Understanding Amyloid-β Oligomerization at the Molecular Level: The Role of the Fibril Surface

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

(2016) Georg Meisl et al.   Scientific Reports

An Early Folding Contact between Phe19 and Leu34 is Critical for Amyloid-β Oligomer Toxicity

(2015) Anand K. Das et al.   ACS Chemical Neuroscience

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils

(2014) Christofer Lendel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of Amyloid-β Fibril Elongation

(2014) Thomas Gurry et al.   BIOCHEMISTRY

Early amyloid β-protein aggregation precedes conformational change

(2014) Bogdan Barz et al.   CHEMICAL COMMUNICATIONS

Fibril Elongation by Aβ17–42: Kinetic Network Analysis of Hybrid-Resolution Molecular Dynamics Simulations

(2014) Wei Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation

(2013) Jae Sun Jeong et al.   JOURNAL OF MOLECULAR BIOLOGY

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Kinetic pathways to peptide aggregation on surfaces: The effects of β-sheet propensity and surface attraction

(2012) Alex Morriss-Andrews et al.   JOURNAL OF CHEMICAL PHYSICS

A Mobile Precursor Determines Amyloid-β Peptide Fibril Formation at Interfaces

(2012) Lei Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study

(2012) Bogdan Barz et al.   PLoS One

Recent progress in understanding Alzheimer's β-amyloid structures

(2011) Marcus Fändrich et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35

(2011) Jessica Nasica-Labouze et al.   PLoS Computational Biology

Elucidation of Amyloid β-Protein Oligomerization Mechanisms: Discrete Molecular Dynamics Study

(2010) B. Urbanc et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of β-sheet self-organization at water-hydrophobic interfaces

(2010) Ana Nikolic et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Replica Exchange Simulations of the Thermodynamics of A β Fibril Growth

(2009) Takako Takeda et al.   BIOPHYSICAL JOURNAL

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE