Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ferroptosis Contributes to Isoflurane Neurotoxicity

(2019) Yimeng Xia et al.   Frontiers in Molecular Neuroscience

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling

(2019) Wenbin Wan et al.   Frontiers in Neurology

Mitoferrin-1 is Involved in the Progression of Alzheimer’s Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer’s Disease

(2018) Jiatao Huang et al.   NEUROSCIENCE

Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts

(2018) Huihui Li et al.   Scientific Reports

Postoperative Delirium, Learning, and Anesthetic Neurotoxicity: Some Perspectives and Directions

(2018) W. Alan C. Mutch et al.   Frontiers in Neurology

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Metabolic control of ferroptosis in cancer

(2018) Michael P. Murphy   NATURE CELL BIOLOGY

Anesthesia and the developing brain: A way forward for laboratory and clinical research

(2018) Nicola Disma et al.   PEDIATRIC ANESTHESIA

Non-transferrin-bound iron transporters

(2018) Mitchell D. Knutson   FREE RADICAL BIOLOGY AND MEDICINE

Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity

(2017) Jennifer L. Walters et al.   NEUROTOXICOLOGY AND TERATOLOGY

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

(2017) Jing Wu et al.   Frontiers in Cellular Neuroscience

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice

(2016) Jing Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction

(2016) Yuping Li et al.   Journal of Neuroinflammation

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

(2016) Jirapas Sripetchwandee et al.   NEUROSCIENCE

Reactive Oxygen Species-mediated Loss of Phenotype of Parvalbumin Interneurons Contributes to Long-term Cognitive Impairments After Repeated Neonatal Ketamine Exposures

(2016) Hui Zhang et al.   NEUROTOXICITY RESEARCH

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Mitochondria and Iron: current questions

(2016) Bibbin T. Paul et al.   Expert Review of Hematology

Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

(2016) George J. Kontoghiorghes et al.   Drug Design Development and Therapy

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

(2016) Rachel S. White et al.   Molecular Brain

PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation

(2015) Yong Chen et al.   FEBS LETTERS

Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons

(2015) Barbara Sinner et al.   TOXICOLOGY

Iron entry in neurons and astrocytes: a link with synaptic activity

(2015) Franca Codazzi et al.   Frontiers in Molecular Neuroscience

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice

(2015) Jing Wu et al.   PLoS One

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

(2013) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum

(2013) Rainer Haseneder et al.   PLoS One

Anesthesia and tau pathology

(2013) Robert A. Whittington et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Surgical Trauma Induces Iron Accumulation and Oxidative Stress in a Rodent Model of Postoperative Cognitive Dysfunction

(2012) Li-Na An et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Association between neonatal iron overload and early human brain development in premature infants

(2012) Sanjiv B. Amin et al.   EARLY HUMAN DEVELOPMENT

Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture

(2012) Fang Liu et al.   TOXICOLOGICAL SCIENCES

Isolation and Culture of Hippocampal Neurons from Prenatal Mice

(2012) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)

(2011) Jay A. Cadieux et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Are anaesthetics toxic to the brain?

(2011) A.E. Hudson et al.   BRITISH JOURNAL OF ANAESTHESIA

Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

(2010) Ilaria Pelizzoni et al.   AGING CELL

Anesthesia and Postoperative Cognitive Dysfunction (POCD)

(2010) Bettina Jungwirth et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Oral Iron Chelators

(2009) Maria Domenica Cappellini et al.   Annual Review of Medicine

Mitochondrial iron accumulation with age and functional consequences

(2008) Arnold Y.  Seo et al.   AGING CELL