Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
出版年份 2020 全文链接
标题
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-05-20
DOI
10.1038/s41467-020-16399-y
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting Huntingtin Expression in Patients with Huntington’s Disease
- (2019) Sarah J. Tabrizi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic and Functional Approaches to Understanding Cancer Aneuploidy
- (2018) Alison M. Taylor et al. CANCER CELL
- A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment
- (2018) Xiao Zhao et al. CANCER LETTERS
- Comprehensive Characterization of Cancer Driver Genes and Mutations
- (2018) Matthew H. Bailey et al. CELL
- Structure-based design of targeted covalent inhibitors
- (2018) Richard Lonsdale et al. CHEMICAL SOCIETY REVIEWS
- Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells
- (2018) Atilgan Yilmaz et al. NATURE CELL BIOLOGY
- Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer
- (2018) Srinivas R. Viswanathan et al. NATURE GENETICS
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
- (2018) Hong-Xia Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- Engineered CRISPR-Cas9 nuclease with expanded targeting space
- (2018) Hiroshi Nishimasu et al. SCIENCE
- Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
- (2018) James M. McFarland et al. Nature Communications
- Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
- (2017) Prasenjit Dey et al. NATURE
- RNA targeting with CRISPR–Cas13
- (2017) Omar O. Abudayyeh et al. NATURE
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- Tracking the Evolution of Non–Small-Cell Lung Cancer
- (2017) Mariam Jamal-Hanjani et al. NEW ENGLAND JOURNAL OF MEDICINE
- In situ click chemistry generation of cyclooxygenase-2 inhibitors
- (2017) Atul Bhardwaj et al. Nature Communications
- Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
- (2017) Brenton R Paolella et al. eLife
- Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
- (2017) Michiru Nishita et al. Scientific Reports
- Small-Molecule PROTACS: New Approaches to Protein Degradation
- (2016) Momar Toure et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Analysis of protein-coding genetic variation in 60,706 humans
- (2016) Monkol Lek et al. NATURE
- Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
- (2016) Christopher D Richardson et al. NATURE BIOTECHNOLOGY
- The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis
- (2016) William J Gibson et al. NATURE GENETICS
- The regulation and functions of the nuclear RNA exosome complex
- (2016) Cornelia Kilchert et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
- (2015) Wujin Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability
- (2015) Gaowen Liu et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
- (2015) T.-M. Kim et al. CLINICAL CANCER RESEARCH
- CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting
- (2015) D G Courtney et al. GENE THERAPY
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- canSAR: an updated cancer research and drug discovery knowledgebase
- (2015) Joseph E. Tym et al. NUCLEIC ACIDS RESEARCH
- Identification and characterization of essential genes in the human genome
- (2015) T. Wang et al. SCIENCE
- Combinatorially Designed Lipid-like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy
- (2014) Ming Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles
- (2014) Bülent Arman Aksoy et al. BIOINFORMATICS
- Clonal evolution in breast cancer revealed by single nucleus genome sequencing
- (2014) Yong Wang et al. NATURE
- ARID1B is a specific vulnerability in ARID1A-mutant cancers
- (2014) Katherine C Helming et al. NATURE MEDICINE
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Applying Synthetic Lethality for the Selective Targeting of Cancer
- (2014) Donal P. McLornan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase
- (2013) Sivaraja Vaithiyalingam et al. JOURNAL OF MOLECULAR BIOLOGY
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- RNA-guided editing of bacterial genomes using CRISPR-Cas systems
- (2013) Wenyan Jiang et al. NATURE BIOTECHNOLOGY
- Pan-cancer patterns of somatic copy number alteration
- (2013) Travis I Zack et al. NATURE GENETICS
- Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
- (2013) Z. Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Cancer Vulnerabilities Unveiled by Genomic Loss
- (2012) Deepak Nijhawan et al. CELL
- Systemic Delivery of Modified mRNA Encoding Herpes Simplex Virus 1 Thymidine Kinase for Targeted Cancer Gene Therapy
- (2012) Yuhua Wang et al. MOLECULAR THERAPY
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Absolute quantification of somatic DNA alterations in human cancer
- (2012) Scott L Carter et al. NATURE BIOTECHNOLOGY
- canSAR: an integrated cancer public translational research and drug discovery resource
- (2011) Mark D. Halling-Brown et al. NUCLEIC ACIDS RESEARCH
- Synthetic lethality: General principles, utility and detection using genetic screens in human cells
- (2010) Sebastian M.B. Nijman FEBS LETTERS
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A
- (2009) O R F Mook et al. CANCER GENE THERAPY
- Short motif sequences determine the targets of the prokaryotic CRISPR defence system
- (2009) MICROBIOLOGY-SGM
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
- (2009) Andrew J. Holland et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- The exosome: a multipurpose RNA-decay machine
- (2008) Manfred Schmid et al. TRENDS IN BIOCHEMICAL SCIENCES
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