期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 28, 期 9, 页码 1516-1519出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2018.03.080
关键词
Oleaceae; Ligustrum lucidum; Secoiridoid; Influenza A virus
资金
- Key Program for National Natural Science Foundation of China [81630106]
- National Infrastructure of Microbial Resources [NIMR-2017-3]
A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 mu M, respectively, which were better than the positive control Ribavirin (IC50 22.6 mu M). (C) 2018 Elsevier Ltd. All rights reserved.
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