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Biochemistry & Molecular Biology
Felix Clemens Richter, Matthias Friedrich, Nadja Kampschulte, Klara Piletic, Ghada Alsaleh, Ramona Zummach, Julia Hecker, Mathilde Pohin, Nicholas Ilott, Irina Guschina, Sarah Karin Wideman, Errin Johnson, Mariana Borsa, Paula Hahn, Christophe Morriseau, Bruce D. Hammock, Henk Simon Schipper, Claire M. Edwards, Rudolf Zechner, Britta Siegmund, Carl Weidinger, Nils Helge Schebb, Fiona Powrie, Anna Katharina Simon
Summary: Lipids play a major role in inflammatory diseases through altering inflammatory cell functions. Autophagy, a lysosomal degradation pathway, is found to regulate lipid availability, which affects inflammation. Loss of autophagy gene Atg7 in adipocytes exacerbates intestinal inflammation by causing an imbalance of oxylipins, reducing IL-10 secretion, and exacerbating intestinal inflammation through the cytochrome P450-EPHX pathway.
Article
Cell Biology
Lingli Zhou, Huasong Zeng, Jun Cui, Shouheng Jin
Summary: Dysregulation of NOD2 signaling is associated with susceptibility to immunological and inflammatory diseases. Palmitoylation of NOD2 can modulate its stability and influence inflammation. A recently discovered variant enhances inflammation through increased palmitoylation and decreased autophagic degradation.
Article
Biochemistry & Molecular Biology
Manuela Morleo, Simona Brillante, Umberto Formisano, Luigi Ferrante, Fabrizia Carbone, Daniela Iaconis, Alessandro Palma, Viviana Buonomo, Angela Serena Maione, Paolo Grumati, Carmine Settembre, Brunella Franco
Summary: A negative feedback mechanism limiting autophagosome biogenesis by degrading ATG13 is discovered, with OFD1 acting as an autophagy receptor for ATG13. Mutations in the OFD1 gene may lead to excessive autophagy, implicating dysregulated autophagy in the pathogenesis of renal cystic disease in mammals.
Article
Plant Sciences
Xiaonan Zhang, Zeping Wang, Xiaoya Li, Jiye Chen, Zongliang Yu, Xin Li, Changxin Sun, Lanqing Hu, Min Wu, Longtao Liu
Summary: The study aimed to assess the efficacy of polydatin on inflammation, cell death, and autophagy in atherosclerosis. The results showed that polydatin can inhibit inflammation and promote autophagy, thereby exerting anti-atherosclerotic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Melina Overhoff, Frederik Tellkamp, Simon Hess, Marianna Tolve, Janine Tutas, Marcel Faerfers, Lotte Ickert, Milad Mohammadi, Elodie De Bruyckere, Emmanouela Kallergi, Andrea Delle Vedove, Vassiliki Nikoletopoulou, Brunhilde Wirth, Joerg Isensee, Tim Hucho, Dmytro Puchkov, Dirk Isbrandt, Marcus Krueger, Peter Kloppenburg, Natalia L. Kononenko
Summary: This research reveals a new role of autophagy in regulating PKA signaling at neuronal synapses. Loss of ATG5 leads to synaptic accumulation of PKA-R1, affecting AMPAR trafficking and excitatory neurotransmission, potentially causing seizures.
Review
Biochemistry & Molecular Biology
Xishuai Tong, Gengsheng Yu, Xiaohui Fu, Ruilong Song, Jianhong Gu, Zongping Liu
Summary: Osteoclastogenesis is regulated by endogenous and exogenous factors, and is closely related to autophagy, inflammation, and immunity. Studies on osteoclastogenesis induced by different regulatory aspects have provided new directions for osteoclast differentiation and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xiaowei Li, Tania M. Palhano Zanela, Eric S. Underbakke, Yan Zhao
Summary: This study introduces a method to precisely manipulate kinase phosphorylation using synthetic receptors, achieving selective phosphorylation of peptides. The inhibition can block the phosphorylation of specific sites while allowing phosphorylation at other sites, and the receptors can work individually or together to protect substrate sequences.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Pharmacology & Pharmacy
Zheng Tian, Xinan Zhang, Mingli Sun
Summary: OA is a common degenerative joint disease with no current clinical treatments available to stop or slow down its progression. Targeting autophagy-related pathways has been found to be crucial in maintaining cartilage homeostasis and treating OA. Phytochemicals derived from plant extracts show potential as complementary and alternative agents for OA treatment through modulating autophagy-related signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Subhash Mehto, Kautilya Kumar Jena, Rina Yadav, Swatismita Priyadarsini, Pallavi Samal, Sivaram Krishna, Kollori Dhar, Ashish Jain, Nishant Ranjan Chauhan, Krushna C. Murmu, Ramyasingh Bal, Rinku Sahu, Pundrik Jaiswal, Bhabani Sankar Sahoo, Srinivas Patnaik, Thomas A. Kufer, Tor Erik Rusten, Swati Chauhan, Punit Prasad, Santosh Chauhan
Summary: This study reveals a unique mechanism where bacterial infection induces the formation of endogenous RIPK2 oligomers (RIPosomes) that coat the bacteria to induce NF-kappa B response. Autophagy proteins IRGM and p62/SQSTM1 physically interact with NOD1/2, RIPK2 and RIPosomes to promote their selective autophagy and limit NF-kappa B activation. This study highlights the involvement of innate immune proteins and autophagy machinery in bacterial defense and immune homeostasis maintenance.
Article
Medicine, Research & Experimental
Yi Ying, Chun-bin Sun, Si-qi Zhang, Bo-jun Chen, Jing-ze Yu, Fei-yu Liu, Jing Wen, Jiong Hou, Si-si Han, Jin-yuan Yan, Zhong-shan Yang, Lei Xiong
Summary: ASIV, extracted from Astragalus membranaceus, shows significant anti-inflammatory effects on CSE-exposed cells by promoting autophagy and inhibiting the TLR4/NF-κB signaling pathway, thus alleviating inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Simeng Wang, Yilong Yang, Dan Luo, Lingling Zhai, Yinglong Bai, Wei Wei, Qi Sun, Lihong Jia
Summary: The study found that BPA can induce inflammatory response in the lungs, possibly through the TLR4/NF-kappa B signaling pathway and mTOR-mediated autophagy. Inhibition of autophagy can weaken the inflammatory response.
Editorial Material
Cell Biology
Jaejin Kim, Yeonghyeon Lee, Taerang Jeon, Mi-Sung Kim, Chanhee Kang
Summary: Autophagy plays a dual role in maintaining cellular homeostasis and promoting cellular senescence, with selective autophagy coordinating stress support networks in senescent cells. Targeting selective autophagy may provide new therapeutic strategies for disrupting the homeostatic state of senescent cells.
Article
Cell Biology
Rui Xiong, Ning Li, Lei Chen, Wei Wang, Bo Wang, Wenyang Jiang, Qing Geng
Summary: STING may prevent cardiac remodelling induced by pressure overload by inhibiting autophagy, which could be a promising therapeutic target in heart failure.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Qinghai Meng, Yu Li, Tingting Ji, Ying Chao, Jun Li, Yu Fu, Suyun Wang, Qi Chen, Wen Chen, Fuhua Huang, Youran Wang, Qichun Zhang, Xiaoliang Wang, Huimin Bian
Summary: The study found that post-menopausal women have decreased autophagy and ER alpha expression in the aortic endothelium, with increased inflammation and pyroptosis. Estrogen treatment can accelerate autophagy and improve cell pyroptosis in OVX ApoE-/- mice and Hcy-treated HUVECs. Estrogen prevents atherosclerosis by upregulating ERα expression and subsequently inducing autophagy to reduce inflammation and pyroptosis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Liangchun Yang, Fanghua Ye, Jiao Liu, Daniel J. Klionsky, Daolin Tang, Rui Kang
Summary: This study reveals that extracellular SQSTM1 acts as a mediator of acute pancreatitis (AP) by enhancing sensitivity to autophagy-dependent ferroptotic cell death. High levels of serum SQSTM1 are found in AP patients and mice. Administration of SQSTM1-neutralizing antibodies protects mice against experimental AP.