Manipulation of selective macroautophagy by pathogens at a glance

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

(2019) Subhash Mehto et al.   MOLECULAR CELL

How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication

(2019) Wolfgang Eisenreich et al.   Frontiers in Cellular and Infection Microbiology

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

(2019) Eleonora Turco et al.   MOLECULAR CELL

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

(2019) Huifang Xian et al.   Autophagy

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy and innate immunity: Insights from invertebrate model organisms

(2018) Cheng-Ju Kuo et al.   Autophagy

Controlling inflammation by selective autophagy

(2018) Junghyun Lim et al.   CELL DEATH AND DIFFERENTIATION

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol

(2018) Mandy I. Cheng et al.   CELLULAR MICROBIOLOGY

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit

(2018) Abigail K. Corona et al.   Cell Reports

CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation

(2018) Yasir Mohamud et al.   CELL DEATH AND DIFFERENTIATION

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy

(2017) Tristan X. Jordan et al.   JOURNAL OF VIROLOGY

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

(2017) Kohei Arasaki et al.   Nature Communications

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

(2017) Yu Zhang et al.   Nature Communications

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism

(2017) Aishwarya Sathyanarayan et al.   Cell Reports

TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

(2017) Qing Yang et al.   PLoS Pathogens

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

(2017) Aimin Yang et al.   eLife

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6

(2016) Stephanie T. Chan et al.   JOURNAL OF VIROLOGY

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

Mechanistic insights into selective autophagy pathways: lessons from yeast

(2016) Jean-Claude Farré et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions

(2016) Jacqueline M. Kimmey et al.   TRENDS IN MOLECULAR MEDICINE

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs

(2015) Florian A. Horenkamp et al.   DEVELOPMENTAL CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection

(2014) J Shi et al.   CELL DEATH AND DIFFERENTIATION

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling

(2013) Junyan Shi et al.   Autophagy

The chlamydial OTU domain-containing proteinChlaOTU is an early type III secretion effector targeting ubiquitin and NDP52

(2013) Ana Rita Furtado et al.   CELLULAR MICROBIOLOGY

Listeriaphospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures

(2013) Ivan Tattoli et al.   EMBO JOURNAL

Species-specific impact of the autophagy machinery on Chikungunya virus infection

(2013) Delphine Judith et al.   EMBO REPORTS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytosolic clearance of replication-deficient mutants revealsFrancisella tularensisinteractions with the autophagic pathway

(2012) Audrey Chong et al.   Autophagy

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

(2011) Megumi Inomata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p62 and NDP52 Proteins Target IntracytosolicShigellaandListeriato Different Autophagy Pathways

(2011) Serge Mostowy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy

(2009) Nicolas Dupont et al.   Cell Host & Microbe

Galectin-3, a marker for vacuole lysis by invasive pathogens

(2009) Irit Paz et al.   CELLULAR MICROBIOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Listeria monocytogenes ActA-mediated escape from autophagic recognition

(2009) Yuko Yoshikawa et al.   NATURE CELL BIOLOGY

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

Lipids in host–pathogen interactions: Pathogens exploit the complexity of the host cell lipidome

(2009) Ynske P.M. van der Meer-Janssen et al.   PROGRESS IN LIPID RESEARCH

The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum

(2008) Yoko Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

(2008) Christian Pohl et al.   NATURE CELL BIOLOGY