Generation of intestinal organoids derived from human pluripotent stem cells for drug testing

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids

(2018) Yu Takahashi et al.   Stem Cell Reports

Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

(2017) Kentaro Kitano et al.   Nature Communications

Functional Enterospheres Derived In Vitro from Human Pluripotent Stem Cells

(2017) Rohan R. Nadkarni et al.   Stem Cell Reports

Application of a Human Intestinal Epithelial Cell Monolayer to the Prediction of Oral Drug Absorption in Humans as a Superior Alternative to the Caco-2 Cell Monolayer

(2016) Toru Takenaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

(2015) Tatsuya Ozawa et al.   Scientific Reports

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

(2015) Stacy R. Finkbeiner et al.   Stem Cell Reports

How to make an intestine

(2014) J. M. Wells et al.   DEVELOPMENT

Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

(2014) Akihiro Yamashita et al.   NATURE

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

(2014) Kazuo Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells

(2013) Scott T. Magness et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Wnt and Notch Signals Guide Embryonic Stem Cell Differentiation into the Intestinal Lineages

(2013) Soichiro Ogaki et al.   STEM CELLS

EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins

(2012) Zili Lei et al.   DEVELOPMENTAL BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes

(2011) J. Harper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

Comparison of Drug Permeabilities and BCS Classification: Three Lipid-Component PAMPA System Method versus Caco-2 Monolayers

(2010) Zeynep S. Teksin et al.   AAPS Journal

Transient activation ofc-MYCexpression is critical for efficient platelet generation from human induced pluripotent stem cells

(2010) Naoya Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Towards Prediction of In Vivo Intestinal Absorption Using a 96-Well Caco-2 Assay

(2010) Suzanne Skolnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A Novel Design of Artificial Membrane for Improving the PAMPA Model

(2008) Xiaoxi Chen et al.   PHARMACEUTICAL RESEARCH