Release of a disordered domain enhances HspB1 chaperone activity toward tau

Mechanisms of Small Heat Shock Proteins

(2019) Maria K. Janowska et al.   Cold Spring Harbor Perspectives in Biology

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

(2019) Miranda P. Collier et al.   Science Advances

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of 'quasi-ordered' states

(2019) Amanda F Clouser et al.   eLife

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

(2018) Hannah E. R. Baughman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3

(2018) Alice R. Clark et al.   JOURNAL OF MOLECULAR BIOLOGY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity

(2018) Sanjay Mishra et al.   STRUCTURE

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

(2018) Zhenying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

(2017) Nikolai N. Sluchanko et al.   STRUCTURE

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

Structure of the α-crystallin domain from the redox-sensitive chaperone, HSPB1

(2015) Ponni Rajagopal et al.   JOURNAL OF BIOMOLECULAR NMR

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

(2015) Ponni Rajagopal et al.   eLife

Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6

(2014) Stephen D. Weeks et al.   JOURNAL OF STRUCTURAL BIOLOGY

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated structural transitions unleash the chaperone activity of  B-crystallin

(2013) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of an Activated Variant of Small Heat Shock Protein Hsp16.5

(2012) Hassane S. Mchaourab et al.   BIOCHEMISTRY

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

(2012) Scott P Delbecq et al.   EMBO JOURNAL

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

N-terminal domain of  B-crystallin provides a conformational switch for multimerization and structural heterogeneity

(2011) S. Jehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple molecular architectures of the eye lens chaperone  B-crystallin elucidated by a triple hybrid approach

(2011) N. Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golgi Bypass: Skirting Around the Heart of Classical Secretion

(2011) A. G. Grieve et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone Function

(2009) David Hayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY