Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

AIF-regulated oxidative phosphorylation supports lung cancer development

(2019) Shuan Rao et al.   CELL RESEARCH

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

(2019) Yun Pyo Kang et al.   eLife

Structure and mechanism of mitochondrial proton-translocating transhydrogenase

(2019) Domen Kampjut et al.   NATURE

The redox requirements of proliferating mammalian cells

(2018) Aaron M. Hosios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute loss of iron–sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells

(2018) Daniel R. Crooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer

(2018) Shuai Li et al.   Redox Biology

Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet

(2018) Annelise Francisco et al.   JOURNAL OF NEUROCHEMISTRY

Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice

(2017) Claudia D.C. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice

(2017) E Meimaridou et al.   JOURNAL OF ENDOCRINOLOGY

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

(2017) Hung-Yao Ho et al.   Redox Biology

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

NNTmutations: a cause of primary adrenal insufficiency, oxidative stress and extra-adrenal defects

(2016) Florence Roucher-Boulez et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria

(2016) Juliana Aparecida Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

(2016) Mahesh S. Padanad et al.   Cell Reports

Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit

(2015) Kelsey H. Fisher-Wellman et al.   BIOCHEMICAL JOURNAL

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Iron–Sulfur Clusters as Biological Sensors: The Chemistry of Reactions with Molecular Oxygen and Nitric Oxide

(2014) Jason C. Crack et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nicotinamide Nucleotide Transhydrogenase (Nnt) Links the Substrate Requirement in Brain Mitochondria for Hydrogen Peroxide Removal to the Thioredoxin/Peroxiredoxin (Trx/Prx) System

(2014) Pamela Lopert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

(2014) Holger Webert et al.   Nature Communications

Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth, Induces Differentiation and Impacts PI3K/AKT Signaling

(2014) Jian-Guo Ren et al.   Scientific Reports

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Does Scavenging of Mitochondrial Superoxide Attenuate Cancer Prosurvival Signaling Pathways?

(2013) Rafal R. Nazarewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload

(2013) Kelsey H. Fisher-Wellman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

(2013) Paulo A. Gameiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin 1 Is Inactivated Due to Oxidation Induced by Peroxiredoxin under Oxidative Stress and Reactivated by the Glutaredoxin System

(2013) Yatao Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalase Abrogates  -Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers

(2013) E. A. Bey et al.   MOLECULAR CANCER THERAPEUTICS

Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells

(2013) Bryan C Dickinson et al.   Nature Protocols

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Effects of NADH kinase on NADPH-dependent biotransformation processes in Escherichia coli

(2012) Won-Heong Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

(2012) X. Huang et al.   CANCER RESEARCH

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

(2012) Alawiah Alhebshi et al.   MOLECULAR BIOLOGY OF THE CELL

The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2

(2012) Stefanie J. Navarro et al.   G3-Genes Genomes Genetics

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Mitochondrial NADH Kinase, Pos5p, Is Required for Efficient Iron-Sulfur Cluster Biogenesis inSaccharomyces cerevisiae

(2010) Jayashree Pain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins

(2009) Andrew G. Cox et al.   BIOCHEMICAL JOURNAL

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

(2008) Roland Lill et al.   Annual Review of Biochemistry

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH