IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity

IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity

(2019) Chongchao Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of SHIP2 participates in the development of breast cancer via promoting Wnt/β-catenin signaling

(2019) Juan Zhou et al.   OncoTargets and Therapy

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway

(2019) Haibin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

(2018) Zydrune Polianskyte-Prause et al.   FASEB JOURNAL

PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K

(2017) Mouhannad Malek et al.   MOLECULAR CELL

Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers

(2017) Dinesh Kumar et al.   PLoS One

Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases

(2016) M. J. Eramo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

(2015) Takashi Watanabe et al.   CELL STRUCTURE AND FUNCTION

Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling

(2015) ZHUO DENG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt

(2015) Yan Ye et al.   JOURNAL OF GASTROENTEROLOGY

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

(2015) Amr M. Ghaleb et al.   PLoS One

High SHIP2 Expression Indicates Poor Survival in Colorectal Cancer

(2014) Ju Yang et al.   DISEASE MARKERS

Significance of AKT in gastric cancer (Review)

(2014) TAKAMITSU SASAKI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

How does SHIP1/2 balance PtdIns(3,4)P2and does it signal independently of its phosphatase activity?

(2013) Jingwei Xie et al.   BIOESSAYS

Transcript Profiling Identifies Iqgap2−/− Mouse as a Model for Advanced Human Hepatocellular Carcinoma

(2013) Dmitri V. Gnatenko et al.   PLoS One

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

(2013) Yan Ye et al.   Nature Communications

IQGAP2, A candidate tumour suppressor of prostate tumorigenesis

(2012) Yanyun Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reversible Ser/Thr SHIP phosphorylation: A new paradigm in phosphoinositide signalling?

(2012) William's Elong Edimo et al.   BIOESSAYS

The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration

(2012) Katsuhiro Kato et al.   MOLECULAR BIOLOGY OF THE CELL

Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake

(2011) Carmine S. Chiariello et al.   REGULATORY PEPTIDES

An Emerging Role for IQGAP1 in Regulating Protein Traffic

(2011) Mahasin Osman   TheScientificWorldJOURNAL

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma

(2010) Colin D White et al.   BMC GASTROENTEROLOGY

IQGAP1 regulation and roles in cancer

(2009) Michael Johnson et al.   CELLULAR SIGNALLING

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

(2009) Colin D. White et al.   FEBS LETTERS

MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia

(2008) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA