Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Challenges to curing primary brain tumours

(2019) Kenneth Aldape et al.   Nature Reviews Clinical Oncology

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Adaptive adhesion systems mediate glioma cell invasion in complex environments

(2018) Pavlo G. Gritsenko et al.   JOURNAL OF CELL SCIENCE

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Multidimensional communication in the microenvirons of glioblastoma

(2018) Marike L. Broekman et al.   Nature Reviews Neurology

Harmful networks in the brain and beyond

(2018) Frank Winkler et al.   SCIENCE

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

(2018) Johanna Klughammer et al.   NATURE MEDICINE

Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma

(2018) Tanja Eisemann et al.   NEURO-ONCOLOGY

Molecular markers in glioma

(2017) Kirsten Ludwig et al.   JOURNAL OF NEURO-ONCOLOGY

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

(2017) Qunfeng Wu et al.   MOLECULAR THERAPY

Multilineage communication regulates human liver bud development from pluripotency

(2017) J. Gray Camp et al.   NATURE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Human tissue engineering allows the identification of active miRNA regulators of glioblastoma aggressiveness

(2016) E. Cosset et al.   BIOMATERIALS

Intratumoral Heterogeneity of the Epigenome

(2016) Tali Mazor et al.   CANCER CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

(2015) Christina Dargel et al.   GASTROENTEROLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Unravelling tumour heterogeneity—implications for therapy

(2015) David A. Reardon et al.   Nature Reviews Clinical Oncology

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

Scalable and DiI-compatible optical clearance of the mammalian brain

(2015) Bing Hou et al.   Frontiers in Neuroanatomy

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

The relationship between brain tumor cell invasion of engineered neural tissues and in vivo features of glioblastoma

(2013) Zeynab Nayernia et al.   BIOMATERIALS

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary brain tumours in adults

(2012) Damien Ricard et al.   LANCET

Interstitial guidance of cancer invasion

(2011) Pavlo G. Gritsenko et al.   JOURNAL OF PATHOLOGY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway

(2008) Wei Cheng et al.   CARCINOGENESIS