

Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum

(2016) Anne Almey et al.   NEUROSCIENCE LETTERS

Misuse of Prescription Opioid Medication among Women: A Scoping Review

(2016) Natalie Hemsing et al.   Pain Research & Management

Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB

(2016) Christian Engelmann et al.   NEURAL PLASTICITY

Chronic cocaine disrupts mesocortical learning mechanisms

(2015) William C. Buchta et al.   BRAIN RESEARCH

Genetic sex and the volumes of the caudate-putamen, nucleus accumbens core and shell: original data and a review

(2015) Jordan E. Wong et al.   Brain Structure & Function

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females

(2015) Anne Almey et al.   HORMONES AND BEHAVIOR

Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons

(2015) David M. Dorris et al.   JOURNAL OF NEUROPHYSIOLOGY

Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal

(2015) J. Kaufling et al.   JOURNAL OF NEUROSCIENCE

Estradiol in the Preoptic Area Regulates the Dopaminergic Response to Cocaine in the Nucleus Accumbens

(2015) Daniel J Tobiansky et al.   NEUROPSYCHOPHARMACOLOGY

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine

(2015) Anna M W Taylor et al.   NEUROPSYCHOPHARMACOLOGY

The ins and outs of the striatum: Role in drug addiction

(2015) L.M. Yager et al.   NEUROSCIENCE

Silent Synapses Speak Up

(2015) Yanhua H. Huang et al.   NEUROSCIENTIST

Understanding opioid reward

(2015) Howard L. Fields et al.   TRENDS IN NEUROSCIENCES

Sex Differences between CRF1 Receptor Deficient Mice following Naloxone-Precipitated Morphine Withdrawal in a Conditioned Place Aversion Paradigm: Implication of HPA Axis

(2015) Juan-Antonio García-Carmona et al.   PLoS One

Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning.

(2014) Ceyhun Sunsay et al.   BEHAVIORAL NEUROSCIENCE

Estradiol facilitation of cocaine-induced locomotor sensitization in female rats requires activation of mGluR5

(2014) Luis A. Martinez et al.   BEHAVIOURAL BRAIN RESEARCH

Acute estradiol treatment affects the expression of cocaine-induced conditioned place preference in ovariectomized female rats

(2014) Samara A.M. Bobzean et al.   BRAIN RESEARCH BULLETIN

Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5

(2014) Brittni M. Peterson et al.   Brain Structure & Function

Sex differences in the neurobiology of drug addiction

(2014) Samara A.M. Bobzean et al.   EXPERIMENTAL NEUROLOGY

PPARγ Activation Attenuates Opioid Consumption and Modulates Mesolimbic Dopamine Transmission

(2014) Giordano de Guglielmo et al.   NEUROPSYCHOPHARMACOLOGY

Control of the Nigrostriatal Dopamine Neuron Activity and Motor Function by the Tail of the Ventral Tegmental Area

(2014) Romain Bourdy et al.   NEUROPSYCHOPHARMACOLOGY

Endogenous opiates and behavior: 2013

(2014) Richard J. Bodnar   PEPTIDES

Optogenetic insights into striatal function and behavior

(2013) Jeffrey D. Lenz et al.   BEHAVIOURAL BRAIN RESEARCH

Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression

(2013) Stephanie K. Nygard et al.   BRAIN RESEARCH

Estrogenic influences in pain processing

(2013) Åsa Amandusson et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving  FosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

(2013) A. J. Robison et al.   JOURNAL OF NEUROSCIENCE

 FosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

(2013) M. K. Lobo et al.   JOURNAL OF NEUROSCIENCE

Sex Differences in Opioid Analgesia and Addiction: Interactions among Opioid Receptors and Estrogen Receptors

(2013) Cynthia Wei-Sheng Lee et al.   Molecular Pain

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use

(2013) Roland Bock et al.   NATURE NEUROSCIENCE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

 FosB differentially modulates nucleus accumbens direct and indirect pathway function

(2013) B. A. Grueter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type

(2013) Helen C. Fox et al.   PSYCHONEUROENDOCRINOLOGY

Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse nucleus accumbens

(2013) Giuseppe Gangarossa et al.   Frontiers in Neural Circuits

Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1

(2013) Ramesh Chandra et al.   Frontiers in Molecular Neuroscience

Estrogen Receptors Are Found in Glia and at Extranuclear Neuronal Sites in the Dorsal Striatum of Female Rats: Evidence for Cholinergic But Not Dopaminergic Colocalization

(2012) Anne Almey et al.   ENDOCRINOLOGY

Serum Response Factor and cAMP Response Element Binding Protein Are Both Required for Cocaine Induction of  FosB

(2012) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Activation of VTA GABA Neurons Disrupts Reward Consumption

(2012) Ruud van Zessen et al.   NEURON

GABA Neurons of the VTA Drive Conditioned Place Aversion

(2012) Kelly R. Tan et al.   NEURON

Medical and Psychological Risks and Consequences of Long-Term Opioid Therapy in Women

(2012) Beth D. Darnall et al.   PAIN MEDICINE

Mapping of reinforcing and analgesic effects of the mu opioid agonist Endomorphin-1 in the ventral midbrain of the rat

(2012) Thomas C. Jhou et al.   PSYCHOPHARMACOLOGY

BDNF Is a Negative Modulator of Morphine Action

(2012) J. W. Koo et al.   SCIENCE

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

(2012) Jill B Becker et al.   Biology of Sex Differences

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Ultrastructural analysis of sex differences in nucleus accumbens synaptic connectivity

(2011) Anne Marie Wissman et al.   Brain Structure & Function

Sex Differences in Drug Disposition

(2011) Offie P. Soldin et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats

(2011) E. B. Larson et al.   JOURNAL OF NEUROSCIENCE

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

(2011) Rita Z. Goldstein et al.   NATURE REVIEWS NEUROSCIENCE

Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens

(2011) Anne Marie Wissman et al.   NEUROPHARMACOLOGY

Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and Their Responses to Drugs of Abuse

(2011) Salvatore Lecca et al.   NEUROPSYCHOPHARMACOLOGY

Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats

(2011) Deanne M. Buffalari et al.   PHYSIOLOGY & BEHAVIOR

Neuronal circuits underlying acute morphine action on dopamine neurons

(2011) M. Jalabert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle

(2011) Matthew W. Feltenstein et al.   PSYCHOPHARMACOLOGY

Nervous System Physiology Regulated by Membrane Estrogen Receptors

(2011) Paul G. Mermelstein et al.   REVIEWS IN THE NEUROSCIENCES

Functional Implications of Glutamatergic Projections to the Ventral Tegmental Area

(2011) Stefanie Geisler et al.   REVIEWS IN THE NEUROSCIENCES

The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia

(2011) Melissa L. Perreault et al.   Frontiers in Neuroanatomy

The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

(2011) Mary Kay Lobo et al.   Frontiers in Neuroanatomy

Gender and prescription opioids: Findings from the National Survey on Drug Use and Health

(2010) Sudie E. Back et al.   ADDICTIVE BEHAVIORS

Distribution of estrogen receptor beta containing cells in the brains of bacterial artificial chromosome transgenic mice

(2010) Teresa A. Milner et al.   BRAIN RESEARCH

Estrogen Regulation of Dopamine Release in the Nucleus Accumbens: Genomic-and Nongenomic-Mediated Effects

(2010) Tina L. Thompson et al.   JOURNAL OF NEUROCHEMISTRY

Oestrogen Receptors Enhance Dopamine Neurone Survival in Rat Midbrain

(2010) M. L. Johnson et al.   JOURNAL OF NEUROENDOCRINOLOGY

Opioid-Induced GABA Potentiation after Chronic Morphine Attenuates the Rewarding Effects of Opioids in the Ventral Tegmental Area

(2010) A. Madhavan et al.   JOURNAL OF NEUROSCIENCE

Synaptic Mechanism for Functional Synergism between  - and  -Opioid Receptors

(2010) Z. Zhang et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

(2010) Takatoshi Hikida et al.   NEURON

Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons

(2010) D. Grove-Strawser et al.   NEUROSCIENCE

Measurements of neuron soma size and density in rat dorsal striatum, nucleus accumbens core and nucleus accumbens shell: Differences between striatal region and brain hemisphere, but not sex

(2010) John Meitzen et al.   NEUROSCIENCE LETTERS

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

(2010) G. E. Gillies et al.   PHARMACOLOGICAL REVIEWS

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Sex-Specific Responses to Opiates: Animal and Human Studies

(2009) Albert Dahan et al.   ANESTHESIA AND ANALGESIA

Nongenomic mechanisms of physiological estrogen-mediated dopamine efflux

(2009) Rebecca A Alyea et al.   BMC NEUROSCIENCE

Women who abuse prescription opioids: Findings from the Addiction Severity Index-Multimedia Version® Connect prescription opioid database

(2009) Traci C. Green et al.   DRUG AND ALCOHOL DEPENDENCE

Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats

(2009) Justin J. Anker et al.   DRUG AND ALCOHOL DEPENDENCE

Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: Central mechanisms of action and roles of gonadal hormones

(2009) Richard J. Bodnar et al.   HORMONES AND BEHAVIOR

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta

(2009) Thomas C. Jhou et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ERα in PC12 cells

(2009) Shreekrishna Maharjan et al.   JOURNAL OF NEUROCHEMISTRY

Membrane-Localised Oestrogen Receptor α and β Influence Neuronal Activity Through Activation of Metabotropic Glutamate Receptors

(2009) P. G. Mermelstein   JOURNAL OF NEUROENDOCRINOLOGY

Nuclear Factor  B Signaling Regulates Neuronal Morphology and Cocaine Reward

(2009) S. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Viral Vector-Mediated Overexpression of Estrogen Receptor-  in Striatum Enhances the Estradiol-Induced Motor Activity in Female Rats and Estradiol-Modulated GABA Release

(2009) K. N. Schultz et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

PKA-mediated responses in females' estrous cycle affect cocaine-induced responses in dopamine-mediated intracellular cascades

(2009) J. Weiner et al.   NEUROSCIENCE

Estrogen pretreatment modulates morphine-induced conditioned place preference in ovariectomized mice

(2009) Hilda Mirbaha et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sex Differences in Drug-Related Stress-System Changes

(2009) Helen C. Fox et al.   HARVARD REVIEW OF PSYCHIATRY

Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens

(2008) Yvette C. van Dongen et al.   Brain Structure & Function

The structural basis for mapping behavior onto the ventral striatum and its subdivisions

(2008) Gloria E. Meredith et al.   Brain Structure & Function

Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

(2008) M J Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

Role of the Dopamine Transporter in the Action of Psychostimulants, Nicotine, and Other Drugs of Abuse

(2008) J. Zhu et al.   CNS & Neurological Disorders-Drug Targets

Protein Kinase C Signaling in the Hypothalamic Arcuate Nucleus Regulates Sexual Receptivity in Female Rats

(2008) Phoebe Dewing et al.   ENDOCRINOLOGY

CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis

(2008) Thomas Lemberger et al.   FASEB JOURNAL

Regulation of psychostimulant-induced signaling and gene expression in the striatum

(2008) Jacqueline F. McGinty et al.   JOURNAL OF NEUROCHEMISTRY

Region and Sex Differences in Constituent Dopamine Neurons and Immunoreactivity for Intracellular Estrogen and Androgen Receptors in Mesocortical Projections in Rats

(2008) M. F. Kritzer et al.   JOURNAL OF NEUROSCIENCE

Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

(2008) J. Bertran-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

Membrane-initiated estrogen signaling in hypothalamic neurons

(2008) Martin J. Kelly et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Membrane Estrogen Receptors Acting Through Metabotropic Glutamate Receptors: An Emerging Mechanism of Estrogen Action in Brain

(2008) Paul E. Micevych et al.   MOLECULAR NEUROBIOLOGY

Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats

(2008) K.-R. Shieh et al.   NEUROSCIENCE

The effect of exposure to drugs on the processing of natural rewards

(2008) Patrick Anselme   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inhibition of the ubiquitin–proteasome activity prevents glutamate transporter degradation and morphine tolerance

(2008) Liling Yang et al.   PAIN

The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats

(2008) Brooke A. Davis et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sensitivity to cocaine conditioned reward depends on sex and age

(2008) Elena Zakharova et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Transcriptional mechanisms of addiction: role of  FosB

(2008) E. J Nestler   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Functional alterations of the nigrostriatal dopamine system in estrogen receptor-α knockout (ERKO) mice

(2008) Eva Küppers et al.   PSYCHONEUROENDOCRINOLOGY

Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine

(2008) Die Zhang et al.   PSYCHOPHARMACOLOGY

Sex differences in basal and cocaine-induced alterations in PKA and CREB proteins in the nucleus accumbens

(2008) Arbi Nazarian et al.   PSYCHOPHARMACOLOGY

High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking

(2008) D. Belin et al.   SCIENCE

Distinct patterns of ΔFosB induction in brain by drugs of abuse

(2008) L.I. Perrotti et al.   SYNAPSE

Sex Differences in Non-Reinforced Responding for Cocaine

(2008) Therese A. Kosten et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Addiction and the Brain Antireward System

(2007) George F. Koob et al.   Annual Review of Psychology

Morphine sex-dependently induced place conditioning in adult Wistar rats

(2007) Manizheh Karami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sex differences in drug abuse

(2007) Jill B. Becker et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain

(2007) M. Morissette et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Induction of nuclear factor-κB in nucleus accumbens by chronic cocaine administration

(2003) Eugenius Ang et al.   JOURNAL OF NEUROCHEMISTRY