Review
Biochemistry & Molecular Biology
Cagla Kiser, Ceren Perihan Gonul, Melis Olcum, Sermin Genc
Summary: SFN, a dietary phytochemical found in cruciferous vegetables, is known for its antioxidant and anti-inflammatory effects, particularly in suppressing NLRP3 inflammasome activation. Research has shown that SFN may have therapeutic potential for various disorders.
MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Bora Tastan, Burak Arioz, Sermin Genc
Summary: The NLRP3 inflammasome is a multiprotein complex that plays a crucial role in the immune system and its abnormal activation is associated with various diseases. The transcription factor Nrf2, which regulates cellular stress response, has shown potential as a therapeutic target to inhibit NLRP3 inflammasome activation. This review discusses the current understanding of NLRP3 inflammasome activation and Nrf2 pathways, as well as the use of Nrf2 activators in central nervous system disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaoxue Du, Nashwa Amin, Linhao Xu, Benson O. A. Botchway, Bo Zhang, Marong Fang
Summary: Curcumin regulates the NLRP3 pathway to provide neuroprotection and prevent nerve cell loss in ischemic stroke. Curcumin therapy has the potential to delay the progression of brain damage by penetrating the blood-brain barrier and inhibiting inflammation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Wudi Hao, Chenyu Hao, Chengrong Wu, Yuqing Xu, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure can induce neuronal cell pyroptosis and neuroinflammation through the DDX3X-NLRP3 inflammasome signaling pathway, which can be alleviated by Rsv through activating SIRT1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Kemal Ugur Tufekci, Ilkcan Ercan, Kamer Burak Isci, Melis Olcum, Bora Tastan, Ceren Perihan Gonul, Kursad Genc, Sermin Genc
Summary: The NLRP3 inflammasome plays a crucial role in host defense against pathogens, but its overactivation can lead to inflammatory diseases. Studies have shown that SFN can inhibit the NLRP3 inflammasome-mediated inflammatory response.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Atala B. Jena, Umesh C. Dash, Asim K. Duttaroy
Summary: This study investigated the interaction between curcumin and EGCG, plant-derived compounds, with NLRP3 complex using in silico approach. The results showed that curcumin and EGCG had higher binding affinity for NLRP3 protein compared to other complex proteins, suggesting their potential impact on the complex's function. Protein-protein interaction studies further confirmed the efficacy of these compounds in hindering the formation of NLRP3 complex. The therapeutic effect of curcumin and EGCG may be mediated by preventing the development of the NLRP3 complex.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Anju Jaiswal, D. Dash, Rashmi Singh
Summary: This study found that intranasal administration of curcumin can reduce asthma exacerbations caused by endotoxin by modulating NLRP3 activation, and it also has anti-inflammatory effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae-Hwan Kim, Ho-Soo Lee, Young-Suk Yoo, June Heo, Jae-Ho Lee, Myung-Hee Kwon, Ho Chul Kang, Jong-Soo Lee, Hyeseong Cho
Summary: The NLRP3 inflammasome is activated through mitochondria-mediated ubiquitination by the E3 ligase MARCH5. Knockout of MARCH5 leads to an impaired secretion of IL-1β and IL-18 in myeloid cells, as well as a decreased mortality rate upon infection. MARCH5-dependent NLRP3 ubiquitination is essential for NLRP3-NEK7 complex formation and NLRP3 oligomerization.
Article
Biochemistry & Molecular Biology
Watunyoo Buakaew, Rungnapa Pankla Sranujit, Chanai Noysang, Yordhathai Thongsri, Pachuen Potup, Nitra Nuengchamnong, Nungruthai Suphrom, Kanchana Usuwanthim
Summary: The extract and active compound lupeol from Citrus hystrix leaves showed potent anti-inflammatory activities by targeting NF-kappa B and NLRP3 signaling pathways.
Article
Food Science & Technology
Yingjie Wang, Fangju Liu, Mengru Liu, Xin Zhou, Min Wang, Kexin Cao, Sanjun Jin, Anshan Shan, Xingjun Feng
Summary: This study investigated the protective effects of curcumin against AFB1-induced liver injury in mice. Curcumin was found to attenuate AFB1-induced weight loss and liver damage by mitigating alterations in pathology and liver function. It reduced the accumulation of AFB1-DNA adducts in the liver and alleviated hepatotoxicity by inhibiting oxidative stress and potentiating detoxification enzymes. Additionally, curcumin reduced AFB1-induced pyroptosis and modulated the NLRP3 inflammasome and Nrf2 signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Immunology
Yanpin Gu, Yongcheng Zhu, Guoliang Deng, Songjun Liu, Yang Sun, Wen Lv
Summary: The study found that AI-44 alleviated gouty arthritis in mice by inhibiting the activation of NLRP3 inflammasome triggered by MSU, possibly through suppressing the interaction between cathepsin B and NLRP3, and reducing the enzymatic activity of cathepsin B.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Mei-Hsin Hsu, Yi-Chuan Huang, Yu-Chieh Chen, Jiunn-Ming Sheen, Li-Tung Huang
Summary: Endothelial dysfunction is characterized by disturbances in nitric oxide bioavailability and increased circulating asymmetric dimethylarginine (ADMA). We induced endothelial dysfunction in young male rats and observed cognitive deficits, increased NLRP3 inflammasome activation, decreased cytokine activation and tight junction proteins, and altered microbiota composition. Resveratrol was found to have beneficial effects in alleviating these effects.
Article
Neurosciences
Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Genc
Summary: Our study demonstrates that resveratrol suppresses NLRP3 inflammasome and miR-155 expression in microglia by modulating AMPK and Sirt1 pathways, revealing its anti-inflammatory properties.
NEUROTOXICITY RESEARCH
(2021)
Article
Immunology
Kemal Ugur Tufekci, Ilkcan Ercan, Kamer Burak Isci, Melis Olcum, Bora Tastan, Ceren Perihan Gonul, Kursad Genc, Sermin Genc
Summary: The NLRP3 inflammasome plays a crucial role in host defense against pathogens, but its overactivation can lead to inflammatory diseases. Studies have shown that SFN can inhibit the NLRP3 inflammasome-mediated inflammatory response.
IMMUNOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Melis Olcum, Kemal Ugur Tufekci, Devrim Yagmur Durur, Bora Tastan, Irem Nur Gokbayrak, Kursad Genc, Sermin Genc
Summary: Ethyl pyruvate has anti-inflammatory and pro-metabolic effects, effectively suppressing NLRP3 inflammasome activation in microglial cells by regulating miR-223 and the NF-κB/HMGB1 axis.
Article
Biochemistry & Molecular Biology
Devrim Yagmur Durur, Bora Tastan, Kemal Ugur Tufekci, Melis Olcum, Hamdiye Uzuner, Gokhan Karakulah, Gorsev Yener, Sermin Genc
Summary: Alzheimer's disease (AD) is a severe neurodegenerative disease in the elderly population, and there is still a lack of definitive diagnosis and treatment methods. This study identified let-7e as a potential biomarker for AD diagnosis by studying the altered miRNA content in small neuron-derived extracellular vesicles (sNDEVs). Furthermore, it was found that AD patient-derived sNDEVs induce a neuroinflammatory response.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Review
Immunology
Bora Tastan, Burak Arioz, Sermin Genc
Summary: The NLRP3 inflammasome is a multiprotein complex that plays a crucial role in the immune system and its abnormal activation is associated with various diseases. The transcription factor Nrf2, which regulates cellular stress response, has shown potential as a therapeutic target to inhibit NLRP3 inflammasome activation. This review discusses the current understanding of NLRP3 inflammasome activation and Nrf2 pathways, as well as the use of Nrf2 activators in central nervous system disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gina Manda, Elena Milanesi, Sermin Genc, Cristina Mariana Niculite, Ionela Victoria Neagoe, Bora Tastan, Elena Mihaela Dragnea, Antonio Cuadrado
Summary: This review focuses on the arguments for using NRF2-directed co-treatment in RA and its limitations, highlighting the importance of NRF2 in RA through analysis of transcriptomic data and animal experiments. The potential of NRF2 activators in drug development and the interference of NRF2 with conventional anti-rheumatic therapies are also discussed.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Emre Tarakcioglu, Bora Tastan, Burak Arioz, Kemal Ugur Tufekci, Sermin Genc
Summary: This study investigates how melatonin suppresses the activation of inflammasomes by altering the microRNA transcriptome of microglial cells. The researchers identify miR-155-3p as an upregulated miRNA with inflammasome activation and downregulated with melatonin treatment. Further experiments support the idea that the protective effects of melatonin in inflammasome activation are partly associated with miR-155-3p inhibition.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Bedir Irem Eltutan, Cagla Kiser, Ilkcan Ercan, Kemal Ugur Tufekci, Defne Engur, Sermin Genc, Abdullah Kumral
Summary: This study investigated the concentration-dependent effects of H2O2 on neural stem cell differentiation, revealing that high doses of exogenous H2O2 suppress neural stem cell differentiation through the AKT and p38 pathways. This has important implications for understanding the developmental process and molecular mechanisms of the nervous system.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Neurosciences
Kemal Ugur Tufekci, Jens Allmer, Kursat Bora Carman, Erhan Bayram, Yasemin Topcu, Semra Hiz, Sermin Genc, Uluc Yis
Summary: This study aimed to investigate the role of antiviral miRNAs in the pathogenesis of SSPE and analyze the interaction between host antiviral miRNAs and virus genes. Results showed that IFN-beta-modulated miR-196b, miR-296, and miR-431 were significantly upregulated in SSPE patients, with predicted binding regions in measles virus genomic RNA for miR-296 and miR-196b.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2021)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
