Sulfonyl Azoles in the Synthesis of 3-Functionalized Azole Derivatives

A highly enantioselective thiolation of sulfonyl indoles to access 3-sec-sulfur-substituted indoles in water

(2016) Ping Chen et al.   CHEMICAL COMMUNICATIONS

The Nitro to Carbonyl Conversion (Nef Reaction): New Perspectives for a Classical Transformation

(2015) Roberto Ballini et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Arylation of 3-Indolylmethanols: Enantioselective Synthesis of 3,3′-Bis(indolyl)oxindoles with High Atom Economy

(2015) Xiao-Xue Sun et al.   ChemCatChem

Strategies for the asymmetric functionalization of indoles: an update

(2015) Renato Dalpozzo   CHEMICAL SOCIETY REVIEWS

Catalytic Asymmetric Cyanation of Alkylideneindolenines Generated from Sulfonylalkylindoles

(2015) Kohsuke Ohmatsu et al.   CHEMISTRY LETTERS

Organocatalytic Highly Enantioselective Substitution of 3-(1-Tosylalkyl)indoles with Oxindoles Enables the First Total Synthesis of (+)-Trigolutes B

(2015) Jian-Zhou Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Formal Asymmetric Organocatalytic [3+2] Cyclization between Enecarbamates and 3-Indolylmethanols: Rapid Access to 3-Aminocyclopenta[b]indoles

(2015) Clément Lebée et al.   CHEMISTRY-A EUROPEAN JOURNAL

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

(2015) Anna Domagala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of indazole motifs and their medicinal importance: An overview

(2015) Digambar D. Gaikwad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azole antifungals: 35 years of invasive fungal infection management

(2015) David Allen et al.   Expert Review of Anti-Infective Therapy

Synthesis of Bench-Stable Diarylmethylium Tetrafluoroborates

(2015) Margherita Barbero et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure and Reactivity of Indolylmethylium Ions: Scope and Limitations in Synthetic Applications

(2015) Elsa Follet et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organocatalytic Alkylation of Aldehydes and Enals Driven by the Direct Photoexcitation of Enamines

(2015) Mattia Silvi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tf2NH-Catalyzed Amide Synthesis from Vinyl Azides and Alcohols

(2015) Feng-Lian Zhang et al.   ORGANIC LETTERS

Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β-Keto Acids with 3-Hydroxy-3-indolyloxindoles

(2015) Xiao-Dong Tang et al.   ORGANIC LETTERS

3-(1-Arylsulfonylalkyl)-7-azaindoles as precursors of vinylogous imine intermediates for hetero-Michael addition reactions

(2015) Lunqiang Jin et al.   TETRAHEDRON

Facile synthesis of 3-sec-alkyl substituted 7-azaindoles by Michael addition of carbon nucleophiles to vinylogous imine intermediates generated in situ from 3-(1-arylsulfonylalkyl)-7-azaindoles

(2015) Gan Luo et al.   TETRAHEDRON LETTERS

Organocatalytic asymmetric Michael addition of benzofuran-2(3H)-ones to alkylideneindolenines generated in situ from arenesulfonylalkylindoles

(2015) Rongming Wang et al.   TETRAHEDRON LETTERS

Simple synthesis 11-substituted norcryptotackieine derivatives

(2015) Michał Nowacki et al.   RSC Advances

Nitroaldol (Henry) reaction of 2-oxoaldehydes with nitroalkanes as a strategic step for a useful, one-pot synthesis of 1,2-diketones

(2015) Alessandro Palmieri et al.   RSC Advances

Metal-Free Regioselective β-Alkylation of Pyrroles with Carbonyl Compounds and Hydrosilanes: Use of a Brønsted Acid as a Catalyst

(2014) Shota Nomiyama et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthetic Approaches to 3-(2-Nitroalkyl) Indoles and Their Use to Access Tryptamines and Related Bioactive Compounds

(2014) Stefano Lancianesi et al.   CHEMICAL REVIEWS

Applications of Bartoli indole synthesis

(2014) Giuseppe Bartoli et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in the synthesis of pyrroles by multicomponent reactions

(2014) Verónica Estévez et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Continuous-Flow Production of 3-Indolylmethanamines Mediated by an Immobilized Phosphoric Acid Catalyst

(2014) Laura Osorio-Planes et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regiospecific Synthesis of 7-Hydroxyindoles from Pyrroles by Anionic Benzannulation

(2014) Bidyut Kumar Dinda et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

General Suzuki Coupling of Heteroaryl Bromides by Using Tri-tert-butylphosphine as a Supporting Ligand

(2014) Yinjun Zou et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Synthesis of Optically Active Organophosphorus Compounds

(2014) Marek Dzięgielewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms

(2014) Anuradha Chowdhary et al.   Future Microbiology

Solvent-Free Enantioselective Organocatalyzed Aldol Reactions

(2014) Abraham Banon-Caballero et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Selective synthesis of 4-(sulfonyl)-methyl-1H-pyrazoles and (E)-4,5-dihydro-1H-pyrazoles from N-allenic sulfonylhydrazones

(2014) Yu Zhu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzed Asymmetric Cycloadditions of Vinylcyclopropanes and in Situ Formed Unsaturated Imines: Construction of Structurally and Optically Enriched Spiroindolenines

(2014) Ze-Shui Liu et al.   ORGANIC LETTERS

The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization of Indole Derivatives

(2014) Jing Luo et al.   ORGANIC LETTERS

Recent advances in Michael addition of H-phosphonates

(2014) A. Yu. Rulev   RSC Advances

Sulfuric acid functionalized MCM-41 coated on magnetite nanoparticles as a recyclable core–shell solid acid catalyst for three-component condensation of indoles, aldehydes and thiols

(2014) Alireza Khorshidi et al.   RSC Advances

Alkylideneindoleninium Ions and Alkylideneindolenines: Key Intermediates for the Asymmetric Synthesis of 3-Indolyl Derivatives

(2014) Liang Wang et al.   Asian Journal of Organic Chemistry

Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Construction of Chiral 3,3-Disubstituted Oxindoles

(2013) Jian-Zhou Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of 3-(2-Nitroalkyl)pyrroles from Sulfonylpyrroles and their Conversion to 6-Azaindole Derivatives

(2013) Stefano Lancianesi et al.   ADVANCED SYNTHESIS & CATALYSIS

A Photochemical Route to Benzo[a]carbazolesviaDomino Elimination/Electrocyclization of 2-Aryl-3-(1-tosylalkyl)indoles

(2013) Stefano Protti et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Developments in Asymmetric Phase-Transfer Reactions

(2013) Seiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Conjugate Addition of Diethylzinc to Vinylogous Imines Generatedin situfrom Sulfonyl Indoles

(2013) Chengyan Ni et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Phase Transfer Catalyzed Enantioselective and Diastereoselective Conjugate Additions of Glycinate Imine to Unsaturated Imines Formedin situfrom Sulfonylindoles

(2013) Jinquan Chen et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Scandium Triflate-Catalyzed Nucleophilic Additions to Indolylmethyl Meldrum’s Acid Derivatives via a Gramine-Type Fragmentation: Synthesis of Substituted Indolemethanes

(2013) Erin L. Armstrong et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Congested Spiro-cyclopentaneoxindoles via an Organocatalytic Cascade Reaction

(2013) Artur Noole et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Monofluoromethylation of C2-Arylindoles Using FBSM under Chiral Phase-Transfer Catalysis

(2013) Kohei Matsuzaki et al.   ORGANIC LETTERS

Acid-promoted Cascade Cyclization to Produce Fused-polycyclic Indole Derivatives

(2013) Takuya Yokosaka et al.   ORGANIC LETTERS

Enantioselective Michael Addition of 1,3-Diketones to Arenesulfonylalkylindoles: A Flexible Gateway to Optically Active 3-sec-Alkyl-Substituted Indoles Containing a Pyrazole Skeleton

(2013) Linhai Jing et al.   SYNTHESIS-STUTTGART

Asymmetric Organocatalysis and the Nitro Group Functionality

(2013) Alexander Cobb et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis and properties of 4-, 5-, 6- or 7-azaindoles

(2013) Jean-Yves Mérour et al.   TETRAHEDRON

Higher enantioselectivities in thiourea-catalyzed Michael additions under solvent-free conditions

(2013) Martina Hestericová et al.   TETRAHEDRON

Organocatalytic asymmetric Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles

(2013) Liangliang Yu et al.   TETRAHEDRON LETTERS

Hydrated ferric sulfate catalyzed synthesis of 3-[(alkyl/arylthio)(aryl)methyl]-1H-indole derivatives through one-pot reaction

(2013) Ajaz A. Dar et al.   TETRAHEDRON LETTERS

Asymmetric Friedel–Crafts addition of indoles to N-sulfonyl aldimines catalyzed by Cu(ii) chiral amino alcohol based Schiff base complexes

(2013) Prathibha Kumari et al.   Catalysis Science & Technology

Solvent-Free Non-Covalent Organocatalysis: Enantioselective Addition of Nitroalkanes to Alkylideneindolenines as a Flexible Gateway to Optically Active Tryptamine Derivatives

(2012) Mariafrancesca Fochi et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Asymmetric Vinylogous Michael Addition of Dicyanoolefins to Imine Intermediates Generatedin situfrom Arenesulfonylalkylindoles

(2012) Xing-Li Zhu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis and Functionalization of Unsymmetrical Arylsulfonyl Bisindoles and Bisbenzazoles

(2012) Stefano Lancianesi et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent efforts directed to the development of more sustainable asymmetric organocatalysis

(2012) José G. Hernández et al.   CHEMICAL COMMUNICATIONS

Indoles in Multicomponent Processes (MCPs)

(2012) Morteza Shiri   CHEMICAL REVIEWS

Double Axially Chiral Bisphosphorylimides Catalyzed Highly Enantioselective and Efficient Friedel-Crafts Reaction of Indoles with Imines

(2012) Kun Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Asymmetric Michael Addition of Oxazolones to Arylsulfonyl Indoles: Facile Access tosyn-Configured α,β-Disubstituted Tryptophan Derivatives

(2012) Chang-Wu Cai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Preparation and Characterization of Aryl or Heteroaryl(3-indolyl)methylium o-Benzenedisulfonimides

(2012) Margherita Barbero et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Cross Couplings of Benzylic Ammonium Salts and Boronic Acids: Stereospecific Formation of Diarylethanes via C–N Bond Activation

(2012) Prantik Maity et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient synthesis of α-substituted fluoroethenes

(2012) Samir K. Mandal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives

(2012) Alessandro Palmieri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

TFA-catalyzed C–N bond activation of enamides with indoles: efficient synthesis of 3,3-bisindolylpropanoates and other bisindolylalkanes

(2012) Hai-Yan Xu et al.   TETRAHEDRON

Recoverable silica-gel supported binam-prolinamides as organocatalysts for the enantioselective solvent-free intra- and intermolecular aldol reaction

(2012) Abraham Bañón-Caballero et al.   TETRAHEDRON

Pd-catalyzed addition of boronic acids to vinylogous imines: a convenient approach to 3-sec-alkyl substituted indoles

(2012) Liang-Liang Cao et al.   TETRAHEDRON LETTERS

Indole synthesis – something old, something new

(2012) Martyn Inman et al.   Chemical Science

Rhodium-Catalyzed Addition of Boronic Acids to Vinylogous Imines Generatedin situfrom Sulfonylindoles

(2011) Liang-Liang Cao et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic glycine and sulfonylindoles

(2011) Jiang Wang et al.   CHEMICAL COMMUNICATIONS

Selective Synthesis of β-Alkylpyrroles

(2011) Teruhisa Tsuchimoto   CHEMISTRY-A EUROPEAN JOURNAL

Regioselective Synthesis of 3-Substituted Pyrroles by Nucleophilic Addition of 3-(1-Arylsulfonylalkyl) Pyrroles Activated under Basic or Acid Conditions

(2011) Fabio Martinelli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Toward a rational control of solid acid catalysis for green synthesis and biomass conversion

(2011) Ken-ichi Shimizu et al.   Energy & Environmental Science

Eco-friendly synthesis of β-nitro ketones from conjugated enones: an important improvement of the Miyakoshi procedure

(2011) Serena Gabrielli et al.   GREEN CHEMISTRY

Tris(pentafluorophenyl)borane [B(C6F5)3]-catalyzed Friedel–Crafts reactions of activated arenes and heteroarenes with α-amidosulfones: the synthesis of unsymmetrical triarylmethanes

(2011) Ponnaboina Thirupathi et al.   TETRAHEDRON

A Two-Step Synthesis of Unsymmetrical 1,4-Disubstituted Carbazoles from Sulfonylindoles Under Heterogeneous Catalysis

(2010) Roberto Ballini et al.   ADVANCED SYNTHESIS & CATALYSIS

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

Exclusive Synthesis of β-Alkylpyrroles under Indium Catalysis: Carbonyl Compounds as Sources of Alkyl Groups

(2010) Teruhisa Tsuchimoto et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Michael Addition of Malononitrile to Vinylogous Imine Intermediates Generated in situ from Arylsulfonyl Indoles

(2010) Linhai Jing et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis ofsec-Alkyl-3-Substituted Indoles

(2010) Mark C. Dobish et al.   ORGANIC LETTERS

Ag-Catalyzed Diastereo- and Enantioselective Synthesis of β-Substituted Tryptophans from Sulfonylindoles

(2010) Bao-Hui Zheng et al.   ORGANIC LETTERS

Recent Applications of α-Amido Sulfones as in situ Equivalents of Activated Imines for Asymmetric Catalytic Nucleophilic Addition Reactions

(2010) Biaolin Yin et al.   SYNTHESIS-STUTTGART

Catalytic stereoselective benzylic C–H functionalizations by oxidative C–H activation and organocatalysis

(2009) Fides Benfatti et al.   CHEMICAL COMMUNICATIONS

Evolving Organic Synthesis Fostered by the Pluripotent Phenylsulfone Moiety

(2009) Ahmad El-Awa et al.   CHEMICAL REVIEWS

Bis- and Trisindolylmethanes (BIMs and TIMs)†

(2009) Morteza Shiri et al.   CHEMICAL REVIEWS

Synthesis of 3-(Tosylalkyl)indazoles and their Desulfonylation Reactions - A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel-Crafts Process

(2009) Silvia Campetella et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Methanes Having Four Different Carbon Substituents Utilizing Indium-Catalyzed Cleavage of Carbon-Pyrrolyl Bonds

(2009) Teruhisa Tsuchimoto et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Unsymmetrical Triarylmethanes by Chiral Brønsted Acids

(2009) Feng-Lai Sun et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Simple and EfficientFriedel-CraftsAlkylation of 1H-Indole with Electron-Deficient Alkenes Promoted by Zinc Acetate

(2009) Harshadas Mitaram Meshram et al.   HELVETICA CHIMICA ACTA

InBr3: A Versatile Catalyst for the Different Types of Friedel−Crafts Reactions

(2009) Ponnaboina Thirupathi et al.   JOURNAL OF ORGANIC CHEMISTRY

Reaction of carbon nucleophiles with alkylideneindazolium and alkylideneindolium ions generated from their 3-(1-arylsulfonylalkyl) indazole and indole precursors

(2009) Laura Marsili et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

(2009) Alessandro Palmieri et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Indium-Catalyzed Reductive Alkylation of Pyrroles with Alkynes and Hydrosilanes: Selective Synthesis of β-Alkylpyrroles

(2009) Teruhisa Tsuchimoto et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aldehydes with Arylsulfonyl Indoles

(2009) Yi Li et al.   ORGANIC LETTERS

A ‘Click’ Approach to the Synthesis of 3-[2-(1-Alkyltriazol-4-yl)ethyl]indoles

(2009) Marino Petrini et al.   SYNTHESIS-STUTTGART

Direct organocatalytic coupling of carboxylated piperazine-2,5-diones with indoles through conjugate addition of carbon nucleophiles to indolenine intermediates

(2009) Ramin Dubey et al.   TETRAHEDRON LETTERS

Novel cyclohexene derivatives as anti-sepsis agents: Synthetic studies and inhibition of NO and cytokine production

(2008) Masami Yamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Environmentally Benign Contemporary Friedel-Crafts Chemistry by Solid Acids

(2008) Sujaya Dasgupta et al.   CURRENT ORGANIC SYNTHESIS

Recent Advances in the Chemistry of Indazoles

(2008) Andreas Schmidt et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Improved preparation of alkyl 2-(3-indolyl)-3-nitroalkanoates under fully heterogeneous conditions: stereoselective synthesis of alkyl (E)-2-(3-indolyl)-2-alkenoates

(2008) Roberto Ballini et al.   TETRAHEDRON

Synthesis of indolylalkylphosphonates and 3-(1-diphenylphosphinoalkyl) indoles by reaction of 3-(1-arylsulfonylalkyl) indoles with phosphorus derivatives

(2008) Marino Petrini et al.   TETRAHEDRON LETTERS

Reaction of 3-(1-Arylsulfonylalkyl)-indoles with Easily Enolisable Derivatives Promoted by Potassium Fluoride on Basic Alumina

(2007) Roberto Ballini et al.   ADVANCED SYNTHESIS & CATALYSIS

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

(2007) Marie A. Colucci et al.   ORGANIC & BIOMOLECULAR CHEMISTRY