MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma

(2013) Céline Pinheiro et al.   DISEASE MARKERS

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

(2012) Ralph J. DeBerardinis et al.   CELL

3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity

(2012) Douglas Jardim-Messeder et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate

(2012) Odília Queirós et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase

(2012) Clara Rodrigues-Ferreira et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

(2012) Y. H. Ko et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae

(2012) Paweł Lis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

(2012) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

3-bromopyruvate: Targets and outcomes

(2012) Maria C. Shoshan   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson

(2012) Kıvanç Birsoy et al.   NATURE MEDICINE

Skeletal muscle transcriptional coactivator PGC-1  mediates mitochondrial, but not metabolic, changes during calorie restriction

(2012) L. W. S. Finley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells

(2011) Ulrich Elling et al.   Cell Stem Cell

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Identification of host cell factors required for intoxication through use of modified cholera toxin

(2011) Carla P. Guimaraes et al.   JOURNAL OF CELL BIOLOGY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma

(2010) Céline Pinheiro et al.   HISTOPATHOLOGY

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

(2009) Muthusamy Thangaraju et al.   CANCER

Targets of 3-Bromopyruvate, A New, Energy Depleting, Anticancer Agent

(2009) P. Dell'Antone   Medicinal Chemistry

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid

(2008) Marilyn E. Morris et al.   AAPS Journal

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1

(2008) Ana Paula Pereira Da Silva et al.   BIOCHEMICAL JOURNAL

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

(2008) T. E. Wood et al.   MOLECULAR CANCER THERAPEUTICS

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

(2008) Céline Pinheiro et al.   VIRCHOWS ARCHIV