Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy

Enhanced identification of the in vivo metabolites of Ecliptae Herba in rat plasma by integrating untargeted data-dependent MS2 and predictive multiple reaction monitoring-information dependent acquisition-enhanced product ion scan

(2019) Mengrong Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Glycosidic compounds from Cassia obtusifolia seeds and their inhibitory effects on OATs, OCTs and OATPs

(2019) Shuangyan Wang et al.   Phytochemistry Letters

Validated UPLC-MS/MS method for quantification of seven compounds in rat plasma and tissues: Application to pharmacokinetic and tissue distribution studies in rats after oral administration of extract of Eclipta prostrata L.

(2018) Guangyan Du et al.   BIOMEDICAL CHROMATOGRAPHY

Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus

(2018) Xu Pang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Two new naphthalene glycosides from the seeds of Cassia obtusifolia

(2018) Xu Pang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

New anthraquinone and eurotinone analogue from the seeds of Senna obtusifolia and their inhibitory effects on human organic anion transporters 1 and 3

(2018) Xu Pang et al.   NATURAL PRODUCT RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Simultaneously targeted and untargeted multicomponent characterization of Erzhi Pill by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry

(2018) Ling-ling Fu et al.   JOURNAL OF CHROMATOGRAPHY A

Bioactive diarylheptanoids and stilbenes from the rhizomes of Dioscorea septemloba Thunb

(2017) Yi Zhang et al.   FITOTERAPIA

Modeling and optimizing inhibitory activities of Nelumbinis folium extract on xanthine oxidase using response surface methodology

(2017) Mangmang Sang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

(2017) Xu Pang et al.   NATURAL PRODUCT RESEARCH

From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity

(2017) Xue Wang et al.   TOXICOLOGICAL SCIENCES

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

(2017) Wei Wu et al.   Scientific Reports

Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb

(2016) Yi Zhang et al.   FITOTERAPIA

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3

(2016) Chia-Hsiang Hsueh et al.   MOLECULAR PHARMACEUTICS

Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor

(2015) Ke Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triglyceride accumulation inhibitory effects of new chromone glycosides fromDrynaria fortunei

(2015) Lifeng Han et al.   NATURAL PRODUCT RESEARCH

NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis

(2014) J Yao et al.   Cell Death & Disease

Otolaryngology, Head and Neck Surgery

(2014) Tsung-Lin Yang et al.   Biomed Research International

Transporter Studies in Drug Development: Experience to Date and Follow-Up on Decision Trees From the International Transporter Consortium

(2013) D Tweedie et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Wedelolactone, a Naturally Occurring Coumestan, Enhances Interferon-γ Signaling through Inhibiting STAT1 Protein Dephosphorylation

(2013) Zhimin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

(2013) Yi Zhang et al.   MOLECULES

Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells

(2012) Seyoung Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy

(2012) Thomas E.R. Baudoux et al.   KIDNEY INTERNATIONAL

Potent Inhibitors of Human Organic Anion Transporters 1 and 3 from Clinical Drug Libraries: Discovery and Molecular Characterization

(2012) Peng Duan et al.   MOLECULAR PHARMACEUTICS

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)

(2011) Chi Chun Wong et al.   BIOCHEMICAL PHARMACOLOGY

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid

(2011) Bojan Jelaković et al.   KIDNEY INTERNATIONAL

Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I

(2011) Xiang Xue et al.   MOLECULAR PHARMACEUTICS

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

(2010) Yong Zhang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism

(2009) Ying Xiao et al.   ACTA PHARMACOLOGICA SINICA

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy

(2009) Nadiya Bakhiya et al.   TOXICOLOGY

Multiple organic anion transporters contribute to net renal excretion of uric acid

(2008) Satish A. Eraly et al.   PHYSIOLOGICAL GENOMICS