Article
Engineering, Environmental
Spencer R. Moller, Adam F. Wallace, Rumana Zahir, Abrar Quadery, Deb P. Jaisi
Summary: This research investigates the degradation of glyphosate and finds temperature-dependent preferences for the reaction pathways. Glycine pathway becomes more preferred as reaction time and temperature increase. The findings suggest possible ways to bias glyphosate degradation towards safer products and reducing overall environmental toxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Analytical
Malek Sadatsharifi, Daniel W. Ingersoll, Mihaly Purgel
Summary: This study investigates the degradation of glyphosate and its products' impact on the environment and human body, finding different reaction mechanisms and rate constants through calculations. The research reveals the significant influence of radical concentration and pH on the reaction process.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2021)
Article
Public, Environmental & Occupational Health
Rachel M. Lucia, Xiyue Liao, Wei-Lin Huang, Danielle Forman, Alexis Kim, Argyrios Ziogas, Trina M. Norden-Krichmar, Deborah Goodman, Andrea Alvarez, Irene Masunaka, Khyatiben Pathak, Marissa McGilvrey, Apurva M. Hegde, Patrick Pirrotte, Hannah Lui Park
Summary: Animal and epidemiologic studies suggest that exposure to glyphosate and its metabolite AMPA may have adverse health effects. Our study examined glyphosate and AMPA levels in the urine of postmenopausal women in Southern California and found that the majority of subjects had detectable levels. Frequent consumption of organic food was associated with lower glyphosate and AMPA levels, but this association was not significant after adjusting for other factors. Grain consumption was associated with higher glyphosate levels, even among those who reported frequently consuming organic grains. Soy protein and alcohol consumption, as well as high frequency of fast food consumption, were associated with higher AMPA levels.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Engineering, Environmental
R. Choumane, S. Peulon
Summary: This study presents a simple treatment using nanostructured lead oxides thin films to degrade glyphosate until total mineralisation with no production of its main by-product AMPA. The synthesis conditions of these materials were determined previously in relation to an electrochemical depollution process of water polluted by soluble lead. The Pb-04 sample type with cubic needles nanostructures seems particularly efficient in achieving total mineralisation with a mineralisation capacity of (1127±56) mg of glyphosate/g of material.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Environmental Sciences
Marisa A. Wirth, Lars Longwitz, Marion Kanwischer, Peter Gros, Peter Leinweber, Thomas Werner
Summary: Stable isotope labeling of pollutants is important for studying their environmental fate. A synthetic pathway to the labeled metabolite AMPA-N-15 was developed for the commonly used herbicide glyphosate, enabling its accurate detection and quantitation in soil extracts. The newly developed analysis concepts will facilitate future research on the environmental behavior of glyphosate.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Analytical
Gauthier Emonds-Alt, Cedric Malherbe, Alice Kasemiire, Hermane T. Avohou, Philippe Hubert, Eric Ziemons, Jean-Christophe M. Monbaliu, Gauthier Eppe
Summary: In this study, a method based on surface enhanced Raman spectroscopy and microfluidic system was developed for the detection of glyphosate and its main breakdown product, AMPA, in tap water. The method showed rapid, sensitive, and automated features and was validated in the experiment.
Article
Environmental Sciences
Benedikt Wimmer, Adrian Langarica-Fuentes, Erik Schwarz, Sara Kleindienst, Carolin Huhn, Holger Pagel
Summary: In this study, we investigated the sorption-limited biodegradation of glyphosate and its main transformation product AMPA in soil using microcosm experiments. Our findings suggest that the degradation of both compounds is influenced by sorption processes, with a biphasic dissipation pattern. The model simulations also indicate that while glyphosate is rapidly transformed in solution, AMPA persists in soil due to its higher dissolved and bioavailable fraction.
JOURNAL OF ENVIRONMENTAL QUALITY
(2023)
Article
Engineering, Environmental
Pankaj Bhatt, Tushar Joshi, Kalpana Bhatt, Wenping Zhang, Yaohua Huang, Shaohua Chen
Summary: The widespread use of glyphosate poses a threat to living organisms, but microbes can degrade it with specific enzymes, including glyphosate oxidoreductase and C-P lyase. This study used molecular docking and dynamics simulations to investigate how glyphosate interacts with these enzymes and maintains stability in aqueous environments. The results provide insights into the role of these enzymes in bioremediation of glyphosate.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Dayanne Silva Borges, Lara Vecchi, Deysse Carla Tolentino Barros, Vinicius Marques Arruda, Helen Soares Valenca Ferreira, Matheus Fernandes da Silva, Joyce Ferreira da Costa Guerra, Raoni Pais Siqueira, Thaise Goncalves Araujo
Summary: This study evaluated the effects of glyphosate (GLY) and its metabolite AMPA on prostate cell lines. It was observed that high concentrations of GLY and AMPA reduced cell viability, while lower concentrations increased clonogenicity and oxidative stress in non-tumorigenic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
Summary: This study aimed to evaluate the levels of glyphosate and its metabolite AMPA in Moroccan children, identify predictors, and conduct a risk assessment. The study found that glyphosate and AMPA were detected in the urine of 73% and 75% of children, respectively, with higher concentrations in younger children and those living near pesticide spraying fields. Factors such as drinking water source and household income were also associated with AMPA concentration. The health risk assessment showed low risk for the target population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Joanna K. Winstone, Khyatiben Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte, Ramon Velazquez
Summary: This study provides the first evidence that glyphosate infiltrates the brain, upregulates the expression of TNF alpha and soluble A beta, and disrupts the transcriptome in a dose-dependent manner. These findings suggest that exposure to this herbicide may have detrimental effects on the health of the general population.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Martha Kimani, Evgeniia Kislenko, Kornelia Gawlitza, Knut Rurack
Summary: In this study, molecular imprinting was combined with direct fluorescence detection to improve the solubility of Glyphosate (GPS) in organic solvents and detect GPS in a direct and quantitative manner. The use of GPS-THA MIPs displayed better selectivity against competing molecules, and the THA(+) counterion was found to be a more powerful phase transfer agent in a biphasic assay.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Florent Rossi, Louis Carles, Florence Donnadieu, Isabelle Batisson, Joan Artigas
Summary: The study investigates the individual degrading behavior of bacterial strains isolated from glyphosate-degrading stream biofilms, revealing different and complementary glyphosate degradation pathways for bacteria co-existing in stream biofilms. Different bacterial strains showed variations in the degradation speed, pathway utilization, and accumulation of degradation products for glyphosate and its metabolite AMPA.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Karen Larsen, Adrian Lifschitz, Rocio Fernandez San Juan, Guillermo Virkel
Summary: This study investigated the metabolism of GLY and AMPA in the ruminal environment of cattle and evaluated their distribution in the ruminal content. The results showed that there were no metabolites of GLY and AMPA in the rumen of cattle, and they were mainly present in the fluid phase of the ruminal content. This indicates a high metabolic stability of GLY and AMPA in the ruminal environment, which may result in a rapid flow into the posterior gastrointestinal tract.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Analytical
Martina Vrablova, Katerina Smutna, Ivan Koutnik, Tomas Prostejovsky, Radim Zebrak
Summary: Glyphosate is a widely used pesticide. In order to tackle the issue of glyphosate removal, photocatalysis technology and a new sensor approach have been introduced. The aim of the research was to design and test an SPRi biosensor suitable for glyphosate degradation and the experimental results were recorded.
Article
Chemistry, Applied
Paola Nocera, Joanna Bajsa-Hirschel, Marco Masi, Samir A. Ross, Charles L. Cantrell, Stephen O. Duke, Giuseppe Surico, Antonio Evidente
Summary: An investigation of secondary metabolites in Thymelaea hirsuta from Lampedusa revealed ten compounds of different classes. Some compounds showed slight phytotoxicity to lettuce but were not active against Agrostis stolonifera. Only one compound had activity against three Colletotrichum species, but was less effective than the commercial fungicide captan.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Zhiqiang Pan, Joanna Bajsa-Hirschel, Justin N. Vaughn, Agnes M. Rimando, Scott R. Baerson, Stephen O. Duke
Summary: The study successfully revealed the biosynthesis pathway of sorgoleone in a heterologous host plant, and found that in vivo synthesized sorgoleone caused severe phytotoxicity to leaf tissues, resulting in the formation of necrotic lesions. Transcriptional analysis indicated that the compound impaired the photosynthetic system by downregulating gene expression for photosynthesis apparatus and upregulating proteasomal genes, contributing to the phytotoxicity of sorgoleone.
Article
Agriculture, Multidisciplinary
Chen-Sheng Yu, Qiao Wang, Joanna Bajsa-Hirschel, Charles L. Cantrell, Stephen O. Duke, Xing-Hai Liu
Summary: Nicotinic acid, also known as niacin, is a natural product found in plants and animals. In this study, N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized as potential herbicides. Some of these compounds showed promising herbicidal activity and could be used for the development of new herbicides against monocotyledonous weeds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agronomy
Stephen O. Duke, Franck E. Dayan
Summary: The demand for new herbicide modes of action has surged due to the evolving resistance of weeds to existing commercial herbicides. Natural products possess many potential new modes of action that have not been utilized by current herbicides, but have yet to be developed for various reasons. Efforts are being made to identify new herbicide targets through pharmaceutical target sites, metabolomic and proteomic information, and the use of artificial intelligence and machine learning. It is likely that new herbicides with new modes of action will be introduced within the next decade to address herbicide resistance management.
PEST MANAGEMENT SCIENCE
(2022)
Article
Agronomy
Vitor M. Anunciato, Leandro Bianchi, Giovanna L. G. C. Gomes, Edivaldo D. Velini, Stephen O. Duke, Caio A. Carbonari
Summary: Hormesis induced by low glyphosate doses in Digitaria insularis may provide an advantage for the dissemination of this species, altering the weed flora. Glyphosate-resistant biotypes require higher doses for stimulation compared to glyphosate-susceptible biotypes, potentially favoring the selection of resistant biotypes in glyphosate-sprayed fields and increasing infestation rates.
PEST MANAGEMENT SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Li-Jing Min, Han Wang, Joanna Bajsa-Hirschel, Chen-Sheng Yu, Bin Wang, Meng-Meng Yao, Liang Han, Charles L. Cantrell, Stephen O. Duke, Na-Bo Sun, Xing-Hai Liu
Summary: In this study, thirty novel dioxolane ring compounds were designed and synthesized. Their chemical structures were confirmed, and bioassays showed that these compounds exhibited excellent fungicidal and herbicidal activity. The study also revealed their target in plants and the mechanism of enzyme inhibition. The structure-activity relationships were discussed, providing useful information for designing more active compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agronomy
Stephen O. Duke
Summary: Resveratrol and pterostilbene, produced by various plant species, have antimicrobial and nutraceutical properties. Pterostilbene appears to be more active and bioavailable for most effects. However, dietary levels of these compounds are insufficient for health benefits, requiring supplementation or genetically modified crops.
Article
Biochemistry & Molecular Biology
Zhe-Cheng Wei, Qiao Wang, Li-Jing Min, Joanna Bajsa-Hirschel, Charles L. Cantrell, Liang Han, Cheng-Xia Tan, Jian-Quan Weng, Yu-Xin Li, Na-Bo Sun, Stephen O. Duke, Xing-Hai Liu
Summary: New niacinamide derivatives containing chiral flexible chains were synthesized for the discovery of lead compounds with high fungicidal or herbicidal activity. The compound (S)-2-(2-chloronicotinamido)propyl-2-methylbenzoate (3i) exhibited good fungicidal activity against Botryosphaeria berengriana, with similar potency as the positive control. Compound 3i showed no phytotoxicity and could be used as a fungicide on crops. Molecular docking simulations were conducted to study the structure-activity relationships (SAR) with the fungal succinate dehydrogenase.
Article
Agronomy
Stephen O. Duke
Summary: Microbial biopesticides have been successful in controlling plant pathogens and insects in crops, but there have been fewer successes for microbial bioherbicides. Despite numerous publications and commercial introductions, marketed microbial bioherbicide products for use in agriculture have largely been unsuccessful. This article discusses the potential advantages and limitations of microbial bioherbicides, as well as technologies to overcome these limitations. The use of killed microbial products and genetic modifications are likely to expand the future use of microbial bioherbicides.
PEST MANAGEMENT SCIENCE
(2023)
Review
Agronomy
Abigail L. Barker, John Pawlak, Stephen O. Duke, Roland Beffa, Patrick J. Tranel, Joe Wuerffel, Bryan Young, Aimone Porri, Rex Liebl, Raphael Aponte, Douglas Findley, Michael Betz, Jens Lerchl, Stanley Culpepper, Kevin Bradley, Franck E. Dayan
Summary: This article reviews the importance and current state of PPO-inhibiting herbicides, which have been used for 60 years since their first introduction. Recent increased interest in PPO-inhibiting herbicides, due to their increased use and cases of resistance, has led to a better understanding of the mechanism of action of PPO inhibitors. The article discusses the importance of the two isoforms of PPO in plants, current knowledge of target-site resistance mechanisms, non-target site resistance cases, and crop selectivity mechanisms. It emphasizes the need for consistent and reproducible greenhouse screening and target-site mutation assays to effectively study and compare PPO-inhibitor resistance cases.
Article
Agronomy
Vitor Simionato Bidoia, Jose Cristimiano dos Santos Neto, Cleber Daniel de Goes Maciel, Leandro Tropaldi, Caio Antonio Carbonari, Stephen Oscar Duke, Leonardo Bianco de Carvalho
Summary: This study examined the effects of recommended application rates of glyphosate on glyphosate-resistant maize. The results showed that glyphosate had no significant effects on the growth, grain composition, mineral content, grain quality, or yield of GR maize.
Article
Agriculture, Multidisciplinary
Charles L. Cantrell, Maria Lucia Travaini, Joanna Bajsa-Hirschel, Lara D. Svendsen, Amber Reichley, Gustavo M. Sosa, Seong Jong Kim, Prabin Tamang, Kumudini Meepagala, Stephen O. Duke
Summary: In this study, the effect of O-alkylation and O-arylalkylation on the herbicidal and antifungal activity of khellin and visnagin analogues was examined. The results showed that O-demethyl butylated visnagin analogue exhibited the highest herbicidal activity, while O-demethyl ethylated analogues of khellin and visnagin showed good antifungal activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Dionisio Luiz Pisa Gazziero, Alexandre Ferreira da Silva, Omar Roberto da Silveira, Stephen O. Duke, Antonio Luiz Cerdeira
Summary: Glyphosate-resistant palmer amaranth, a difficult weed to control, was found in Brazil in 2015 and caused significant yield losses. Immediate containment and eradication measures were implemented, including the establishment of a committee and training of agricultural inspectors. The spread of the weed was linked to the importation of used machinery, highlighting the importance of adopting effective measures to prevent seed dispersal.
ADVANCES IN WEED SCIENCE
(2023)
Article
Environmental Sciences
Regina G. Belz, Caio A. Carbonari, Stephen O. Duke
Summary: Hormesis is a common response of both herbicide-susceptible and herbicide-resistant plants to herbicides. There is growing evidence that hormesis plays a role in the changes in sensitivity of weed populations to herbicides, enhancing the propagation and spread of more vigorous plants.
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2022)
Review
Plant Sciences
Stephen O. Duke, Zhiqiang Pan, Joanna Bajsa-Hirschel, C. Douglas Boyette
Summary: There is a high demand for more natural means of pest management, particularly in weed management, and farmers are seeking herbicides with new chemistries or modes of action that are not affected by current weed resistances. Natural compounds can offer solutions to these needs, either as they are or as templates for improved herbicides. However, natural compounds have been under-utilized compared to insecticides and fungicides for herbicide purposes. Microbial biocontrol agents have had limited impact on weed management in crops, despite extensive research. On the other hand, microbial biopesticides have been successful in managing insect pests and plant pathogens. The reasons for these differences and potential solutions are discussed. The development of killed microbial preparations containing potent phytotoxins and the use of precision and smart spray systems can improve the effectiveness and economics of natural product-based herbicides and microbial bioherbicides.
ADVANCES IN WEED SCIENCE
(2022)