Article
Medicine, Research & Experimental
Yumin Zhu, Siqi Wang, Xiaochen Xi, Minfeng Zhang, Xiaofan Liu, Weina Tang, Peng Cai, Shaozhen Xing, Pengfei Bao, Yunfan Jin, Weihao Zhao, Yinghui Chen, Huanan Zhao, Xiaodong Jia, Shanshan Lu, Yinying Lu, Lei Chen, Jianhua Yin, Zhi John Lu
Summary: The study utilized sequencing technologies to detect different types of cancer-related RNA variations in plasma, revealing pathways associated with tumorigenesis and metastasis, immune responses, and metabolism. A 3-RNA detection panel for liver cancer was identified, showing promise for detecting AFP-negative and early-stage patients.
Article
Cell Biology
Hossein Sadeghi, Ehsan Nazemalhosseini-Mojarad, Unes Sahebi, Elnaz Fazeli, Ghasem Azizi-Tabesh, Vahid R. Yassaee, Sanaz Savabkar, Hamid Asadzadeh Aghdaei, Mohammad R. Zali, Reza Mirfakhraie
Summary: Vitamin D treatment modulates the expression of CYP24A1, PFDN4, and certain lncRNAs in colorectal cancer cells, which show potential as diagnostic biomarkers for colorectal cancer. The study suggests a cell-specific regulation of gene expression by vitamin D.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Patrick A. DeSouza, Xuan Qu, Hao Chen, Bhuvic Patel, Christopher A. Maher, Albert H. Kim
Summary: Developing effective therapies for GBM is challenging due to tumor heterogeneity and therapeutic resistance. Understanding the mechanisms and impact of long noncoding RNAs is crucial for improving management and outcomes in this aggressive brain cancer.
Review
Oncology
Xue Han, Shitai Zhang
Summary: Long non-coding RNAs (lncRNAs) are a type of RNA that do not code for proteins but have important regulatory functions. They play crucial roles in both the nucleus and cytoplasm, regulating various biological processes, especially in tumor development. LINC00641, a differentially expressed lncRNA in multiple tumors, has the potential to serve as a valuable biomarker and therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Lingfeng Li, Xu Zhang, Nian Liu, Xiang Chen, Cong Peng
Summary: LINC00473, an oncogenic lncRNA, is upregulated in various human malignancies and associated with poor clinical outcomes. Its overexpression can promote cell proliferation, migration, and invasion, suggesting it as a potential prognostic biomarker and therapeutic target for human cancers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Rongchuan Zhao, Xiaohan Sa, Nan Ouyang, Hong Zhang, Jiao Yang, Jinlin Pan, Jinhui Gu, Yuanshuai Zhou
Summary: The analysis identified common prognostic LncRNAs among different cancers, providing insights into cancer pathogenesis and potential novel drug targets in specific cancers like GBM.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Menggang Zhang, Fang Gao, Xiao Yu, Qiyao Zhang, Zongzong Sun, Yuting He, Wenzhi Guo
Summary: LINC00261, a recently discovered long intergenic non-protein coding RNA, is over-expressed in various human malignancies and functions as a tumor suppressor by regulating biological processes in cancer cells. Its up-regulation is closely correlated with favorable prognoses and clinical characteristics. This lncRNA shows promising prospects as both a biomarker and therapeutic target in tumor development.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Louis Delhaye, Edith De Bruycker, Pieter-Jan Volders, Daria Fijalkowska, Delphine De Sutter, Sven Degroeve, Lennart Martens, Pieter Mestdagh, Sven Eyckerman
Summary: Accumulating evidence has shown the importance of long non-coding RNAs (lncRNAs) in cellular homeostasis and their role in disease. This study combines two RNA-centric methods to identify the proteins that interact with HOTAIR, a well-known lncRNA associated with metastasis in cancer. The data sets reveal an association of HOTAIR with mitoribosomes, suggesting additional functions beyond its known transcriptional mode-of-action.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sina Dadafarin, Tomas C. Rodriguez, Michelle A. Carnazza, Raj K. Tiwari, Augustine Moscatello, Jan Geliebter
Summary: In this study, analysis of RNA-sequencing data revealed that MEG3 is highly associated with lymph node metastasis in thyroid cancer and may be a driver of aggressive disease.
Review
Biochemistry & Molecular Biology
Bela Goyal, Shashi Ranjan Mani Yadav, Nikee Awasthee, Sweety Gupta, Ajaikumar B. Kunnumakkara, Subash Chandra Gupta
Summary: MALAT1 is a widely studied lncRNA in cancer, playing an important role in tumorigenesis and development, localized in the periphery of nuclear speckles. Molecular tools have shown its diagnostic, prognostic, and therapeutic potential in various cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Cell Biology
Jiho Rhim, Woosun Baek, Yoona Seo, Jong Heon Kim
Summary: miR-21 plays a critical role in various cancers and has potential as a biomarker for cancer diagnosis and prognosis.
Retraction
Cell Biology
Xinggang Guo, Hongqi Xiao, Sihong Guo, Jing Li, Yuxia Wang, Jie Chen, Ge Lou
Summary: The article published on October 26, 2018, has been retracted due to flaws and inconsistencies between results presented and experimental methods described, rendering the conclusions invalid.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Clinical Neurology
Genaro Rodriguez Villa, Ennio Antonio Chiocca
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in various aspects of glioblastoma (GBM) pathophysiology, including proliferation, invasion, radiation and temozolomide resistance, and immune modulation. The tissue- and tumor-specific expression of most lncRNAs makes them attractive targets for therapeutic translation. Recent progress has greatly advanced our understanding of lncRNAs in GBM. In this review, we discuss the function of lncRNAs, specific lncRNAs that are critical in key aspects of GBM pathophysiology, and the potential clinical relevance of lncRNAs for GBM patients.
Review
Immunology
Saeedeh Salehi, Shima Afzali, Abbas Shahi, Ali Akbar Amirzargar, Yaser Mansoori
Summary: Organ transplantation is the preferred treatment for end-stage organ diseases, but allograft rejection remains a major obstacle to long-term survival. Long noncoding RNAs (lncRNAs) have been proposed as potential targets for prediction, prognosis, diagnosis, and treatment of graft rejection. Noninvasive predictive biomarkers hold promise to overcome the limitations of traditional tissue biopsy. This review provides a comprehensive overview of lncRNAs and their role in facilitating the diagnosis, prognosis, and prediction of graft rejection, and suggests therapeutic choices after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Ashish H. Shah, Ignacio Jusue-Torres, Michael E. Ivan, Ricardo J. Komotar, Noriyuki Kasahara
JOURNAL OF NEUROSURGERY
(2018)
Article
Clinical Neurology
Ashish H. Shah, Joshua D. Burks, Simon S. Buttrick, Luca Debs, Michael E. Ivan, Ricardo J. Komotar
Article
Engineering, Biomedical
Rakesh K. Pathak, Uttara Basu, Anis Ahmad, Shrita Sarkar, Anil Kumar, Bapurao Surnar, Saba Ansari, Katarzyna Wilczek, Michael E. Ivan, Brian Marples, Nagesh Kolishetti, Shanta Dhar
Article
Clinical Neurology
Andrew Roth, Simon S. Buttrick, Iahn Cajigas, Jonathan R. Jagid, Michael E. Ivan
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Ashish H. Shah, Manish Kuchakulla, George M. Ibrahim, Eesh Dadheech, Ricardo J. Komotar, Sakir H. Gultekin, Michael E. Ivan
WORLD NEUROSURGERY
(2019)
Review
Clinical Neurology
Joseph R. Linzey, Walavan Sivakumar, Jeremiah N. Johnson, Michael E. Ivan, Ali S. Haider, Chris Ann Philips, Khoi D. Than, Krystal L. Tomei, Karin M. Muraszko, Edjah K. Nduom
WORLD NEUROSURGERY
(2019)
Article
Immunology
Judith Sanchez-Ventura, Jesus Amo-Aparicio, Xavier Navarro, Clara Penas
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Multidisciplinary Sciences
Clara Penas, Marie E. Maloof, Vasileios Stathias, Jun Long, Sze Kiat Tan, Jose Mier, Yin Fang, Camilo Valdes, Jezabel Rodriguez-Blanco, Cheng-Ming Chiang, David J. Robbins, Daniel J. Liebl, Jae K. Lee, Mary E. Hatten, Jennifer Clarke, Nagi G. Ayad
NATURE COMMUNICATIONS
(2019)
Article
Clinical Neurology
Georgina Palomes-Borrajo, Jordi Badia, Xavier Navarro, Clara Penas
Summary: Neuropathic pain is a common disability caused by enhanced neuronal excitability after nervous system injury, requiring modifications of transcriptional programs. Inhibition of BET proteins may be a promising therapy for reducing neuropathic pain after neural injury.
Review
Oncology
Torin P. Thielhelm, Stefania Goncalves, Scott M. Welford, Eric A. Mellon, Erin R. Cohen, Aida Nourbakhsh, Cristina Fernandez-Valle, Fred Telischi, Michael E. Ivan, Christine T. Dinh
Summary: Vestibular schwannomas (VS) are tumors that originate from Schwann cells of the vestibulocochlear nerve, causing hearing loss and dizziness. Though radiation therapy is common, some tumors are radioresistant, necessitating additional treatment. Understanding VS radiobiology is crucial for improving treatment outcomes.
Article
Neurosciences
Aria M. Jamshidi, Ashish Shah, Daniel G. Eichberg, Ricardo J. Komotar, Michael Ivan
Summary: High-volume lumbar puncture followed by acetazolamide therapy can be considered as an effective treatment for managing iatrogenic CSF leaks, with a high cure rate and low complication rate.
Article
Neurosciences
Georgina Palomes-Borrajo, Xavier Navarro, Clara Penas
Summary: This study demonstrates that inhibiting BET proteins in macrophages can enhance axonal outgrowth and promote peripheral nerve regeneration. However, specific targeting of BET proteins to macrophages is needed for efficient functional recovery after nerve injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Correction
Immunology
Judith Sanchez-Ventura, Jesus Amo-Aparicio, Xavier Navarro, Clara Penas
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
J. Sanchez-Ventura, C. Canal, J. Hidalgo, C. Penas, X. Navarro, A. Torres-Espin, K. Fouad, E. Udina
Summary: This study aims to elucidate the role of spinal PNNs on motor function and plasticity. Lack of Crtl1 can lead to disorganized PNNs, altering excitatory synapses and affecting the physiological properties of motoneurons, resulting in motor impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Microbiology
Sauson Soldozy, Daniel G. Eichberg, Alexis A. Morell, Evan Luther, Victor M. Lu, Dominique M. O. Higgins, Nitesh V. Patel, Ashish H. Shah, Simon J. Hanft, Ricardo J. Komotar, Michael E. Ivan
Summary: The incidence of brain tumors, particularly glioblastoma, is increasing. Current treatments have limited success, highlighting the need for new strategies. Oncolytic virotherapy shows promise as a robust and effective treatment for brain tumors, with ongoing clinical trials for high-grade glioma. The unique properties of the nervous system and heterogeneity of brain tumors make oncolytic viruses a potential solution, with the ability for genetic modification and direct inoculation.