Editorial Material
Urology & Nephrology
Raymond A. Geherty, Matthew A. Sparks
Summary: The study demonstrated the central importance of glycosylation to uromodulin function, and highlighted the impact of post-translational modification on its function. Through both in vitro and clinical analyses, the researchers observed the binding of uromodulin to UPEC, and identified D-mannose as a competitive inhibitor for this interaction.
KIDNEY INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Murtala Bello Abubakar, Dawoud Usman, Gaber El-Saber Batiha, Natalia Cruz-Martins, Ibrahim Malami, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Aliyu Muhammad, Siew Hua Gan, Aliyu Ibrahim Dabai, M. Alblihed, Arabinda Ghosh, Reem H. Badr, Devarajan Thangadurai, Mustapha Umar Imam
Summary: COVID-19 is a potentially fatal multisystemic infection caused by SARS-CoV-2, with a lack of cost-effective, safe, and readily available therapeutic options. Traditional herbs used in African and Asian regions may contribute to a lesser burden of the pandemic. Ethnomedicinal plants containing bioactive compounds could potentially mitigate COVID-19 by modulating ACE2 activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yue Hu, Lihuan Liu, Xifeng Lu
Summary: ACE2, a negative regulator of the renin-angiotensin system, is the receptor for SARS-CoV-2 and plays a crucial role in the pathophysiology of COVID-19. It is implicated in tissue injury, chronic conditions such as hypertension, diabetes, and cardiovascular disease, and may be a potential therapeutic target for COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Keiji Kuba, Tomokazu Yamaguchi, Josef M. Penninger
Summary: Seventeen years after the SARS epidemic, the emergence of the novel coronavirus SARS-CoV-2 has led to an unprecedented pandemic. ACE2 plays a crucial role in cell entry of SARS-CoV-2 and its high affinity to ACE2 results in increased infectivity and transmissibility. In addition to serving as the receptor for SARS-CoV-2, ACE2 also plays an important role in various aspects of COVID-19 pathogenesis and potential post-COVID-19 syndromes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mark C. Chappell
Summary: The current COVID-19 epidemic has had a significant health burden and has become the third leading cause of death in the United States. The virus binds to ACE2, a crucial enzyme in the renin-angiotensin system, leading to tissue infection and replication. This can result in reduced ACE2 activity and activation of the RAS, potentially exacerbating the inflammatory response and disease severity. Male patients and autoantibodies targeting components of the RAS may contribute to the greater severity of infection. This review critically evaluates the role of the activated RAS in COVID-19 and its potential impact on male patients.
CIRCULATION RESEARCH
(2023)
Article
Immunology
Ana Rodriguez-Perez, Carmen M. Labandeira, Maria A. Pedrosa, Rita Valenzuela, Juan A. Suarez-Quintanilla, Maria Cortes-Ayaso, Placido Mayan-Conesa, Jose L. Labandeira-Garcia
Summary: The study found that COVID-19 patients had higher levels of AA-AT1 and AA-ACE2, which were significantly associated with disease severity. Patients with mild disease had lower levels of autoantibodies than those with moderate or severe disease, with no significant differences between males and females.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Medicine, Research & Experimental
Henry Sackin
Summary: Preexisting hypertension is a known risk factor for severe COVID-19. Abnormal activation of RAS upregulates angiotensin II, contributing to severe manifestations of COVID-19. While RAS inhibitors have been associated with an increase in ACE2 receptors that facilitate cellular entry of the SARS-CoV-2 virus, current medical practice does not recommend curtailing RAS inhibitors. Hypotheses suggest that RAS inhibitors reduce the severity of COVID-19 by promoting ACE2-AT1R complex formation and hindering SARS-CoV-2 binding to ACE2, leading to protocols for reducing disease severity.
MEDICAL HYPOTHESES
(2021)
Article
Physiology
Licy L. Yanes Cardozo, Samar Rezq, Jacob E. Pruett, Damian G. Romero
Summary: COVID-19 is a global pandemic, with kidney involvement being a key feature. Research suggests that androgens may predispose male patients to higher mortality by influencing kidney function during SARS-CoV-2 infection.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Luca Rossi, Alessandro Malagoli, Andrea Biagi, Alessia Zanni, Concetta Sticozzi, Greta Comastri, Luigi Pannone, Stefano Gandolfi, Pasquale Vergara, Giovanni Quinto Villani
Summary: The association of renin-angiotensin system inhibitors with the risk of death in patients with hypertension and COVID-19 is not well characterized. This study showed no independent association between ACEi or ARBs with mortality in patients with HTN and COVID-19, supporting the recommendation not to discontinue treatment with ACEIs or ARBs because of COVID-19.
Article
Physiology
Hamid Arazi, Akram Falahati, Katsuhiko Suzuki
Summary: The COVID-19 pandemic is caused by a novel coronavirus called SARS-CoV-2, and increasing ACE2 levels through physical exercise can improve outcomes. Exercise can activate anti-inflammatory responses and may serve as a potential therapeutic strategy against COVID-19.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Chan Tran N. Nguyen, Karen M. Kim, Bo Yang, Gorav Ailawadi, Himanshu J. Patel, G. Michael Deeb
Summary: Despite the rapid adoption of transcatheter aortic valve replacement (TAVR), there are limited data on aortic valve reintervention after initial TAVR. A retrospective study reviewed 1487 patients who underwent TAVR and found that 24 (1.6%) required aortic valve reintervention. Most patients were deemed unsuitable for repeat TAVR due to concurrent cardiac procedures, unfavorable anatomy, or endocarditis. Therefore, careful assessment of TAVR repeatability should be considered in the initial TAVR evaluation, especially for younger patients who may require aortic valve reintervention.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Physiology
Shah-Abas Muhamad, Azizah Ugusman, Jaya Kumar, Dominik Skiba, Adila A. Hamid, Amilia Aminuddin
Summary: Observational studies globally have shown that most COVID-19 patients have preexisting hypertension, raising questions about the potential relationship between COVID-19 and hypertension. This review summarizes the current understanding of the link between hypertension and COVID-19, as well as its underlying mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Lorenzo Braghieri, Simrat Kaur, Christopher K. Black, Paul C. Cremer, Shinya Unai, Samir R. Kapadia, Amgad Mentias
Summary: Transcatheter aortic valve replacement (TAVR) is increasingly used as the main treatment for aortic stenosis compared to surgical aortic valve replacement (SAVR). However, TAVR-related infective endocarditis (TAVR-IE) is expected to be more common in younger patients. Therefore, it is important for clinicians to be familiar with common presentations, major risk factors, diagnostic pitfalls, therapeutic approaches, and prevention of TAVR-IE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Plaza Martin, Gemma Pastor Baez, Alfredo Garcia Cabello, Alexander Stepanenko, Jose Alberto San Roman Calvar, Aitor Uribarri Gonzalez
Summary: Propofol infusion syndrome (PRIS) is a rare but serious condition that can cause cardiogenic shock. Mitochondrial toxicity and sympathetic blockade are the mechanisms leading to cardiogenic shock in PRIS. Diagnosis and treatment of PRIS can be challenging, and further examinations such as muscle biopsy and fat enzyme analysis are helpful in confirming the diagnosis. Withdrawal of propofol and supportive therapies, such as VA-ECMO, are the preferred treatment for severe PRIS, which can increase survival rate by serving as a bridge to recovery.
Article
Cardiac & Cardiovascular Systems
Chi-Hion Pedro Li, Rodrigo Estevez-Loureiro, Xavier Freixa, Rui Teles, Ana I. Molina-Ramos, Manuel Pan, Luis Nombela-Franco, Bruno Melica, Ignacio J. Amat-Santos, Ignacio Cruz-Gonzalez, Lluis Asmarats, Robert Alarcon, Laura Sanchis, Estefania Fernandez-Peregrina, Jose Antonio Baz, Xavier Millan, Irene Menduina, Dabit Arzamendi
Summary: The PASCAL system is a novel device for transcatheter mitral valve repair, and this study aimed to report the early clinical experience in Spain and Portugal. The results showed that transcatheter mitral valve repair with the PASCAL system was safe and effective, with high procedural success and low rates of adverse events. At 30 days, there was a significant improvement in mitral regurgitation and functional status.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Lilian Grigorian-Shamagian, Juan Francisco Oteo, Alejandro Gutierrez-Barrios, Omar Abdul-Jawad Altisent, Ignacio Amat-Santos, Agustin Fernandez Cisnal, Jessica Roa, Carlos Arellano Serrano, Edgar Fadeuilhe, Carlos Cortes, Ricardo Sanz-Ruiz, Maria Eugenia Vazquez-Alvarez, Felipe Diez Delhoyo, Maria Tamargo, Javier Soriano, Jaime Elizaga, Francisco Fernandez-Aviles, Enrique Gutierrez
Summary: This study evaluated the prevalence and clinical profile of endothelial dysfunction in patients with INOCA in Spain, as well as the predictors and prognostic impact of endothelial dysfunction. The results showed that approximately 45% of patients had endothelial dysfunction, which was associated with worsening symptoms and increased rates of adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Raquel Toribio-Fernandez, Carlos Ceron, Catarina Tristao-Pereira, Irene Fernandez-Nueda, Ana Perez-Castillo, Jose Fernandez-Ferro, Maria Angeles Moro, Borja Ibanez, Valentin Fuster, Marta Cortes-Canteli
Summary: Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated, with similar risk factors and vascular components. Clinical studies suggest that anticoagulants, particularly direct oral anticoagulants, may decrease the incidence of dementia in patients with CVD. However, more research is needed to understand the differential effects on different types of dementia and determine the best drug and strategy for prevention and treatment of AD.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
J. J. Coughlan, Borja Ibanez
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Oriol Rodriguez-Leor, Beatriz Toledano, Ramon Lopez-Palop, Fernando Rivero, Salvatore Brugaletta, Jose Antonio Linares, Tomas Benito, Pilar Carrillo, Marti Puigfel, German Cediel, Mario Sadaba, Beatriz Vaquerizo, Juan Rondan, Ivan Gomez, Fernando Alfonso, Roberto Saez, Ana Planas, Fernando Lozano, Felipe Hernandez, Manel Sabate, Jose Ramoen Ruiz-Arroyo, Francisco Torres, Jose Maria de la Torre Hernandez, Enrique Gutierrez, Ana Belen Cid-Alvarez, Jose Luis Diez, Luis Fernandez, Jose Moreu, Soledad Ojeda, Pablo Cerrato, Valeriano Ruiz-Quevedo, Juan Sanchis, Antonio Gomez-Menchero, Raymundo Ocaranza, Mohsen Mohandes, Jose Maria Hernandez, Miren Maite Alfageme, Pablo Aguiar, Jose Ramon Lopez Minguez, Armando Perez de Prado
Summary: Using intracoronary pressure wire in patients with intermediate coronary artery stenosis can lead to changes in diagnosis, treatment strategy, and clinical outcomes. This study highlights the importance of intracoronary pressure wire in guiding revascularization in coronary artery disease patients.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ines Garcia-Lunar, Borja Ibanez, Valentin Fuster
Summary: This commentary discusses the effects of a comprehensive lifestyle intervention on cardiovascular health in the TANSNIPPESA trial, and also refers to the discussion piece by Naslund et al. which suggests that the trial is not the end of the story.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Roberto Gomez-Sanchez, Jorge Garcia-Carreno, Jorge Martinez-Solano, Iago Sousa-Casasnovas, Miriam Juarez-Fernandez, Carolina Devesa-Cordero, Ricardo Sanz-Ruiz, Enrique Gutierrez-Ibanes, Jaime Elizaga, Francisco Fernandez-Aviles, Manuel Martinez-Selles
Summary: This study compared off-hours vs. regular-hours peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock patients. The results showed no significant differences in in-hospital mortality, 90-day mortality, length of hospital stay, and VA-ECMO related complications between off-hours and regular hours.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Estefania Fernandez-Peregrina, Luis Asmarats, Rodrigo Estevez-Loureiro, Isaac Pascual, Diana Bastidas, Tomas Benito-Gonzalez, Berenice Caneiro-Queija, Pablo Avanzas, Jose Alberto De Agustin, Felipe Fernandez-Vazquez, Manuel Barreiro-Perez, Victor Leon, Luis Nombela-Franco, Carmen Garrote, Chi-Hion Li, Jose Antonio Baz, Antonio Adeba, Jordi Sans-Rosello, Javier Gualis, Dabit Arzamendi
Summary: This study aimed to evaluate the prognostic value of myocardial strain (LVGLS) in patients with severely depressed left ventricular ejection fraction (LVEF) who underwent mitral transcatheter edge-to-edge valve repair with MitraClip. The results showed that regardless of LVEF, MitraClip was safe and improved the mid-term functional class of patients, and LVGLS can be used to select optimal candidates and predict worse prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lluis Asmarats, Lola Gutierrez-Alonso, Luis Nombela-Franco, Ander Regueiro, Xavier Millan, Gabriela Tirado-Conte, Pedro Cepas, Chi Hion Pedro Li, Estefania Fernandez-Peregrina, Pilar Jimenez-Quevedo, Xavier Freixa, Dabit Arzamendi
Summary: This study aimed to investigate the use of the cusp overlap technique (COT) during Portico implantation. The results showed that COT resulted in a higher valve implantation depth and lower rates of conduction disturbances (CD).
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Ignacio J. Amat-Santos, Mario Garcia-Gomez, Federico de Marco, Kim Won-Keun, Joao Brito, Jonathan Halim, John Jose, Gunasekaran Sengotuvelu, Ashok Seth, Christian Terkelsen, Marcin Protasiewicz, Nelson Bonilla, Bruno Garcia, Juan Pablo Sanchez-Luna, Sara Blasco-Turrion, Jose Carlos Gonzalez, Esther Gonzalez-Bartol, Alexander J. J. Ijsselmuiden, Itziar Gomez-Salvador, Manuel Carrasco Moraleja, Alberto San Roman
Summary: This study compared the efficacy of the latest generation of balloon-expandable and self-expandable transcatheter heart valves for the treatment of bicuspid aortic valve stenosis. The results showed that Myval had significantly higher device success rate at 30 days compared to S3U and EP+, with Myval having better aortic gradients and lower residual aortic regurgitation.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Review
Cardiac & Cardiovascular Systems
Jose Luis Zamorano, Clare Appleby, Hakim Benamer, Lutz Frankenstein, Giuseppe Musumeci, Luis Nombela-Franco
Summary: Transcatheter aortic valve implantation (TAVI) is recommended for severe aortic stenosis patients according to the ESC/EACTS 2021 Guidelines update. However, the implementation of guideline programs and addressing key challenges are necessary to ensure TAVI accessibility and capacity across Europe. The recommendations focus on improving procedural efficiency, optimizing patient pathways, and increasing collaboration and education among cardiology centers to enhance TAVI outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Holzamer, Francesco Bedogni, Pieter van Wyk, Parag Barwad, Marcin Protasiewicz, Alfonso Ielasi, Luis Nombela-Franco, Tim Seidler, Michael Hilker
Summary: This study summarized the initial worldwide experience with the Myval 32 mm device for the treatment of extremely large aortic valve anatomy. The device showed promising results with successful implantation and minimal complications. It is important for future transcatheter aortic valve replacement systems to accommodate larger anatomy.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, General & Internal
Teresa Sevilla, Noemi Ramos, Manuel Carnero, Ignacio J. Amat-Santos, Manuel Carrasco-Moraleja, Ana Revilla, Isidre Vilacosta, J. Alberto San Roman
Summary: There are differences between men and women in the pathophysiology and clinical manifestations of aortic stenosis (AS). Women undergo aortic valve intervention (AVI) at a later stage than men, resulting in a higher frequency of heart failure readmissions during the follow-up period, but overall mortality is not increased.
JOURNAL OF CLINICAL MEDICINE
(2023)