IRTKS Promotes Insulin Signaling Transduction through Inhibiting SHIP2 Phosphatase Activity

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells

(2018) Somadri Ghosh et al.   JOURNAL OF CELL SCIENCE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

IRTKS is correlated with progression and survival time of patients with gastric cancer

(2017) Li-Yu Huang et al.   GUT

The SH3 domain distinguishes the role of I-BAR proteins IRTKS and MIM in chemotactic response to serum

(2016) Lushen Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells

(2015) Sattar Gorgani-Firuzjaee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt

(2015) Yan Ye et al.   JOURNAL OF GASTROENTEROLOGY

When Physics Takes Over: BAR Proteins and Membrane Curvature

(2015) Mijo Simunovic et al.   TRENDS IN CELL BIOLOGY

The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis

(2014) J. Linkner et al.   JOURNAL OF CELL SCIENCE

Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance

(2013) Li-Yu Huang et al.   CELL RESEARCH

Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons

(2013) Alain C. Burette et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

(2012) Stephen J. Mills et al.   ACS Chemical Biology

Decreased Hepatic Phosphatidylinositol-3,4,5-Triphosphate (PIP3) Levels and Impaired Glucose Homeostasis in Type 1 and Type 2 Diabetic Rats

(2012) Prasenjit Manna et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma

(2012) Na Cheng et al.   HEPATOLOGY

Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

(2011) Kunyan He et al.   MOLECULAR BIOLOGY OF THE CELL

Insulin Receptor Tyrosine Kinase Substrate Enhances Low Levels of MDM2-Mediated p53 Ubiquitination

(2011) Ke-Sheng Wang et al.   PLoS One

Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53

(2008) M HEUNG et al.   EUROPEAN JOURNAL OF CELL BIOLOGY