An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts

Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity

(2019) Kohei Oishi et al.   Frontiers in Microbiology

The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression

(2019) Lea Gaucherand et al.   Cell Reports

PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection

(2019) Rachel E. Rigby et al.   Scientific Reports

PA-X: a key regulator of influenza A virus pathogenicity and host immune responses

(2018) Jiao Hu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X

(2018) Kohei Oishi et al.   Cell Reports

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

(2018) Chutikarn Chaimayo et al.   PLoS Pathogens

Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts

(2017) Khristine Kaith S. Lloren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular basis of mammalian transmissibility of avian H1N1 influenza viruses and their pandemic potential

(2017) Mark Zanin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

(2017) Jinhwa Lee et al.   VIROLOGY

Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection

(2017) Yousuke Fujimoto et al.   Scientific Reports

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

(2016) Yuhai Bi et al.   Cell Host & Microbe

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity

(2016) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

Comparing the functions of equine and canine influenza H3N8 virus PA-X proteins: Suppression of reporter gene expression and modulation of global host gene expression

(2016) Kurtis H. Feng et al.   VIROLOGY

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

(2016) Denys A. Khaperskyy et al.   PLoS Pathogens

Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs

(2016) Guanlong Xu et al.   Scientific Reports

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice

(2015) Yuhai Bi et al.   JOURNAL OF VIROLOGY

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

(2015) Kohei Oishi et al.   JOURNAL OF VIROLOGY

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

(2015) Jiao Hu et al.   JOURNAL OF VIROLOGY

Impact of influenza PA-X on host response

(2015) Tsuyoshi Hayashi et al.   Oncotarget

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses

(2015) Huijie Gao et al.   Scientific Reports

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus

(2014) Juan Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

(2014) Lunbiao Cui et al.   Nature Communications

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

(2014) Denys A. Khaperskyy et al.   PLoS Pathogens

Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses

(2014) Xuyong Li et al.   PLoS Pathogens

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Human infection with avian influenza A H7N9 virus: an assessment of clinical severity

(2013) Hongjie Yu et al.   LANCET

Biological features of novel avian influenza A (H7N9) virus

(2013) Jianfang Zhou et al.   NATURE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet

(2013) Y. Zhang et al.   SCIENCE

H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

(2013) Q. Zhang et al.   SCIENCE

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

Frameshifting to PA-X Influenza

(2012) J. W. Yewdell et al.   SCIENCE

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

(2011) J. B. Kimble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

(2011) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production

(2009) M. H. Hudy et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host

(2009) E. de Wit et al.   JOURNAL OF VIROLOGY

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens