IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Principles and approaches for reproducible scoring of tissue stains in research

(2018) David K. Meyerholz et al.   LABORATORY INVESTIGATION

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

(2018) Wolfgang Koestner et al.   PLoS Pathogens

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Emerging infectious diseases: A proactive approach

(2017) David E. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

(2017) Kun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity

(2016) Laura J. Baseler et al.   AMERICAN JOURNAL OF PATHOLOGY

Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014

(2016) Dianna L. Ng et al.   AMERICAN JOURNAL OF PATHOLOGY

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

(2016) Sophia Davidson et al.   EMBO Molecular Medicine

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells

(2016) Janne Tynell et al.   JOURNAL OF GENERAL VIROLOGY

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome

(2016) Christopher M. Coleman et al.   JOURNAL OF VIROLOGY

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

(2016) Chan-Ki Min et al.   Scientific Reports

Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report

(2015) Uh Jin Kim et al.   ANTIVIRAL THERAPY

IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study

(2015) Sarah Shalhoub et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

(2015) Michelle Goritzka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

(2015) Sophia Davidson et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

(2015) Vivian A. Scheuplein et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Ribavirin and interferon (IFN)-alpha-2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus (MERS-CoV): a preliminary report of two cases

(2014) Mohammed Khalid et al.   ANTIVIRAL THERAPY

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

(2014) Jaffar A. Al-Tawfiq et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The Pathology and Pathogenesis of Experimental Severe Acute Respiratory Syndrome and Influenza in Animal Models

(2014) J.M.A. van den Brand et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Type I IFN-Mediated Protection of Macrophages and Dendritic Cells Secures Control of Murine Coronavirus Infection

(2014) L. Cervantes-Barragan et al.   JOURNAL OF IMMUNOLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

(2014) Ali S Omrani et al.   LANCET INFECTIOUS DISEASES

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Human Cell Tropism and Innate Immune System Interactions of Human Respiratory Coronavirus EMC Compared to Those of Severe Acute Respiratory Syndrome Coronavirus

(2013) F. Zielecki et al.   JOURNAL OF VIROLOGY

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

(2013) Darryl Falzarano et al.   NATURE MEDICINE

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

(2013) E. de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

Intranasal Treatment with Poly(I{middle dot}C) Protects Aged Mice from Lethal Respiratory Virus Infections

(2012) J. Zhao et al.   JOURNAL OF VIROLOGY

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

(2010) J. Zhao et al.   JOURNAL OF VIROLOGY

A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits

(2010) LuLu Gao et al.   VACCINE

Autocrine Interferon Priming in Macrophages but Not Dendritic Cells Results in Enhanced Cytokine and Chemokine Production after Coronavirus Infection

(2010) H. Zhou et al.   mBio

Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation

(2009) Pui Y. Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY