Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

(2011) Mohammed Bourdi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3

(2011) Amir A. Ghaffari et al.   HEPATOLOGY

Enhanced Infection of Liver Sinusoidal Endothelial Cells in a Mouse Model of Antibody-Induced Severe Dengue Disease

(2010) Raphaël M. Zellweger et al.   Cell Host & Microbe

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

Toll-like receptors as targets in chronic liver diseases

(2009) A Mencin et al.   GUT

Type I interferon drives tumor necrosis factor–induced lethal shock

(2009) Liesbeth Huys et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice

(2008) Bin Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Deleterious Role of TLR3 during Hyperoxia-induced Acute Lung Injury

(2008) Lynne A. Murray et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE