Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system

(2019) Chon Lok Lei et al.   BIOPHYSICAL JOURNAL

Rapid characterisation of hERG channel kinetics II: temperature dependence

(2019) Chon Lok Lei et al.   BIOPHYSICAL JOURNAL

An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

(2018) Alison Obergrussberger et al.   Expert Opinion on Drug Discovery

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

(2018) Kylie A. Beattie et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction

(2018) Monique J. Windley et al.   MOLECULAR PHARMACOLOGY

Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential

(2018) Péter Orvos et al.   TOXICOLOGICAL SCIENCES

An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data

(2017) Christopher E. Pollard et al.   TOXICOLOGICAL SCIENCES

An “All Inclusive “Package for Cardiac Safety: The Six Big on One Automated Patch Clamp Chip

(2017) Corina Bot et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment

(2017) Kelly C. Chang et al.   Frontiers in Physiology

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

(2017) Sara Dutta et al.   Frontiers in Physiology

Predicting drug-induced QT prolongation and torsades de pointes

(2016) Dan M. Roden   JOURNAL OF PHYSIOLOGY-LONDON

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Novel screening techniques for ion channel targeting drugs

(2015) Alison Obergrussberger et al.   Channels

Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves

(2014) Shawn C. Owen et al.   ACS Chemical Biology

Early identification of hERG liability in drug discovery programs by automated patch clamp

(2014) Timm Danker et al.   Frontiers in Pharmacology

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

(2013) GIOVANNI Y. DI VEROLI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors

(2013) Maria F. Sassano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

(2013) Ryan C. Elkins et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

HTS techniques for patch clamp-based ion channel screening – advances and economy

(2012) Cecilia Farre et al.   Expert Opinion on Drug Discovery

hERG potency estimates based upon dose solution analysis: What have we learned?

(2011) Yusheng Qu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Integrated risk assessment and predictive value to humans of non-clinical repolarization assays

(2009) Robert M Wallis   BRITISH JOURNAL OF PHARMACOLOGY