Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?

Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51

(2016) Wei Lv et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency

(2016) Jun Song et al.   Nature Communications

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells

(2015) Jennifer M. Mason et al.   NUCLEIC ACIDS RESEARCH

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells

(2015) Hongyu Ma et al.   Radiation Oncology

The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma

(2015) Ken Maes et al.   Oncotarget

Identification and characterization of human Rad51 inhibitors by screening of an existing drug library

(2014) Anaïs Normand et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the homologous recombination pathway by small molecule modulators

(2014) Fei Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The RAD51-Stimulatory Compound RS-1 Can Exploit the RAD51 Overexpression That Exists in Cancer Cells and Tumors

(2014) J. M. Mason et al.   CANCER RESEARCH

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

(2014) Fei Huang et al.   PLoS One

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

(2014) David A. Alagpulinsa et al.   Frontiers in Oncology

Attenuating homologous recombination stimulates an AID-induced antileukemic effect

(2013) Kristin R. Lamont et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing

(2013) Brian Budke et al.   NUCLEIC ACIDS RESEARCH

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

An Optimized RAD51 Inhibitor That Disrupts Homologous Recombination without Requiring Michael Acceptor Reactivity

(2012) Brian Budke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase

(2012) Fei Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

(2012) Brian Budke et al.   NUCLEIC ACIDS RESEARCH

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51

(2011) Motoki Takaku et al.   GENES TO CELLS

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Swi2/Snf2-Related Translocases Prevent Accumulation of Toxic Rad51 Complexes during Mitotic Growth

(2010) Parisha P. Shah et al.   MOLECULAR CELL

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor

(2009) Yang Li et al.   BIOCHEMISTRY

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange

(2009) Takako Ishida et al.   NUCLEIC ACIDS RESEARCH

The consequences of Rad51 overexpression for normal and tumor cells

(2008) Hannah L. Klein   DNA REPAIR

RAD54 controls access to the invading 3′-OH end after RAD51-mediated DNA strand invasion in homologous recombination in Saccharomyces cerevisiae

(2008) Xuan Li et al.   NUCLEIC ACIDS RESEARCH

A chemical compound that stimulates the human homologous recombination protein RAD51

(2008) K. Jayathilaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of the Rad51 promoter for targeted anti-cancer therapy

(2008) C. M. Hine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics