Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

The C-Terminal Zinc Fingers of ZBTB38 are Novel Selective Readers of DNA Methylation

(2018) Amir Pozner et al.   JOURNAL OF MOLECULAR BIOLOGY

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

(2018) Quirin Hammer et al.   NATURE IMMUNOLOGY

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells

(2018) Alexander Rölle et al.   Cell Reports

Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis

(2018) Michäel Duruisseaux et al.   Lancet Respiratory Medicine

SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells

(2017) Tom L. Stephen et al.   IMMUNITY

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+T cells

(2017) Arnaud Delpoux et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

(2016) Lisa L. Liu et al.   Cell Reports

HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire

(2015) Nina Lauterbach et al.   HUMAN IMMUNOLOGY

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8+ T Cells in Response to a Lethal Poxvirus Infection

(2015) Aaron S. Rapaport et al.   IMMUNITY

Antigen-specific NK cell memory in rhesus macaques

(2015) R Keith Reeves et al.   NATURE IMMUNOLOGY

Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers

(2015) Ewelina Krzywinska et al.   EBioMedicine

Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation

(2014) V. D. Kheav et al.   HAEMATOLOGICA

Cutting Edge: NKG2ChiCD57+ NK Cells Respond Specifically to Acute Infection with Cytomegalovirus and Not Epstein-Barr Virus

(2014) D. W. Hendricks et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

(2014) Merlin Luetke-Eversloh et al.   PLoS Pathogens

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

Natural killer cell deficiency

(2013) Jordan S. Orange   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PD-1 Expression on Peripheral Blood Cells Increases with Stage in Renal Cell Carcinoma Patients and Is Rapidly Reduced after Surgical Tumor Resection

(2013) A. W. MacFarlane et al.   Cancer Immunology Research

Molecular definition of the identity and activation of natural killer cells

(2012) Natalie A Bezman et al.   NATURE IMMUNOLOGY

Genital HSV-2 Infection Induces Short-Term NK Cell Memory

(2012) Mohamed F. Abdul-Careem et al.   PLoS One

CCR2 Defines a Distinct Population of NK Cells and Mediates Their Migration during Influenza Virus Infection in Mice

(2012) Mary J. G. van Helden et al.   PLoS One

Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function

(2011) B. Foley et al.   BLOOD

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

(2011) S. Platonova et al.   CANCER RESEARCH

Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD

(2011) Silke Wiesmayr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells

(2011) Ben Youngblood et al.   IMMUNITY

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells

(2011) Xiaoming Feng et al.   NATURE IMMUNOLOGY

Characterization of Natural Killer Cell Phenotype and Function during Recurrent Human HSV-2 Infection

(2011) Niklas K. Björkström et al.   PLoS One

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

(2011) S. Lopez-Verges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion

(2010) Margareta P. Correia et al.   IMMUNOBIOLOGY

An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells

(2010) Louise M D'Cruz et al.   NATURE IMMUNOLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD56 negative NK cells: origin, function, and role in chronic viral disease

(2010) Niklas K. Björkström et al.   TRENDS IN IMMUNOLOGY

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development

(2009) X. Feng et al.   BLOOD

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses

(2009) Alison Crawford et al.   CURRENT OPINION IN IMMUNOLOGY

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E

(2008) C. Sinzger et al.   JOURNAL OF GENERAL VIROLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY