Article
Engineering, Manufacturing
Mecit Altan Alioglu, Yogendra Pratap Singh, Momoka Nagamine, Syed Hasan Askari Rizvi, Vaibhav Pal, Ethan Michael Gerhard, Shweta Saini, Myoung Hwan Kim, Ibrahim T. Ozbolat
Summary: Over the past two decades, microfluidic devices have become revolutionary platforms in research and medicine. Existing fabrication strategies face challenges in recreating complex structural organizations. In this study, a silicone composite was developed and used as a support bath for 3D printing sacrificial ink, enabling the fabrication of complex-shaped microfluidic devices. The strategy allows for facile, rapid, cost-effective, and high-resolution printing, with potential applications in organ-on-a-chip devices, 3D bioprinting, and drug testing.
ADDITIVE MANUFACTURING
(2023)
Article
Chemistry, Multidisciplinary
Clement Achille, Cesar Parra-Cabrera, Ruben Dochy, Henry Ordutowski, Agnese Piovesan, Pieter Piron, Lore Van Looy, Shashwat Kushwaha, Dominiek Reynaerts, Pieter Verboven, Bart Nicolai, Jeroen Lammertyn, Dragana Spasic, Rob Ameloot
Summary: Rapid diagnostic testing at the site of the patient is essential when a fully equipped laboratory is not accessible. 3D-printed microfluidic devices offer a scalable route to low-cost diagnostics and eliminate the need for assembly of discrete components. The seamless transition between digital data and physical objects allows for rapid design iterations and opens up perspectives on distributed manufacturing.
ADVANCED MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Benzion Amoyav, Yoel Goldstein, Eliana Steinberg, Ofra Benny
Summary: Microfluidics research has shown exponential growth in various applications, with the combination of 3D printing technology providing an efficient platform for particle production, reducing costs and time. The one-step fabrication process for a microfluidic chip for drug dissolution assays has advantages in terms of encapsulation efficiency and drug content compared to traditional batch formulations.
Review
Engineering, Manufacturing
Gustavo Gonzalez, Ignazio Roppolo, Candido Fabrizio Pirri, Annalisa Chiappone
Summary: In the past two decades, 3D printing technology has emerged as an alternative for producing microfluidic devices, making their production cheaper, faster, and easier. However, there are still barriers to overcome in terms of technology and materials. This review evaluates the current state of polymeric 3D printing techniques and materials for manufacturing microfluidic chips, highlighting the latest innovations, materials, and applications.
ADDITIVE MANUFACTURING
(2022)
Article
Nanoscience & Nanotechnology
Niclas Weigel, Max J. Maennel, Julian Thiele
Summary: The study focuses on developing resins for high-resolution additive manufacturing of flexible micromaterials through projection micro-stereolithography (P mu SL). The best-candidate resin allows for 3D-printing transparent microchannels with a minimum cross section and exhibits proper solvent resistance. The mechanical properties are suitable for 3D-printing microfluidic devices with integrated functional units, expanding the library of functional resins for P mu SL printing towards flexible materials with micrometer resolution.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yipu Du, Julius Reitemeier, Qiang Jiang, Md Omarsany Bappy, Paul W. Bohn, Yanliang Zhang
Summary: A multi-materials multi-scale hybrid printing method is introduced for the rapid fabrication of complex microfluidic devices. A fully printed, assembly-free biosensor for amperometric lactate detection in sweat is demonstrated, featuring sub-100 μm fluidic channels and functionalized electrodes. The sensor exhibits a sensitive response, and the technique opens up new possibilities for point-of-care health monitoring.
Article
Engineering, Chemical
Jia Zhang, Wenhua Xu, Fengying Xu, Wangwang Lu, Liuyun Hu, Jianlin Zhou, Chen Zhang, Zhuo Jiang
Summary: Droplet microfluidics using 3D printing technology to fabricate microfluidic devices show great potential in food emulsion processing, enabling efficient generation of single emulsions and double emulsions with stability and high quality.
JOURNAL OF FOOD ENGINEERING
(2021)
Review
Chemistry, Analytical
Lujun Wang, Martin Pumera
Summary: 3D printing has been widely used in microfluidic devices, separation sciences, and sample extraction, with great potential for on-demand fabrication of separation tools with the development of new materials.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Ander Switalla, Lael Wentland, Elain Fu
Summary: Fabric-based microfluidics is a growing sub-field of porous materials-based microfluidics. In this report, a straightforward method for 3D printing fabric-based microfluidic devices is described. The ability to create barriers in fabric is demonstrated, and the method is characterized for minimum channel and barrier widths, as well as flow time repeatability. Considerations specific to 3D printing in fabric are discussed, and the fabrication method is highlighted through the implementation of a colorimetric urea assay.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Anatolii Makhinia, Pooya Azizian, Valerio Beni, Jasmina Casals-Terre, Joan M. Cabot, Peter Andersson Ersman
Summary: Microfluidic surface chemistry allows for control of capillary-driven flow without bulky external instrumentation. A novel nonhomogeneous coating is used to define regions with different wetting properties on microchannel walls, leading to different capillary pressures and automatic flow control. This method employs inkjet printing to deposit hydrophilic coatings on the surfaces of 3D-printed microfluidic devices, enabling capillary flow control in 3D-printed microfluidics for the first time. The method is further utilized to create stop and delay valves and integrated with organic electrochemical transistors for sensing applications.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Federica Sommonte, Edward Weaver, Essyrose Mathew, Nunzio Denora, Dimitrios A. A. Lamprou
Summary: Nanotechnology applications, specifically nanoparticulate lipidic systems and liposomes, have become a highly researched field in recent years, offering promising prospects in the pharmaceutical industry. This study successfully combined microfluidic technology with 3D printing to create diamond-shaped devices for producing liposomes loaded with the model drug lysozyme. The resulting liposomes demonstrated stability and efficient drug encapsulation, with a high release percentage observed within a 72-hour period.
Article
Polymer Science
Francesc Subirada, Roberto Paoli, Jessica Sierra-Agudelo, Anna Lagunas, Romen Rodriguez-Trujillo, Josep Samitier
Summary: The combination of microfluidics and stereolithography (SLA) has great potential in areas like biological analysis and chemical detection. In this article, microfluidic devices were manufactured using different methods, and significant results were achieved for 3D printing with commercial resins.
Article
Chemistry, Analytical
Mawla Boaks, Connor Roper, Matthew Viglione, Kent Hooper, Adam T. Woolley, Kenneth A. Christensen, Gregory P. Nordin
Summary: We demonstrate the effective 3D printing of high-resolution microfluidic devices using a biocompatible resin based on avobenzone as the UV absorber. We achieve high out-of-plane resolution by spectrally shaping the 3D printer source spectrum to overlap completely with the absorption spectrum of avobenzone. Furthermore, we show reliable membrane valves and pumps using the biocompatible resin, and successfully create concentration gradient generation components for cell chemotaxis studies.
Article
Biochemistry & Molecular Biology
Giulia Ballacchino, Edward Weaver, Essyrose Mathew, Rossella Dorati, Ida Genta, Bice Conti, Dimitrios A. Lamprou
Summary: Microfluidic technique is a promising tool for producing stable and monodispersed nanoparticles, with a focus on liposome production in this study. The use of 3D printing for microfluidic device production has provided a revolutionary, low-cost option. The study evaluated the impact of microfluidic parameters, chip manufacturing, material, and channel design on liposomal characteristics, and demonstrated enhanced encapsulation efficiency of curcumin-loaded liposomes produced by microfluidics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Mechanical
Mojtaba Zeraatkar, Marco Donato de Tullio, Alessio Pricci, Francesco Pignatelli, Gianluca Percoco
Summary: This study introduces an alternative construction for microfluidic micromixers using the effect of extruded filaments in FDM technique. Experimental and numerical studies showed that the geometrical features on microchannels can act as ridges and enhance chaotic mixing through transverse movement of fluids. Compared to other methods, FDM offers a simpler fabrication process with inherent properties that enhance mixing processes.
RAPID PROTOTYPING JOURNAL
(2021)
Review
Immunology
Habib Sadeghirad, Tayyeb Bahrami, Sepideh M. Layeghi, Hassan Yousefi, Meysam Rezaei, Seyed R. Hosseini-Fard, Payar Radfar, Majid E. Warkiani, Ken O'Byrne, Arutha Kulasinghe
Summary: This review discusses the immunotherapeutic targets in non-small cell lung cancer (NSCLC) tumors and how the tumor microenvironment (TME) can influence the response to immunotherapy.
Review
Environmental Sciences
Asieh Soozanipour, Fatemeh Ejeian, Yasaman Boroumand, Azam Rezayat, Sina Moradi
Summary: The growing pace of urbanization, new lifestyles, climate changes, and resource exploitation significantly affect global health status. Modern technologies, particularly in the field of biotechnology, have provided promising solutions for sustainable development in water, food, and medicine. Novel organic/inorganic materials and bioinspired materials have greatly improved traditional systems in water treatment, anti-fouling, anti-microbial agents, food processing, biosensors, drug delivery systems, and implants. Additionally, the development of innovative devices for monitoring and managing ecosystem and human health issues, such as ion-selective electrodes (ISEs), micro-electromechanical systems (MEMs), and implantable medical devices, has greatly impacted environmental and biomedical research.
Article
Materials Science, Multidisciplinary
Sajad Razavi Bazaz, Sareh Zhand, Robert Salomon, Elham Hosseini Beheshti, Dayong Jin, Majid Ebrahimi Warkiani
Summary: This study used the ImmunoInertial microfluidics approach to isolate specific subpopulations of cancer-specific small extracellular vesicles (sEVs), demonstrating high efficiency and selectivity. The method has the advantages of high sensitivity, low cost, and ability to process samples of varying volumes, making it a promising strategy for cancer diagnosis and prognosis in liquid biopsies.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Multidisciplinary
Huilin Zhang, Yang Chen, Wei Hua, Wenjun Gu, Hongjun Zhuang, Huiyan Li, Xingwu Jiang, Ying Mao, Yanyan Liu, Dayong Jin, Wenbo Bu
Summary: A built-in electric field (BIEF)-driven strategy was proposed for sustainable generation of hydroxyl radicals ((OH)-O-center dot) for long-lasting chemodynamic therapy. A novel Fe@Fe3O4-Cu2O heterogeneous catalyst was designed, allowing continuous Fenton-like reactions and (OH)-O-center dot release for over 18 hours. The sustained (OH)-O-center dot levels led to persistent activation of extracellular regulated protein kinases (ERK) signal and irreversible oxidative damage, resulting in tumor apoptosis. This strategy provides ideas for developing long-acting nanoplatforms for various applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sahar Masoumeh Ghorbanpour, Shihui Wen, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan, Dayong Jin, Lana McClements
Summary: In this study, a novel strip-based lateral flow assay (LFA) using lanthanide-doped upconversion nanoparticles conjugated to antibodies was developed for detecting preeclampsia. The CD44/FKBPL ratio was found to be reduced in early-onset preeclampsia (EOPE) with good diagnostic potential. The improved LFA prototypes achieved a lower limit of detection for FKBPL and CD44, making it more sensitive than the standard ELISA method. The LFA showed promise as a rapid and highly sensitive point-of-care test for preeclampsia, with a 100% positive predictive value and 91% negative predictive value using clinical samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Lin Zhang, Cheng Cao, Szun S. Tay, Chaohao Chen, Alexander Macmillan, Shihui Wen, Dayong Jin, Joshua McCarroll, Martina H. Stenzel
Summary: Polymer-coated inorganic nanoparticles have unique magnetic, optical, and thermal properties that make them promising drug delivery systems. However, the biological behavior of these nanoparticles is affected by various factors such as size, shape, and protein corona. This study focuses on the effect of drug loading amount on the biological activity of inorganic nanoparticles and highlights the importance of optimizing drug loading amounts in order to achieve optimal drug delivery.
CHEMISTRY OF MATERIALS
(2023)
Article
Engineering, Chemical
Huan Xiao, Milton Chai, Amin Hosseini, Asghar Habibnejad Korayem, Mojtaba Abdollahzadeh, Hadi Ahmadi, Vicki Chen, Damian B. Gore, Mohsen Asadnia, Amir Razmjou
Summary: Membrane technology plays a crucial role in environmental and energy applications. This study focuses on the development of a metal-organic framework (MOF) membrane with smart ion permeability and selectivity, achieved through post-synthetic modification. The ion-selective performance of the MOF-based membrane is influenced by the ionic environments and can be modulated by specific ion activation.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Mahtab Firoozi, Mehdi Entezam, Fatemeh Ejeian, Elahe Masaeli
Summary: In the field of regenerative medicine, researchers are investigating using ECM-inspired materials to imitate mechanotransduction pathways and control cell fate. In musculoskeletal tissue regeneration, biocompatible and viscoelastic biomaterials that can retain water content are needed to enhance mechano-biological signals. Therefore, PVA-based composite hydrogels reinforced with PHB nanofibers are proposed to differentiate equine adipose-derived stem cells for musculoskeletal regeneration. Different fiber assembly methods have been studied to investigate their effects on scaffold properties.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Sheyda Mirjalali, Roohollah Bagherzadeh, Shayan Abrishami, Mohsen Asadnia, Shujuan Huang, Aron Michael, Shuhua Peng, Chun-Hui Wang, Shuying Wu
Summary: A new method of enhancing the piezoelectricity of PVDF nanofiber mats by electrospraying zinc oxide (ZnO) nanoparticles between layers of PVDF nanofibers is demonstrated. This approach results in multilayered PVDF+ZnO nanofiber mats with significantly increased piezoelectricity.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yongtao Liu, Shihui Wen, Fan Wang, Chao Zuo, Chaohao Chen, Jiajia Zhou, Dayong Jin
Summary: Upconverting stimulated emission depletion microscopy (U-STED) is an effective approach for super-resolution imaging due to its low depletion power and ability to overcome the limitations of the square-root law. However, there is a trade-off between spatial resolution and imaging quality in U-STED, and finding the ideal excitation power is challenging. This study proposes a method to predict the ideal excitation power using non-saturate excitation based on the dynamic cross-relaxation energy transfer of upconversion nanoparticles, allowing for high depletion efficiency and resolution under 40 nm.
Correction
Chemistry, Analytical
Sareh Zhand, Ying Zhu, Hojjatollah Nazari, Mohammad Sadraeian, Majid Ebrahimi Warkiani, Dayong Jin
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Hojjatollah Nazari, Jesus Shrestha, Vahid Yaghoubi Naei, Sajad Razavi Bazaz, Milad Sabbagh, Jean Paul Thiery, Majid Ebrahimi Warkiani
Summary: Biological barriers are multicellular structures that regulate the transport of various substances. Transendothelial/epithelial electrical resistance (TEER) is a label-free method used to predict barrier properties. Integrating TEER measurement with organ-on-a-chip technology provides valuable insight into barrier behavior and enhances TEER measurement accuracy. This review discusses the applications, advantages, and future perspectives of integrating organ-on-a-chip technology with TEER measurement methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Seyed Javad Mousavi, Fatemeh Ejeian, Amir Razmjou, Mohammad Hossein Nasr-Esfahani
Summary: This study demonstrates the potential of ZIF8 thin film for inducing bone regeneration, and supports its clinical application. The ZIF8-coated membrane outperforms the PP membrane in terms of mechanical properties, barrier function, and bone tissue repair.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Editorial Material
Optics
Zhichao Yang, Dayong Jin
Summary: Precise orthogonal polarization control has been achieved by leveraging the resonant modes of all-dielectric metasurfaces, specifically quasi-bound state in the continuum and Mie resonances.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Analytical
Arslan Kiyani, Mohsen Asadnia, Syed Muzahir Abbas, Karu P. Esselle, Abdelhady Mahmoud
Summary: This article introduces an application of a grounded substrate-based metasurface for hosting dielectric resonators (DRs) to achieve a wide dual-band circularly polarized (CP) operation. The design utilizes a rectangular DR structure and a square-slotted metasurface positioned above a grounded substrate. By adjusting the feed angle and ensuring good matching with the metasurface, the antenna achieves significant performance improvement, including an 88.1% impedance bandwidth and overlapping 3-dB axial ratio bandwidths.