期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 11, 期 5, 页码 750-756出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201501216
关键词
conjugate materials; hemoglobin; metal-organic frameworks; nanoparticles; oxygen carriers
资金
- National Natural Science Foundation of China [21401188, 51522307, 91227118]
A metal-organic framework (MOF)-protein conjugate, NH2-MIL-125(Ti)-hemoglobin [MIL-125(Ti)-Hb], was synthesized by a covalent postmodification strategy. The crystalline structure was maintained after chemical and protein modification. The content of grafted Hb was tuned by the stoichiometric ratio and reached 50wt% if the mass ratio of MIL-125(Ti)/Hb was 1:1.25 in the feed. The oxygen-transporting capacity of grafted Hb was kept, and the P-50 (the half O-2 pressure saturated with O-2) and Hill coefficients of the MIL-125(Ti)-Hb conjugate were found to be 22.9mmHg and 2.35, respectively, which are close to the respective values of free Hb. All the results indicate that the MIL-125(Ti)-Hb conjugate could be potentially used as an oxygen carrier.
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