A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

(2019) Anna Moskovskich et al.   Scientific Reports

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma

(2019) Ning Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Periodic fasting starves cisplatin‐resistant cancers to death

(2018) Novella Guidi et al.   EMBO JOURNAL

Artesunate shows potent anti-tumor activity in B-cell lymphoma

(2018) Thea Kristin Våtsveen et al.   Journal of Hematology & Oncology

Increased Glutamine Consumption in Cisplatin-Resistant Cells Has a Negative Impact on Cell Growth

(2018) Guihua Duan et al.   Scientific Reports

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

(2018) Zhou Yu et al.   eLife

GeneGini: Assessment via the Gini Coefficient of Reference “Housekeeping” Genes and Diverse Human Transporter Expression Profiles

(2018) Steve O'Hagan et al.   Cell Systems

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum

(2018) Marie-Christine Klein et al.   Nature Communications

In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens

(2018) Adrián César-Razquin et al.   Frontiers in Pharmacology

LZTR1 is a regulator of RAS ubiquitination and signaling

(2018) Johannes W. Bigenzahn et al.   SCIENCE

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

(2017) Marco P Licciardello et al.   Nature Chemical Biology

A CRISPR screen identifies a pathway required for paraquat-induced cell death

(2017) Colleen R Reczek et al.   Nature Chemical Biology

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics

(2016) Margarida Estudante et al.   MedChemComm

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Quantifying the impact of transporters on cellular drug permeability

(2015) Pär Matsson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

(2015) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

Cisplatin Induces Cytotoxicity through the Mitogen-Activated Protein Kinase Pathways ana Activating Transcription Factor 3

(2015) Carly St. Germain et al.   NEOPLASIA

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

(2014) Nai-Di Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

E-CRISP: fast CRISPR target site identification

(2014) Florian Heigwer et al.   NATURE METHODS

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Profiling Solute Carrier Transporters in the Human Blood–Brain Barrier

(2013) E G Geier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Roles of the nucleotide sugar transporters (SLC35 family) in health and disease

(2013) Zhiwei Song   MOLECULAR ASPECTS OF MEDICINE

Mammalian iron transporters: Families SLC11 and SLC40

(2013) Nicolas Montalbetti et al.   MOLECULAR ASPECTS OF MEDICINE

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K

(2013) Hideyuki Motohashi et al.   MOLECULAR ASPECTS OF MEDICINE

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects

(2013) Helgi B. Schiöth et al.   MOLECULAR ASPECTS OF MEDICINE

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

(2012) Karin Lanthaler et al.   BMC BIOLOGY

Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis

(2012) Alan J. Robinson et al.   EXPERIMENTAL CELL RESEARCH

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

(2011) Rongbao Zhao et al.   Annual Review of Nutrition

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

(2011) J. H. Reiling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

SLC19A1 pharmacogenomics summary

(2010) Sook Wah Yee et al.   Pharmacogenetics and Genomics

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY