MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity

Role of neurons in the control of immune defense

(2019) Casandra Hoffman et al.   CURRENT OPINION IN IMMUNOLOGY

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α–Driven Keratinocyte Inflammation

(2018) Laura Israël et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

(2018) James D. Phelan et al.   NATURE

Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions

(2018) Jens Staal et al.   Frontiers in Immunology

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

(2017) Changchun Chen et al.   NATURE

Reversing behavioural abnormalities in mice exposed to maternal inflammation

(2017) Yeong Shin Yim et al.   NATURE

Neural regulation of immunity: molecular mechanisms and clinical translation

(2017) Valentin A Pavlov et al.   NATURE NEUROSCIENCE

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

IL-17 Signaling: The Yin and the Yang

(2017) Nilesh Amatya et al.   TRENDS IN IMMUNOLOGY

Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis

(2017) Matthias Ebbinghaus et al.   Scientific Reports

Modulation of neuronal excitability by immune mediators in epilepsy

(2016) Valentina Iori et al.   CURRENT OPINION IN PHARMACOLOGY

Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

(2016) Murat Artan et al.   GENES & DEVELOPMENT

g:Profiler—a web server for functional interpretation of gene lists (2016 update)

(2016) Jüri Reimand et al.   NUCLEIC ACIDS RESEARCH

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

MALT1 is not alone after all: identification of novel paracaspases

(2015) Paco Hulpiau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

Environmental CO2inhibitsCaenorhabditis elegansegg-laying by modulating olfactory neurons and evokes widespread changes in neural activity

(2015) Lorenz A. Fenk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding a neural circuit controlling global animal state in C. elegans

(2015) Patrick Laurent et al.   eLife

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

Extensive Oscillatory Gene Expression during C. elegans Larval Development

(2014) Gert-Jan Hendriks et al.   MOLECULAR CELL

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination

(2013) Changchun Chen et al.   NUCLEIC ACIDS RESEARCH

Monoubiquitination and Activity of the Paracaspase MALT1 Requires Glutamate 549 in the Dimerization Interface

(2013) Katrin Cabalzar et al.   PLoS One

Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway

(2013) Akitoshi Inoue et al.   Cell Reports

Serotonergic Chemosensory Neurons Modify the C. elegans Immune Response by Regulating G-Protein Signaling in Epithelial Cells

(2013) Alexandra Anderson et al.   PLoS Pathogens

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Mechanism and specificity of the human paracaspase MALT1

(2012) Janna Hachmann et al.   BIOCHEMICAL JOURNAL

CloudMap: A Cloud-Based Pipeline for Analysis of Mutant Genome Sequences

(2012) Gregory Minevich et al.   GENETICS

Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia

(2012) Gisela Segond von Banchet et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Evolution of Vertebrate Immunity: Sequence and Functional Analysis of the SEFIR Domain Family Member Act1

(2011) Grigory Ryzhakov et al.   JOURNAL OF MOLECULAR EVOLUTION

OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research

(2011) Jae-Seong Yang et al.   PLoS One

Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes

(2011) J. Sun et al.   SCIENCE

Role of spectral counting in quantitative proteomics

(2010) Deborah H Lundgren et al.   Expert Review of Proteomics

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans

(2009) Robert P. Shivers et al.   Cell Host & Microbe

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans

(2009) Evan Z. Macosko et al.   NATURE

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

(2009) Annelie Persson et al.   NATURE

Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis

(2009) Olivier Zugasti et al.   NATURE IMMUNOLOGY

Immune Proteins in Brain Development and Synaptic Plasticity

(2009) Lisa M. Boulanger   NEURON

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

A Polymorphism in npr-1 Is a Behavioral Determinant of Pathogen Susceptibility in C. elegans

(2009) K. C. Reddy et al.   SCIENCE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling

(2008) Trupti Kawli et al.   NATURE IMMUNOLOGY

Innate Immunity in Caenorhabditis elegans Is Regulated by Neurons Expressing NPR-1/GPCR

(2008) K. L. Styer et al.   SCIENCE