Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13

Pd-Catalyzed α-Selective C–H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

(2016) Wei-Jun Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists

(2015) Matteo Gianella-Borradori et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors

(2013) Marilena Tauro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Probing the S1′ Site for the Identification of Non-Zinc-Binding MMP-2 Inhibitors

(2013) Antonella Di Pizio et al.   ChemMedChem

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Matrix metalloproteinase-2 as a target for head and neck cancer therapy

(2012) Ming-Hsien Chien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Matrix metalloproteinase 2 overexpression and prognosis in colorectal cancer: a meta-analysis

(2012) Mumu Shi et al.   MOLECULAR BIOLOGY REPORTS

Fragment-based lead discovery grows up

(2012) Monya Baker   NATURE REVIEWS DRUG DISCOVERY

Novel synthesis and functionalization of ortho–ortho disubstituted biphenyls and a highly condensed novel heterocycle using radical cyclization reaction

(2012) C.H. Wang et al.   TETRAHEDRON

Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

(2011) Maria Teresa Rubino et al.   ChemMedChem

Fragmenting the S100B-p53 Interaction: Combined Virtual/Biophysical Screening Approaches to Identify Ligands

(2010) Mariangela Agamennone et al.   ChemMedChem

Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

(2010) Jennifer A. Jacobsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of N-alkylanthranilamides with a chiral substituent at the nitrogen atom

(2010) Alexander V. Kurkin et al.   TETRAHEDRON-ASYMMETRY

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis, SAR, and Biological Evaluation of α-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

(2009) Maria Teresa Rubino et al.   ChemMedChem

Synthesis of isatins with a chiral substituent at the nitrogen atom

(2009) Alexander V. Kurkin et al.   TETRAHEDRON-ASYMMETRY

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

(2008) Helena Nordström et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Versatile Synthesis of Unsymmetrical 3,3′-Bioxindoles: Stereoselective Mukaiyama Aldol Reactions of 2-Siloxyindoles with Isatins

(2008) J. Michael Ellis et al.   JOURNAL OF ORGANIC CHEMISTRY

Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors

(2007) Cristina Campestre et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY