HOTAIR/miR‐125 axis‐mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

(2019) Jianan Chen et al.   Molecular Cancer

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

(2019) Jinguan Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of cyclin E1 overcomes temozolomide resistance in glioblastoma by Mcl‐1 degradation

(2019) Huaxin Liang et al.   MOLECULAR CARCINOGENESIS

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016

(2019) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Linc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b

(2018) Chengchuang Song et al.   Epigenetics

Knockdown of LncRNA-UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA-125a/hexokinase 2 pathway

(2018) Yuan Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

(2018) Sze Kiat Tan et al.   Molecular Cancer

The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

(2018) Ana Xavier-Magalhães et al.   Oncotarget

The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation

(2018) Hongyan Tian et al.   RENAL FAILURE

HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression

(2017) Jian Ma et al.   Oncotarget

miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma

(2017) Zhanwei Sun et al.   Cell and Bioscience

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

(2016) Marybeth Anderson et al.   Oncotarget

Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo

(2015) Mao-Bin Meng et al.   CANCER LETTERS

Erratum: Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2015) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity

(2015) Dongshi Chen et al.   Oncotarget

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE