Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

(2020) Hyeun Sung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genipin‐crosslinked decellularized annulus fibrosus hydrogels induces tissue‐specific differentiation of bone mesenchymal stem cells and intervertebral disc regeneration

(2020) Yizhong Peng et al.   Journal of Tissue Engineering and Regenerative Medicine

Comparative Analysis between Three Different Lumbar Decompression Techniques (Microscopic, Tubular, and Endoscopic) in Lumbar Canal and Lateral Recess Stenosis: Preliminary Report

(2019) Chul-Woo Lee et al.   Biomed Research International

Comparison of clinical outcomes following minimally invasive or lumbar endoscopic unilateral laminotomy for bilateral decompression

(2019) Lynn B. McGrath et al.   JOURNAL OF NEUROSURGERY-SPINE

Is biportal technique/endoscopic spinal surgery satisfactory for lumbar spinal stenosis patients?

(2019) Taewook Kang et al.   MEDICINE

Comparative analysis of three types of minimally invasive decompressive surgery for lumbar central stenosis: biportal endoscopy, uniportal endoscopy, and microsurgery

(2019) Dong Hwa Heo et al.   Neurosurgical Focus

Customised multiphasic nucleus/annulus scaffold for intervertebral disc repair/regeneration

(2019) A. Gloria et al.   CONNECTIVE TISSUE RESEARCH

Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group

(2019) Aaron J. Fields et al.   EUROPEAN SPINE JOURNAL

How I do it? Uniportal full endoscopic contralateral approach for lumbar foraminal stenosis with double crush syndrome

(2019) Pang Hung Wu et al.   ACTA NEUROCHIRURGICA

Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration

(2019) Zachary NaPier et al.   MEDICAL SCIENCE MONITOR

Morphology of intervertebral disc ruptures evaluated by vacuum phenomenon using multi-detector computed tomography: association with lumbar disc degeneration and canal stenosis

(2018) Koichiro Murata et al.   BMC MUSCULOSKELETAL DISORDERS

Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review

(2018) Prasanthi Sampara et al.   GENE THERAPY

Comparison of bilateral versus unilateral decompression incision of minimally invasive transforaminal lumbar interbody fusion in two-level degenerative lumbar diseases

(2018) Yongzhao Zhao et al.   INTERNATIONAL ORTHOPAEDICS

Efficacy and safety of full-endoscopic decompression via interlaminar approach for central or lateral recess spinal stenosis of the lumbar spine

(2018) Chang-Hyun Lee et al.   SPINE

Operative Approaches for Lumbar Disc Herniation: A Systematic Review and Multiple Treatment Meta-Analysis of Conventional and Minimally Invasive Surgeries

(2018) Mohammed Ali Alvi et al.   World Neurosurgery

Is Eighty the New Sixty? Outcomes and Complications after Lumbar Decompression Surgery in Elderly Patients over 80 Years of Age

(2018) Julia Gerhardt et al.   World Neurosurgery

Use of a life-size three-dimensional-printed spine model for pedicle screw instrumentation training

(2018) Hyun Jin Park et al.   Journal of Orthopaedic Surgery and Research

Treatment of Degenerative Lumbar Spondylolisthesis With Fusion or Decompression Alone Results in Similar Rates of Reoperation at 5 Years

(2018) John S. Vorhies et al.   Clinical Spine Surgery

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

(2018) Isma Liza Mohd Isa et al.   Science Advances

Biomaterials for intervertebral disc regeneration: Current status and looming challenges

(2018) Yong-Can Huang et al.   Journal of Tissue Engineering and Regenerative Medicine

Percutaneous ozone nucleolysis for lumbar disc herniation

(2018) Mohamed Ezeldin et al.   NEURORADIOLOGY

Transforaminal Epiduroscopic Basivertebral Nerve Laser Ablation for Chronic Low Back Pain Associated with Modic Changes: A Preliminary Open-Label Study

(2018) Hyeun Sung Kim et al.   Pain Research & Management

Autologous blood-derived products compared to corticosteroids for treatment of plantar fasciopathy

(2018) Yu-Jen Chen et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Efficacy of an ethyl alcohol gel in symptomatic disc herniation

(2018) Stefano Marcia et al.   EUROPEAN JOURNAL OF RADIOLOGY

The short-term efficacy and safety of artificial total disc replacement for selected patients with lumbar degenerative disc disease compared with anterior lumbar interbody fusion: A systematic review and meta-analysis

(2018) Xiaoping Mu et al.   PLoS One

Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward

(2018) Ashley Cooney et al.   Genes

Engineering a biomimetic integrated scaffold for intervertebral disc replacement

(2018) Lilong Du et al.   Materials Science & Engineering C-Materials for Biological Applications

Changes in perfusion and diffusion in the endplate regions of degenerating intervertebral discs: a DCE-MRI study

(2017) Volkan Emre Arpinar et al.   EUROPEAN SPINE JOURNAL

Separate the Sheep from the Goats

(2017) Sandra Reitmaier et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Quantitative MRI and spectroscopy of bone marrow

(2017) Dimitrios C. Karampinos et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Biomechanics of the human intervertebral disc: A review of testing techniques and results

(2017) N. Newell et al.   Journal of the Mechanical Behavior of Biomedical Materials

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

(2017) Christopher Centeno et al.   Journal of Translational Medicine

Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease

(2017) Kristin Comella et al.   Journal of Translational Medicine

Fully endoscopic interlaminar and transforaminal lumbar discectomy: Analysis of 47 complications encountered in a series of 835 patients

(2017) Ali Güven Yörükoğlu et al.   NEUROCIRUGIA

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

Clinical and radiological outcomes of spinal endoscopic discectomy–assisted oblique lumbar interbody fusion: preliminary results

(2017) Dong Hwa Heo et al.   Neurosurgical Focus

Fully endoscopic lumbar interbody fusion using a percutaneous unilateral biportal endoscopic technique: technical note and preliminary clinical results

(2017) Dong Hwa Heo et al.   Neurosurgical Focus

Challenges and Solutions for Lumbar Total Disc Replacement Implantation

(2017) Michael Janssen et al.   SPINE

Defining the Ideal Lumbar Total Disc Replacement Patient and Standard of Care

(2017) Matthew Gornet et al.   SPINE

Cell therapy for the degenerating intervertebral disc

(2017) Wei Tong et al.   Translational Research

Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells

(2017) David C. Noriega et al.   TRANSPLANTATION

Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study

(2017) Hemant Kumar et al.   Stem Cell Research & Therapy

Endoscope-Assisted Extreme-Lateral Interbody Fusion: Preliminary Experience and Technical Note

(2017) Claudio Schonauer et al.   World Neurosurgery

MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1

(2017) Weiming Li et al.   World Neurosurgery

Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis

(2017) Kim L. Bennell et al.   Current Rheumatology Reports

Transforaminal Epiduroscopic Laser Ablation of Sinuvertebral Nerve in Patients with Chronic Diskogenic Back Pain: Technical Note and Preliminary Result

(2017) Hyeun Kim et al.   Journal of Neurological Surgery Part A-Central European Neurosurgery

Cell therapy for intervertebral disc repair: Clinical perspective

(2017) Daisuke Sakai et al.   Journal of Orthopaedic Translation

A Minimally Invasive Treatment for Lumbar Disc Herniation: DiscoGel® Chemonucleolysis in Patients Unresponsive to Chemonucleolysis with Oxygen-Ozone

(2017) S. Stagni et al.   INTERVENTIONAL NEURORADIOLOGY

Correlation of pain, functional impairment, and health-related quality of life with radiological grading scales of lumbar degenerative disc disease

(2016) M.-V. Corniola et al.   ACTA NEUROCHIRURGICA

Progression of lumbar disc herniations over an eight-year period in a group of adult Danes from the general population – a longitudinal MRI study using quantitative measures

(2016) Per Kjaer et al.   BMC MUSCULOSKELETAL DISORDERS

Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration

(2016) J.J. Wong et al.   EUROPEAN JOURNAL OF PAIN

Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses

(2016) Fan Ding et al.   EUROPEAN SPINE JOURNAL

Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update

(2016) Michael Monfett et al.   INTERNATIONAL ORTHOPAEDICS

Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study

(2016) Christian Elabd et al.   Journal of Translational Medicine

Percutaneous Treatment of Herniated Lumbar Discs with Ozone: Investigation of the Mechanisms of Action

(2016) Kieran Murphy et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes

(2016) Gregory James et al.   SPINE

Bone morphogenetic protein-2 provokes interleukin-18-induced human intervertebral disc degeneration

(2016) S. Ye et al.   Bone & Joint Research

Cauda Equina Syndrome

(2016) Leo R. Spector et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications

(2015) John T. Martin et al.   Acta Biomaterialia

Serum levels of the pro-inflammatory interleukins 6 (IL-6) and -8 (IL-8) in patients with lumbar radicular pain due to disc herniation: A 12-month prospective study

(2015) Linda Margareth Pedersen et al.   BRAIN BEHAVIOR AND IMMUNITY

Incidence of Low Back Pain After Lumbar Discectomy for Herniated Disc and Its Effect on Patient-reported Outcomes

(2015) Scott L. Parker et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Running Exercise Alleviates Pain and Promotes Cell Proliferation in a Rat Model of Intervertebral Disc Degeneration

(2015) Shuo Luan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

What types of degenerative lumbar pathologies respond to nerve root injection? A retrospective review of six hundred and forty one cases

(2015) Masahiro Kanayama et al.   INTERNATIONAL ORTHOPAEDICS

Long-term Treatment Effects of Lumbar Arthrodeses in Degenerative Disk Disease

(2015) Andriy Noshchenko et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential

(2015) Kivanc Atesok et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Diffusion tensor imaging of lumbar spinal nerve in subjects with degenerative lumbar disorders

(2015) Yasuhiro Oikawa et al.   MAGNETIC RESONANCE IMAGING

Can specific loading through exercise impart healing or regeneration of the intervertebral disc?

(2015) James Steele et al.   Spine Journal

Intervertebral Disc Tissue Engineering with Natural Extracellular Matrix-Derived Biphasic Composite Scaffolds

(2015) Baoshan Xu et al.   PLoS One

Diffusion-Weighted MRI "Claw Sign" Improves Differentiation of Infectious from Degenerative Modic Type 1 Signal Changes of the Spine

(2014) K. B. Patel et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Fusion techniques for adult isthmic spondylolisthesis: a systematic review

(2014) Shan-Jin Wang et al.   ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY

Association between intervertebral disc degeneration and endplate perfusion studied by DCE-MRI

(2014) L. Tugan Muftuler et al.   EUROPEAN SPINE JOURNAL

Fusion in degenerative spondylolisthesis: comparison of osteoconductive and osteoinductive bone graft substitutes

(2014) Mark Kurd et al.   EUROPEAN SPINE JOURNAL

Effects of Spinal Stabilization Exercise on the Cross-sectional Areas of the Lumbar Multifidus and Psoas Major Muscles, Pain Intensity, and Lumbar Muscle Strength of Patients with Degenerative Disc Disease

(2014) Seongho Kim et al.   Journal of Physical Therapy Science

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

(2014) Louise E Clarke et al.   ARTHRITIS RESEARCH & THERAPY

Decision Making in Surgical Treatment of Chronic Low Back Pain: The performance of prognostic tests to select patients for lumbar spinal fusion

(2013) Paul Willems   Acta Orthopaedica

Th17 lymphocyte levels are higher in patients with ruptured than non-ruptured lumbar discs, and are correlated with pain intensity

(2013) Lei Cheng et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Bone marrow fat quantification in the presence of trabecular bone: Initial comparison between water-fat imaging and single-voxel MRS

(2013) Dimitrios C. Karampinos et al.   MAGNETIC RESONANCE IN MEDICINE

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Prospective, Multicenter, Randomized, Controlled Study of Anular Repair in Lumbar Discectomy

(2013) Alexander Bailey et al.   SPINE

The effects of microenvironment in mesenchymal stem cell–based regeneration of intervertebral disc

(2013) Yong-Can Huang et al.   Spine Journal

Results of pulsed radiofrequency technique with two laterally placed electrodes in the annulus in patients with chronic lumbar discogenic pain

(2012) Sei Fukui et al.   Journal of Anesthesia

Prospective study of disc repair with allogeneic chondrocytes Presented at the 2012 Joint Spine Section Meeting

(2012) Domagoj Coric et al.   JOURNAL OF NEUROSURGERY-SPINE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project

(2012) A.P. Goode et al.   OSTEOARTHRITIS AND CARTILAGE

Lumbar Diskogenic Pain, Provocation Diskography, and Imaging Correlates

(2012) Timothy P. Maus et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

Correlation between disability and MRI findings in lumbar spinal stenosis

(2011) Freyr G Sigmundsson et al.   Acta Orthopaedica

Is the presence of Modic changes associated with the outcomes of different treatments? A systematic critical review

(2011) Rikke K Jensen et al.   BMC MUSCULOSKELETAL DISORDERS

The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1

(2011) Anthony J. Hayes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Quantitative Measures of Modic Changes in Lumbar Spine Magnetic Resonance Imaging

(2011) Yue Wang et al.   SPINE

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors

(2011) Kwang-Il Lee et al.   SPINE

Standards of Practice: Quality Assurance Guidelines for Percutaneous Treatments of Intervertebral Discs

(2010) Alexis D. Kelekis et al.   CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY

Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial

(2010) Peter C. Gerszten et al.   JOURNAL OF NEUROSURGERY-SPINE

Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

(2010) Durval Campos Kraychete et al.   Sao Paulo Medical Journal

Minimal Access Versus Open Transforaminal Lumbar Interbody Fusion

(2010) Ray H. Wu et al.   SPINE

Graft Options in Posterolateral and Posterior Interbody Lumbar Fusion

(2010) Jeffrey A. Rihn et al.   SPINE

Percutaneous Treatment of Intervertebral Disc Herniation

(2010) Xavier Buy et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc

(2009) Karin Wuertz et al.   SPINE

Formulations of Polyvinyl Alcohol Cryogel That Mimic the Biomechanical Properties of Soft Tissues in the Natural Lumbar Intervertebral Disc

(2009) Bill Hao Wang et al.   SPINE

Nonsurgical Interventional Therapies for Low Back Pain

(2009) Roger Chou et al.   SPINE

Diffusion tensor imaging and tractography of the median nerve in carpal tunnel syndrome: preliminary results

(2008) C. Khalil et al.   EUROPEAN RADIOLOGY

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography

(2008) Takehiko Takagi et al.   NEUROIMAGE

The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells

(2007) Lars Gilbertson et al.   Spine Journal