Umpolung Reactions of α-Imino Esters: Useful Methods for the Preparation of α-Amino Acid Frameworks

C-Selective and Diastereoselective Alkyl Addition to β,γ-Alkynyl-α-imino Esters with Zinc(II)ate Complexes

(2015) Manabu Hatano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C- and N-Selective Grignard Addition Reactions of α-Aldimino Esters in the Presence or Absence of Zinc(II) Chloride: Synthetic Applications to Optically Active Azacycles

(2015) Manabu Hatano et al.   ORGANIC LETTERS

Highly efficient sequential N,N,C-trialkylation of α- N -acyloxyimino esters

(2015) Isao Mizota et al.   TETRAHEDRON

N-Alkylation of α-Iminophosphonates and Application to Horner–Wadsworth–Emmons Reaction

(2014) Makoto Shimizu et al.   CHEMISTRY LETTERS

Tandem N-Alkylation/Vinylogous Aldol Reaction of β,γ-Alkenyl α-Iminoester

(2014) Hirotaka Tanaka et al.   ORGANIC LETTERS

Asymmetric Synthesis of α-Allyl-α-Aryl α-Amino Acids by Tandem Alkylation/π-Allylation of α-Iminoesters

(2014) John M. Curto et al.   ORGANIC LETTERS

Isothiourea-Mediated One-Pot Synthesis of Trifluoromethyl Substituted 2-Pyrones

(2014) Pei-Pei Yeh et al.   ORGANIC LETTERS

Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitors

(2013) Xue-Ping Chu et al.   CHINESE CHEMICAL LETTERS

Regioselective Tandem N-Alkylation/C-Acylation of β,γ-Alkynyl α-Imino Esters

(2013) Isao Mizota et al.   ORGANIC LETTERS

Highly Diastereoselective TandemN-Alkylation-Mannich Reaction of α-Imino Esters

(2013) Makoto Shimizu et al.   Asian Journal of Organic Chemistry

Synthesis of Indolin-3-ones and Tetrahydro-4-quinolones from α-Imino Esters

(2013) Makoto Shimizu et al.   Asian Journal of Organic Chemistry

N,N-Di- and N,N,C-Trialkylation of α-Sulfoximino Esters

(2012) Shingo Hata et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Enantioselective and Solvent-Controlled Diastereoselective Mannich Reaction of Isatin Imines with Hydroxyacetone: Synthesis of 3-Substituted 3-Aminooxindoles

(2012) Qi-Xiang Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

The Vinylogous Aldol Reaction of Unsaturated Esters and Enolizable Aldehydes Using the Novel Lewis Acid Aluminum Tris(2,6-di-2-naphthylphenoxide)

(2012) Jeffrey A. Gazaille et al.   ORGANIC LETTERS

Metal-Free N–H Insertions of Donor/Acceptor Carbenes

(2012) Stephanie R. Hansen et al.   ORGANIC LETTERS

Integrated reactions using addition to conjugated imines and iminium salts

(2012) Takafumi Nishi et al.   PURE AND APPLIED CHEMISTRY

Synthesis of γ,δ-unsaturated quaternary α-alkylamino acids using umpolung reaction and Claisen rearrangement

(2012) Isao Mizota et al.   TETRAHEDRON LETTERS

Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents

(2012) Yusuke Mizutani et al.   TETRAHEDRON LETTERS

Combined α,α-dialkylprolinol ether/Brønsted acid promotes Mannich reactions of aldehydes with unactivated imines. An entry to anti-configured propargylic amino alcohols

(2012) Enrique Gómez-Bengoa et al.   Chemical Science

Enantioselective Iridium-Catalyzed Vinylogous Reformatsky-Aldol Reaction from the Alcohol Oxidation Level: Linear Regioselectivity by Way of Carbon-Bound Enolates

(2011) Abbas Hassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The discovery of AZD9164, a novel muscarinic M3 antagonist

(2011) Antonio Mete et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress†

(2011) Giovanni Casiraghi et al.   CHEMICAL REVIEWS

Efficient Mannich Reaction Using Iminium Salts Generated from Glycine Derivatives

(2011) Makoto Shimizu et al.   CHEMISTRY LETTERS

Asymmetric Trienamine Catalysis for the Construction of Structurally Rigid Cyclic α,α-Disubstituted Amino Acid Derivatives

(2011) Hao Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Unexpected Formation of (E)-4-Alkene 1,3-Diketones from the Three-Component Reaction of Lithium Selenolates with 1-(1-Alkynyl)cyclopropyl Ketones and Aldehydes

(2011) Jianfeng Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

A Dual-Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition ofO-Acylated Azlactones to Isoquinolines

(2011) Chandra Kanta De et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A diastereoselective aza-Diels–Alder reaction of N-aryl-1-azadienes derived from α-amino acids with enamines

(2011) Javier Vicario et al.   TETRAHEDRON LETTERS

Tandem Michael Addition/Aldol Reaction of Allenic Ketones with Alkyl Vinyl Ketones: Versatile Synthesis of 2-Alkynyl 1,5-Diketones, 4-Alkynyl-3-hydroxycyclohexanones and 4-Alkynylcyclohexenones

(2010) Deepika Malhotra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Phosphonoxins III: Synthesis of α-Aminophosphonate Analogs of Antifungal Polyoxins with Anti-GiardiaActivity

(2010) Michael Staake et al.   ORGANIC LETTERS

α-Chiral Acetylenes Having an All-Carbon Quaternary Center: Phase Transfer Catalyzed Enantioselective α Alkylation of α-Alkyl-α-alkynyl Esters

(2009) Takuya Hashimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugated imines and iminium salts as versatile acceptors of nucleophiles

(2009) Makoto Shimizu et al.   CHEMICAL COMMUNICATIONS

TBAF-Mediated Aldol Reaction of β-Allenoates: Regio- and Stereoselective Synthesis of (2E,4E)-4-Carbinol Alkadienoates

(2009) José C. Aponte et al.   JOURNAL OF ORGANIC CHEMISTRY

Straightforward Stereoselective Access to Cyclic Peptidomimetics

(2009) Santos Fustero et al.   JOURNAL OF ORGANIC CHEMISTRY

anti-Aminoallylation of Aldehydes via Ruthenium-Catalyzed Transfer Hydrogenative Coupling of Sulfonamido Allenes: 1,2-Aminoalcohols

(2009) Eduardas Skucas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Hydrophosphonylation of Ketimines Using Cinchona Alkaloids

(2009) Shuichi Nakamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective, copper(I)-catalyzed three-component reaction for the synthesis of β,γ-alkynyl α-amino acid derivatives

(2009) Zhihui Shao et al.   TETRAHEDRON-ASYMMETRY

Catalytic Hydrogenation of α-Iminophosphonates as a Method for the Synthesis of Racemic and Optically Active α-Aminophosphonates

(2008) Nataliya S. Goulioukina et al.   ADVANCED SYNTHESIS & CATALYSIS

Organometal additions to α-iminoesters: N-alkylation via umpolung

(2008) Joshua S. Dickstein et al.   CHEMICAL SOCIETY REVIEWS

Preparation of α,α-Disubstituted α-Amino Acid Derivatives via Alkyl Addition to α-Oxime Esters with Organozinc Species

(2008) Michiharu Mitani et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective Pudovik Reaction of Aldehydes and Aldimines with Tethered Bis(8-quinolinato) (TBOx) Aluminum Complex

(2008) Joshua P. Abell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three Component Coupling of α-Iminoesters via Umpolung Addition of Organometals: Synthesis of α,α-Disubstituted α-Amino Acids

(2008) Joshua S. Dickstein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Alkylations of Ketoimines. Enantioselective Synthesis ofN-Substituted Quaternary Carbon Stereogenic Centers by Zr-Catalyzed Additions of Dialkylzinc Reagents to Aryl-, Alkyl-, and Trifluoroalkyl-Substituted Ketoimines

(2008) Peng Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Catalyzed 1,2-Shift of Diverse Migrating Groups in Allenyl Systems as a New Paradigm toward Densely Functionalized Heterocycles

(2008) Alexander S. Dudnik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ag-Catalyzed Diastereo- and Enantioselective Vinylogous Mannich Reactions of α-Ketoimine Esters. Development of a Method and Investigation of its Mechanism

(2008) Laura C. Wieland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Michael Addition of Allenoates to Electron-Deficient Olefins: Facile Synthesis of 2-Alkynyl-Substituted Glutaric Acid Derivatives

(2008) Le-Ping Liu et al.   ORGANIC LETTERS

Highly Regioselective Fluorination and Iodination of Alkynyl Enolates

(2008) Han Yang et al.   ORGANIC LETTERS

Synthesis of Functionalized α,α-Disubstituted β-Alkynyl Esters from Allenoates through an Alkynylenolate Intermediate

(2008) Weibo Wang et al.   ORGANIC LETTERS

A practical approach to non-natural or N-unsubstituted α-arylglycine derivatives: Hf(OTf)4-doped Me3SiCl system-catalyzed aminomethylation of electron-rich arenes with a new type of N,O-acetal

(2008) Norio Sakai et al.   TETRAHEDRON

Intramolecular alkynylogous Mukaiyama aldol type reaction mediated by TBSOTf/NEt3

(2008) Laurence Miesch et al.   TETRAHEDRON LETTERS

Convenient enantioselective synthesis of β-trifluoromethyl-β-aminoketones by organocatalytic asymmetric Mannich reaction of aryl trifluoromethyl ketimines with acetone

(2008) Volodymyr A. Sukach et al.   TETRAHEDRON-ASYMMETRY

Thermodynamically Favored Aldol Reaction of Propargyl or Allenyl Esters: Regioselective Synthesis of Carbinol Allenoates

(2007) Bo Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION