期刊
NEURAL PLASTICITY
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/7027949
关键词
-
资金
- Leibniz Association, Germany
- VELUX Foundation, Switzerland
Activation of nuclear factor kappa B (NF-kappa B) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-kappa B dimers move to the nucleus to translate synaptic signals into altered gene expression. Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits. Recent research on transgenic mice with impaired or hyperactivated NF-kappa B gave important insights into plasticity-related target gene expression that is regulated by NF-kappa B. In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF-kappa B in the aged and diseased brain that may directly or indirectly affect kappa B-dependent transcription of synaptic genes.
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