METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling

(2019) Ruifan Wu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice

(2018) Markus Heine et al.   Cell Metabolism

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

(2018) Masatoshi Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Modification of N6-methyladenosine RNA methylation on heat shock protein expression

(2018) Jiayao Yu et al.   PLoS One

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection

(2018) Charles R. Hesser et al.   PLoS Pathogens

Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication

(2018) Kevin Tsai et al.   PLoS Pathogens

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury

(2017) Xiaomeng Ren et al.   FASEB JOURNAL

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

N 6 -methyladenosine is required for the hypoxic stabilization of specific mRNAs

(2017) Nate J. Fry et al.   RNA

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo

(2017) Li Li et al.   Molecular Metabolism

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

(2016) Ruifan Wu et al.   MOLECULAR BIOTECHNOLOGY

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Methyltransferases modulate RNA stability in embryonic stem cells

(2014) Shuibin Lin et al.   NATURE CELL BIOLOGY

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

(2013) D. Tews et al.   ENDOCRINOLOGY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The YTH Domain Is a Novel RNA Binding Domain

(2010) Zhaiyi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

New developments in adipogenesis

(2009) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE