Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment

(2020) Vincent J. Munster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism

(2019) Craig Schindewolf et al.   Viruses-Basel

Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection

(2019) Courtney E. Comar et al.   mBio

Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3′-terminal adenylyltransferase activity

(2019) Jana Tvarogová et al.   JOURNAL OF VIROLOGY

Modulation of sialic acid dependence influences the CNS transduction profile of adeno-associated viruses

(2019) Blake H. Albright et al.   JOURNAL OF VIROLOGY

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Combination and inducible adjuvants targeting nucleic acid sensors

(2018) Burcu Temizoz et al.   CURRENT OPINION IN PHARMACOLOGY

An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

(2018) Xufang Deng et al.   VIROLOGY

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

(2017) Xufang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication

(2017) Eveline Kindler et al.   PLoS Pathogens

Raising the flag on marine alien fouling species

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Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

(2016) Joshua M. Thornbrough et al.   mBio

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

(2016) Christopher J. Neufeldt et al.   PLoS Pathogens

Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation

(2016) Yu-Hui Peng et al.   PLoS One

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins

(2015) Denys A. Khaperskyy et al.   JOURNAL OF VIROLOGY

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

(2012) Ling Zhao et al.   Cell Host & Microbe

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

(2012) Gretja Schnell et al.   PLoS Pathogens

Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression

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Poly(A) at the 3' End of Positive-Strand RNA and VPg-Linked Poly(U) at the 5' End of Negative-Strand RNA Are Reciprocal Templates during Replication of Poliovirus RNA

(2010) B. P. Steil et al.   JOURNAL OF VIROLOGY

Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes

(2010) K. M. Rose et al.   JOURNAL OF VIROLOGY

Biochemical Characterization of Arterivirus Nonstructural Protein 11 Reveals the Nidovirus-Wide Conservation of a Replicative Endoribonuclease

(2009) D. D. Nedialkova et al.   JOURNAL OF VIROLOGY

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

(2009) A. Pichlmair et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

(2008) V. Krahling et al.   JOURNAL OF VIROLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY

The viral RNase Erns prevents IFN type-I triggering by pestiviral single- and double-stranded RNAs

(2008) Philippe Mätzener et al.   VIRUS RESEARCH

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY