Roles of GPRC5 family proteins: focusing on GPRC5B and lipid-mediated signalling

The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts

(2019) Friedrich Alexander von Samson-Himmelstjerna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

The Role of Ceramides in Insulin Resistance

(2019) Emilia Sokolowska et al.   Frontiers in Endocrinology

Identifying the localization and exploring a functional role for Gprc5c in the kidney

(2018) Premraj Rajkumar et al.   FASEB JOURNAL

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning

(2018) Takamitsu Sano et al.   NEUROSCIENCE RESEARCH

Caveolin-1 prevents palmitate-induced NF-κB signaling by inhibiting GPRC5B-phosphorylation

(2018) Yeon-Jeong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

(2018) Alexander Greenhough et al.   EMBO Molecular Medicine

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex

(2016) Sang-Ho Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

(2016) Dominic Gosejacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

C16:0-Ceramide Signals Insulin Resistance

(2014) Timothy Hla et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Intercellular Transfer of GPRC5B via Exosomes Drives HGF-Mediated Outward Growth

(2014) Sang-Ho Kwon et al.   CURRENT BIOLOGY

Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder

(2013) Özgür Albayrak et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

(2013) N. Kurabayashi et al.   DEVELOPMENT

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Increased Oxidative Stress Impairs Adipose Tissue Function in Sphingomyelin Synthase 1 Null Mice

(2013) Masato Yano et al.   PLoS One

G protein-linked signaling pathways in bipolar and major depressive disorders

(2013) Hiroaki Tomita et al.   Frontiers in Genetics

GPRC5B Activates Obesity-Associated Inflammatory Signaling in Adipocytes

(2012) Y.-J. Kim et al.   Science Signaling

Comparative characterization of GPRC5B and GPRC5C LacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice

(2011) Takamitsu Sano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular evolution of a chordate specific family of G protein-coupled receptors

(2011) Stefan Kurtenbach et al.   BMC EVOLUTIONARY BIOLOGY

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

(2011) Susumu Mitsutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockout of the Tumor Suppressor Gene Gprc5a in Mice Leads to NF- B Activation in Airway Epithelium and Promotes Lung Inflammation and Tumorigenesis

(2010) J. Deng et al.   Cancer Prevention Research

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1

(2010) Eijiro Yamada et al.   Cell Metabolism

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: Loss of boss causes abnormal energy metabolism

(2008) A. Kohyama-Koganeya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA