Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Myeloid cell plasticity in the evolution of central nervous system autoimmunity

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Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity

(2018) Prasant Kumar Jena et al.   FASEB JOURNAL

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Multiple Sclerosis

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Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course

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Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

(2018) Siamak MahmoudianDehkordi et al.   Alzheimers & Dementia

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells

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RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism

(2017) Elizabeth J. Tarling et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of FXR pathway does not alter glial cell function

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Neurotoxic reactive astrocytes are induced by activated microglia

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Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

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The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion

(2016) Stephanie Hucke et al.   ACTA NEUROPATHOLOGICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy

(2016) Nathalie Launay et al.   ACTA NEUROPATHOLOGICA

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

Effects of bile acids on neurological function and disease

(2016) Matthew McMillin et al.   FASEB JOURNAL

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Metabolomics in multiple sclerosis

(2016) Pavan Bhargava et al.   Multiple Sclerosis Journal

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis

(2016) Peggy P. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Metabolomics in multiple sclerosis

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An ImmunoChip study of multiple sclerosis risk in African Americans

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Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

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Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

UDCA exerts beneficial effect on mitochondrial dysfunction inLRRK2G2019Scarriers and in vivo

(2015) Heather Mortiboys et al.   NEUROLOGY

Gut Microbiome and Multiple Sclerosis

(2014) Pavan Bhargava et al.   Current Neurology and Neuroscience Reports

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis

(2014) A. M. Dickens et al.   NEUROLOGY

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

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Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

(2014) Alberto Ascherio et al.   JAMA Neurology

Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells

(2013) Taiki Kida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolomic markers reveal novel pathways of ageing and early development in human populations

(2013) Cristina Menni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

(2013) J.M. Gaspar et al.   NEUROSCIENCE

Pathway-based personalized analysis of cancer

(2013) Y. Drier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Polygenic Susceptibility to Multiple Sclerosis—The Shape of Things to Come

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Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

(2010) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Inflammation Impairs Reverse Cholesterol Transport In Vivo

(2009) Fiona C. McGillicuddy et al.   CIRCULATION

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA